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Title: Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO)

Abstract

The toxicity of heavy metals such as lead (Pb), cadmium (Cd) and tin (Sn) has long been known but accidental exposures of large populations to these elements remain unfortunately a topical issue. Chelating agents against Pb, Cd, or Sn poisoning are still limited to classical ligands such as ethylenediamine tetraacetic acid (EDTA). In this paper, we evaluate the ability of 3,4,3-LI(1,2-HOPO) (L 4-), an octadentate ligand currently under evaluation for actinide decorporation, to bind Pb, Cd and Sn metal ions in aqueous solutions. This ligand forms 1 : 1 complexes with Pb(II), Cd(II) and Sn(IV) as well as bimetallic 2 : 1 species with Pb(II) and Cd(II), all of which were characterized by high resolution mass spectrometry and spectrophotometric titrations. The 3,4,3-LI(1,2-HOPO) ligand exhibits an extreme affinity for Sn(IV) ions (log β 110 > 40), with the complex remaining stable from highly acidic conditions to alkaline media (from 3 M HCl to pH 8). Single crystals of the neutral complex [Sn IV3,4,3-LI(1,2-HOPO)·3H 2O] were obtained and its structure determined, revealing a chiral conformation. Finally, although not initially designed for hexacoordinated metals such as Pb(II) and Cd(II), the octadentate ligand shows promise for the in vitro or in vivo sequestration ofmore » toxic heavy metals, as evidenced by decorporation experiments performed in mice contaminated with 210Pb(II) and treated with either EDTA or 3,4,3-LI(1,2-HOPO).« less

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [1]; ORCiD logo [3]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Chemical Sciences Division
  2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Chemical Sciences Division; Univ. of California, Berkeley, CA (United States). Dept. of Chemistry
  3. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Chemical Sciences Division; Univ. of California, Berkeley, CA (United States). Dept. of Nuclear Engineering
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1458507
Grant/Contract Number:
AC02-05CH11231
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
New Journal of Chemistry
Additional Journal Information:
Journal Volume: 42; Journal Issue: 10; Journal ID: ISSN 1144-0546
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Deblonde, Gauthier J. -P., Lohrey, Trevor D., An, Dahlia D., and Abergel, Rebecca J. Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO). United States: N. p., 2018. Web. doi:10.1039/c7nj04559j.
Deblonde, Gauthier J. -P., Lohrey, Trevor D., An, Dahlia D., & Abergel, Rebecca J. Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO). United States. doi:10.1039/c7nj04559j.
Deblonde, Gauthier J. -P., Lohrey, Trevor D., An, Dahlia D., and Abergel, Rebecca J. Fri . "Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO)". United States. doi:10.1039/c7nj04559j.
@article{osti_1458507,
title = {Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO)},
author = {Deblonde, Gauthier J. -P. and Lohrey, Trevor D. and An, Dahlia D. and Abergel, Rebecca J.},
abstractNote = {The toxicity of heavy metals such as lead (Pb), cadmium (Cd) and tin (Sn) has long been known but accidental exposures of large populations to these elements remain unfortunately a topical issue. Chelating agents against Pb, Cd, or Sn poisoning are still limited to classical ligands such as ethylenediamine tetraacetic acid (EDTA). In this paper, we evaluate the ability of 3,4,3-LI(1,2-HOPO) (L4-), an octadentate ligand currently under evaluation for actinide decorporation, to bind Pb, Cd and Sn metal ions in aqueous solutions. This ligand forms 1 : 1 complexes with Pb(II), Cd(II) and Sn(IV) as well as bimetallic 2 : 1 species with Pb(II) and Cd(II), all of which were characterized by high resolution mass spectrometry and spectrophotometric titrations. The 3,4,3-LI(1,2-HOPO) ligand exhibits an extreme affinity for Sn(IV) ions (log β110 > 40), with the complex remaining stable from highly acidic conditions to alkaline media (from 3 M HCl to pH 8). Single crystals of the neutral complex [SnIV3,4,3-LI(1,2-HOPO)·3H2O] were obtained and its structure determined, revealing a chiral conformation. Finally, although not initially designed for hexacoordinated metals such as Pb(II) and Cd(II), the octadentate ligand shows promise for the in vitro or in vivo sequestration of toxic heavy metals, as evidenced by decorporation experiments performed in mice contaminated with 210Pb(II) and treated with either EDTA or 3,4,3-LI(1,2-HOPO).},
doi = {10.1039/c7nj04559j},
journal = {New Journal of Chemistry},
number = 10,
volume = 42,
place = {United States},
year = {Fri Feb 02 00:00:00 EST 2018},
month = {Fri Feb 02 00:00:00 EST 2018}
}

Journal Article:
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