skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof

Abstract

The present invention is directed to devices, systems, and methods for detecting and/or monitoring one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest.

Inventors:
; ;
Publication Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1457027
Patent Number(s):
9,987,427
Application Number:
14/746,301
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM) SNL
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Jun 22
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Polsky, Ronen, Miller, Philip Rocco, and Edwards, Thayne L. Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof. United States: N. p., 2018. Web.
Polsky, Ronen, Miller, Philip Rocco, & Edwards, Thayne L. Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof. United States.
Polsky, Ronen, Miller, Philip Rocco, and Edwards, Thayne L. Tue . "Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof". United States. https://www.osti.gov/servlets/purl/1457027.
@article{osti_1457027,
title = {Diagnostic/drug delivery "sense-respond" devices, systems, and uses thereof},
author = {Polsky, Ronen and Miller, Philip Rocco and Edwards, Thayne L.},
abstractNote = {The present invention is directed to devices, systems, and methods for detecting and/or monitoring one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {6}
}

Patent:

Save / Share:

Works referenced in this record:

Nanoelectrodes, nanoelectrode arrays and their applications
journal, January 2004

  • Arrigan, Damien W. M.
  • The Analyst, Vol. 129, Issue 12, p. 1157-1165
  • DOI: 10.1039/b415395m

Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 1. General Characteristics
journal, December 1997

  • Bakker, Eric; B�hlmann, Philippe; Pretsch, Ern�
  • Chemical Reviews, Vol. 97, Issue 8, p. 3083-3132
  • DOI: 10.1021/cr940394a

Possibilities and limitations in miniaturized sensor design for uric acid
journal, January 1998

  • Bravo, Roberto; Hsueh, ChenChan; Brajter-Toth, Anna
  • The Analyst, Vol. 123, Issue 7, p. 1625-1630
  • DOI: 10.1039/a802341g

Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects
journal, January 2006

  • Brown, Marc B.; Martin, Gary P.; Jones, Stuart A.
  • Drug Delivery, Vol. 13, Issue 3, p. 175-187
  • DOI: 10.1080/10717540500455975

Lithographically Defined Porous Carbon Electrodes
journal, December 2009

  • Burckel, D. Bruce; Washburn, Cody M.; Raub, Alex K.
  • Small, Vol. 5, Issue 24, p. 2792-2796
  • DOI: 10.1002/smll.200901084

Mediated electrocatalytic oxidation of bioanalytes and biosensing of glutamate using functionalized multiwall carbon nanotubes-biopolymer nanocomposite
journal, November 2007


Insertion Force Estimation of Various Microneedle Array-type Structures Fabricated by a Microstereolithography Apparatus
conference, October 2006

  • Choi, Jae-won; Park, In-baek; Ha, Young-myoung
  • 2006 SICE-ICASE International Joint Conference
  • DOI: 10.1109/SICE.2006.315024

Effect of microneedles shape on skin penetration and minimally invasive continuous glucose monitoring in vivo
journal, December 2013

  • Chua, Beelee; Desai, Shashi P.; Tierney, Michael J.
  • Sensors and Actuators A: Physical, Vol. 203, p. 373-381
  • DOI: 10.1016/j.sna.2013.09.026

Early circulating biomarker detection using a wearable microprojection array skin patch
journal, December 2013


Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding
journal, January 2010

  • Corrie, Simon R.; Fernando, Germain J. P.; Crichton, Michael L.
  • Lab on a Chip, Vol. 10, Issue 20, p. 2655-2658
  • DOI: 10.1039/c0lc00068j

Ion-Selective Electrodes Using Carbon Nanotubes as Ion-to-Electron Transducers
journal, February 2008

  • Crespo, Gast�n A.; Macho, Santiago; Rius, F. Xavier
  • Analytical Chemistry, Vol. 80, Issue 4, p. 1316-1322
  • DOI: 10.1021/ac071156l

Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm
journal, January 2014

  • Dagdeviren, Canan; Yang, Byung Duk; Su, Yewang
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 5, p. 1927-1932
  • DOI: 10.1073/pnas.1317233111

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability
journal, November 2008

  • Davidson, Adam; Al-Qallaf, Barrak; Das, Diganta Bhusan
  • Chemical Engineering Research and Design, Vol. 86, Issue 11, p. 1196-1206
  • DOI: 10.1016/j.cherd.2008.06.002

Hollow Metal Microneedles for Insulin Delivery to Diabetic Rats
journal, May 2005

  • Davis, S. P.; Martanto, W.; Allen, M. G.
  • IEEE Transactions on Biomedical Engineering, Vol. 52, Issue 5, p. 909-915
  • DOI: 10.1109/TBME.2005.845240

Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force
journal, August 2004


Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique
journal, May 2010

  • Donnelly, Ryan F.; Majithiya, Rita; Singh, Thakur Raghu Raj
  • Pharmaceutical Research, Vol. 28, Issue 1, p. 41-57
  • DOI: 10.1007/s11095-010-0169-8

Covalent modification of carbon electrodes for voltammetric differentiation of dopamine and ascorbic acid
journal, December 1995

  • Downard, Alison J.; Roddick, Alisa D.; Bond, Alan M.
  • Analytica Chimica Acta, Vol. 317, Issue 1-3, p. 303-310
  • DOI: 10.1016/0003-2670(95)00397-5

Use of Microneedle Array Devices for Continuous Glucose Monitoring: A Review
journal, January 2013

  • El-Laboudi, Ahmed; Oliver, Nick S.; Cass, Anthony
  • Diabetes Technology & Therapeutics, Vol. 15, Issue 1, p. 101-115
  • DOI: 10.1089/dia.2012.0188

Preliminary technological assessment of microneedles-based dry electrodes for biopotential monitoring in clinical examinations
journal, June 2012

  • Forvi, Elena; Bedoni, Marzia; Carabalona, Roberta
  • Sensors and Actuators A: Physical, Vol. 180, p. 177-186
  • DOI: 10.1016/j.sna.2012.04.019

Dexcom G4AP: An Advanced Continuous Glucose Monitor for the Artificial Pancreas
journal, November 2013

  • Garcia, Arturo; Rack-Gomer, Anna Leigh; Bhavaraju, Naresh C.
  • Journal of Diabetes Science and Technology, Vol. 7, Issue 6, p. 1436-1445
  • DOI: 10.1177/193229681300700604

Silicon micromachined hollow microneedles for transdermal liquid transport
journal, December 2003

  • Gardeniers, H. J. G. E.; Luttge, R.; Berenschot, E. J. W.
  • Journal of Microelectromechanical Systems, Vol. 12, Issue 6, p. 855-862
  • DOI: 10.1109/JMEMS.2003.820293

Wearable and Portable eHealth Systems
journal, September 2007

  • Gatzoulis, Loukianos; Iakovidis, Ilias
  • IEEE Engineering in Medicine and Biology Magazine, Vol. 26, Issue 5, p. 51-56
  • DOI: 10.1109/EMB.2007.901787

Coated microneedles for transdermal delivery
journal, February 2007


Effect of Microneedle Design on Pain in Human Volunteers
journal, January 2008

  • Gill, Harvinder S.; Denson, Donald D.; Burris, Brett A.
  • The Clinical Journal of Pain, Vol. 24, Issue 7, p. 585-594
  • DOI: 10.1097/AJP.0b013e31816778f9

Fabrication of microscale medical devices by two-photon polymerization with multiple foci via a spatial light modulator
journal, January 2011

  • Gittard, Shaun D.; Nguyen, Alexander; Obata, Kotaro
  • Biomedical Optics Express, Vol. 2, Issue 11, p. 3167-3178
  • DOI: 10.1364/BOE.2.003167

Fabrication of Polymer Microneedles Using a Two-Photon Polymerization and Micromolding Process
journal, March 2009

  • Gittard, Shaun D.; Ovsianikov, Aleksandr; Monteiro-Riviere, Nancy A.
  • Journal of Diabetes Science and Technology, Vol. 3, Issue 2, p. 304-311
  • DOI: 10.1177/193229680900300211

Multiphoton microscopy of transdermal quantum dot delivery using two photonpolymerization-fabricated polymer microneedles
journal, January 2011

  • Gittard, Shaun D.; Miller, Philip R.; Boehm, Ryan D.
  • Faraday Discussions, Vol. 149, p. 171-185
  • DOI: 10.1039/C005374K

Two-photon polymerization of microneedles for transdermal drug delivery
journal, March 2010

  • Gittard, Shaun D.; Ovsianikov, Aleksandr; Chichkov, Boris N.
  • Expert Opinion on Drug Delivery, Vol. 7, Issue 4, p. 513-533
  • DOI: 10.1517/17425241003628171

Point of Care Diagnostics: Status and Future
journal, December 2011

  • Gubala, Vladimir; Harris, Leanne F.; Ricco, Antonio J.
  • Analytical Chemistry, Vol. 84, Issue 2, p. 487-515
  • DOI: 10.1021/ac2030199

A Multifunctional Thin Film Au Electrode Surface Formed by Consecutive Electrochemical Reduction of Aryl Diazonium Salts
journal, March 2009

  • Harper, Jason C.; Polsky, Ronen; Wheeler, David R.
  • Langmuir, Vol. 25, Issue 5, p. 3282-3288
  • DOI: 10.1021/la803215z

Maleimide-Activated Aryl Diazonium Salts for Electrode Surface Functionalization with Biological and Redox-Active Molecules
journal, March 2008

  • Harper, Jason C.; Polsky, Ronen; Wheeler, David R.
  • Langmuir, Vol. 24, Issue 5, p. 2206-2211
  • DOI: 10.1021/la702613e

Selective Immobilization of DNA and Antibody Probes on Electrode Arrays:� Simultaneous Electrochemical Detection of DNA and Protein on a Single Platform
journal, July 2007

  • Harper, Jason C.; Polsky, Ronen; Wheeler, David R.
  • Langmuir, Vol. 23, Issue 16, p. 8285-8287
  • DOI: 10.1021/la701775g

Some Recent Designs and Developments of Screen?Printed Carbon Electrochemical Sensors/Biosensors for Biomedical, Environmental, and Industrial Analyses
journal, January 2004

  • Hart, John P.; Crew, Adrian; Crouch, Eric
  • Analytical Letters, Vol. 37, Issue 5, p. 789-830
  • DOI: 10.1081/AL-120030682

Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity
journal, January 2003

  • Heien, Michael L. A. V.; Phillips, Paul E. M.; Stuber, Garret D.
  • The Analyst, Vol. 128, Issue 12, p. 1413-1419
  • DOI: 10.1039/b307024g

Microneedle Electrodes Toward an Amperometric Glucose-Sensing Smart Patch
journal, August 2013

  • Invernale, Michael A.; Tang, Benjamin C.; York, Royce L.
  • Advanced Healthcare Materials, Vol. 3, Issue 3, p. 338-342
  • DOI: 10.1002/adhm.201300142

Review: Carbon nanotube based electrochemical sensors for biomolecules
journal, March 2010

  • Jacobs, Christopher B.; Peairs, M. Jennifer; Venton, B. Jill
  • Analytica Chimica Acta, Vol. 662, Issue 2, p. 105-127
  • DOI: 10.1016/j.aca.2010.01.009

Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration
journal, July 2013

  • Jia, Wenzhao; Bandodkar, Amay J.; Vald�s-Ram�rez, Gabriela
  • Analytical Chemistry, Vol. 85, Issue 14, p. 6553-6560
  • DOI: 10.1021/ac401573r

Design, Development, and Evaluation of a Novel Microneedle Array-based Continuous Glucose Monitor
journal, March 2014

  • Jina, Arvind; Tierney, Michael J.; Tamada, Janet A.
  • Journal of Diabetes Science and Technology, Vol. 8, Issue 3, p. 483-487
  • DOI: 10.1177/1932296814526191

Review of analytical figures of merit of sensors and biosensors in clinical applications
journal, November 2010

  • Justino, Celine I. L.; Rocha-Santos, Teresa A.; Duarte, Armando C.
  • TrAC Trends in Analytical Chemistry, Vol. 29, Issue 10, p. 1172-1183
  • DOI: 10.1016/j.trac.2010.07.008

Lack of Pain Associated with Microfabricated Microneedles
journal, January 2001


Epidermal Electronics
journal, August 2011


A tapered hollow metallic microneedle array using backside exposure of SU-8
journal, February 2004

  • Kim, Kabseog; Park, Daniel S.; Lu, Hong M.
  • Journal of Micromechanics and Microengineering, Vol. 14, Issue 4, p. 597-603
  • DOI: 10.1088/0960-1317/14/4/021

Fabrication process for tall, sharp, hollow, high aspect ratio polymer microneedles on a platform
journal, June 2013

  • Ceyssens, Frederik; Chaudhri, Buddhadev Paul; Van Hoof, Chris
  • Journal of Micromechanics and Microengineering, Vol. 23, Issue 7, Article No. 075023
  • DOI: 10.1088/0960-1317/23/7/075023

A Novel Method for Monolithic Fabrication of Polymer Microneedles on a Platform for Transdermal Drug Delivery
conference, July 2013

  • Chaudhuri, Buddhadev P.; Ceyssens, F.; Van Hoof, C.
  • 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
  • DOI: 10.1109/EMBC.2013.6609461

Hydrogel-Forming Microneedles Increase in Volume During Swelling in Skin, but Skin Barrier Function Recovery is Unaffected
journal, May 2014

  • Donnelly, Ryan F.; Mooney, Karen; Mccrudden, Mael�osa T. C.
  • Journal of Pharmaceutical Sciences, Vol. 103, Issue 5, p. 1478-1486
  • DOI: 10.1002/jps.23921

A parallel microfluidic channel fixture fabricated using laser ablated plastic laminates for electrochemical and chemiluminescent biodetection of DNA
journal, December 2011

  • Edwards, Thayne L.; Harper, Jason C.; Polsky, Ronen
  • Biomicrofluidics, Vol. 5, Issue 4, Article No. 044115
  • DOI: 10.1063/1.3664694

Chitin Microneedles for an Easy-to-Use Tuberculosis Skin Test
journal, August 2013

  • Jin, Jungho; Reese, Valerie; Coler, Rhea
  • Advanced Healthcare Materials, Vol. 3, Issue 3, p. 349-353
  • DOI: 10.1002/adhm.201300185

Microneedle Biosensor for Real-Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy
journal, February 2015

  • Keum, Do Hee; Jung, Ho Sang; Wang, Taejun
  • Advanced Healthcare Materials, Vol. 4, Issue 8, p. 1153-1158
  • DOI: 10.1002/adhm.201500012

Microneedles for drug and vaccine delivery
journal, November 2012

  • Kim, Yeu-Chun; Park, Jung-Hwan; Prausnitz, Mark R.
  • Advanced Drug Delivery Reviews, Vol. 64, Issue 14, p. 1547-1568
  • DOI: 10.1016/j.addr.2012.04.005

Ion-Selective Electrodes with Three-Dimensionally Ordered Macroporous Carbon as the Solid Contact
journal, June 2007

  • Lai, Chun-Ze; Fierke, Melissa A.; Stein, Andreas
  • Analytical Chemistry, Vol. 79, Issue 12, p. 4621-4626
  • DOI: 10.1021/ac070132b

Capture of the Circulating Plasmodium falciparum Biomarker HRP2 in a Multiplexed Format, via a Wearable Skin Patch
journal, October 2014

  • Lee, Khai Tuck; Muller, David A.; Coffey, Jacob W.
  • Analytical Chemistry, Vol. 86, Issue 20, p. 10474-10483
  • DOI: 10.1021/ac5031682

An optimized hollow microneedle for minimally invasive blood extraction
journal, July 2012

  • Li, Cheng Guo; Lee, Chang Yeol; Lee, Kwang
  • Biomedical Microdevices, Vol. 15, Issue 1, p. 17-25
  • DOI: 10.1007/s10544-012-9683-2

All-solid-state potassium-selective electrode using graphene as the solid contact
journal, January 2012

  • Li, Fenghua; Ye, Junjin; Zhou, Min
  • The Analyst, Vol. 137, Issue 3, p. 618-623
  • DOI: 10.1039/C1AN15705A

Biocompatibility of an Electrochemical Sensor for Continuous Glucose Monitoring in Subcutaneous Tissue
journal, February 2005

  • Mang, A.; Pill, J.; Gretz, N.
  • Diabetes Technology & Therapeutics, Vol. 7, Issue 1, p. 163-173
  • DOI: 10.1089/dia.2005.7.163

Mechanism of fluid infusion during microneedle insertion and retraction
journal, May 2006

  • Martanto, Wijaya; Moore, Jason S.; Couse, Tracey
  • Journal of Controlled Release, Vol. 112, Issue 3, p. 357-361
  • DOI: 10.1016/j.jconrel.2006.02.017

Microinfusion Using Hollow Microneedles
journal, January 2006

  • Martanto, Wijaya; Moore, Jason S.; Kashlan, Osama
  • Pharmaceutical Research, Vol. 23, Issue 1, p. 104-113
  • DOI: 10.1007/s11095-005-8498-8

The MiniMed Continuous Glucose Monitoring System
journal, December 2000

  • Mastrototaro, John J.
  • Diabetes Technology & Therapeutics, Vol. 2, Issue supplement 1, p. 13-18
  • DOI: 10.1089/15209150050214078

Poly vinyl alcohol re-usable masters for microneedle replication
journal, April 2009

  • Matteucci, Marco; Fanetti, M.; Casella, M.
  • Microelectronic Engineering, Vol. 86, Issue 4-6, p. 752-756
  • DOI: 10.1016/j.mee.2009.01.068

Microfabricated Microneedles for Gene and Drug Delivery
journal, August 2000

  • McAllister, Devin V.; Allen, Mark G.; Prausnitz, Mark R.
  • Annual Review of Biomedical Engineering, Vol. 2, Issue 1, p. 289-313
  • DOI: 10.1146/annurev.bioeng.2.1.289

Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies
journal, November 2003

  • McAllister, D. V.; Wang, P. M.; Davis, S. P.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 24, p. 13755-13760
  • DOI: 10.1073/pnas.2331316100

Advanced Carbon Electrode Materials for Molecular Electrochemistry
journal, July 2008

  • McCreery, Richard L.
  • Chemical Reviews, Vol. 108, Issue 7, p. 2646-2687
  • DOI: 10.1021/cr068076m

Microneedle-Based Transdermal Sensor for On-Chip Potentiometric Determination of K+
journal, December 2013

  • Miller, Philip R.; Xiao, Xiaoyin; Brener, Igal
  • Advanced Healthcare Materials, Vol. 3, Issue 6, p. 876-881
  • DOI: 10.1002/adhm.201300541

Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis
journal, January 2012


Microneedle array for transdermal biological fluid extraction and in situ analysis
journal, September 2004

  • Mukerjee, E. V.; Collins, S. D.; Isseroff, R. R.
  • Sensors and Actuators A: Physical, Vol. 114, Issue 2-3, p. 267-275
  • DOI: 10.1016/j.sna.2003.11.008

Surface Modified Microprojection Arrays for the Selective Extraction of the Dengue Virus NS1 Protein As a Marker for Disease
journal, March 2012

  • Muller, David A.; Corrie, Simon R.; Coffey, Jacob
  • Analytical Chemistry, Vol. 84, Issue 7, p. 3262-3268
  • DOI: 10.1021/ac2034387

Medical prototyping using two photon polymerization
journal, December 2010


Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine
journal, May 2013


Hollow microneedles for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition
journal, October 2012

  • Norman, James J.; Choi, Seong-O; Tong, Nhien T.
  • Biomedical Microdevices, Vol. 15, Issue 2, p. 203-210
  • DOI: 10.1007/s10544-012-9717-9

Influence of Array Interspacing on the Force Required for Successful Microneedle Skin Penetration: Theoretical and Practical Approaches
journal, April 2013

  • Olatunji, Ololade; Das, Diganta B.; Garland, Martin J.
  • Journal of Pharmaceutical Sciences, Vol. 102, Issue 4, p. 1209-1221
  • DOI: 10.1002/jps.23439

Two Photon Polymerization of Polymer�Ceramic Hybrid Materials for Transdermal Drug Delivery
journal, January 2007


In-plane single-crystal-silicon microneedles for minimally invasive microfluid systems
journal, September 2004

  • Paik, Seung-Joon; Byun, Sangwon; Lim, Jung-Min
  • Sensors and Actuators A: Physical, Vol. 114, Issue 2-3, p. 276-284
  • DOI: 10.1016/j.sna.2003.12.029

Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery
journal, May 2005

  • Park, Jung-Hwan; Allen, Mark G.; Prausnitz, Mark R.
  • Journal of Controlled Release, Vol. 104, Issue 1, p. 51-66
  • DOI: 10.1016/j.jconrel.2005.02.002

Tapered Conical Polymer Microneedles Fabricated Using an Integrated Lens Technique for Transdermal Drug Delivery
journal, May 2007

  • Park, Jung-Hwan; Yoon, Yong-Kyu; Choi, Seong-O
  • IEEE Transactions on Biomedical Engineering, Vol. 54, Issue 5, p. 903-913
  • DOI: 10.1109/TBME.2006.889173

Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol
journal, January 2006

  • P�renn�s, F.; Marmiroli, B.; Matteucci, M.
  • Journal of Micromechanics and Microengineering, Vol. 16, Issue 3, p. 473-479
  • DOI: 10.1088/0960-1317/16/3/001

Development of an all-solid-state potassium ion-selective electrode using graphene as the solid-contact transducer
journal, December 2011


Diazonium-Functionalized Horseradish Peroxidase Immobilized via Addressable Electrodeposition:� Direct Electron Transfer and Electrochemical Detection
journal, January 2007

  • Polsky, Ronen; Harper, Jason C.; Dirk, Shawn M.
  • Langmuir, Vol. 23, Issue 2, p. 364-366
  • DOI: 10.1021/la062916a

Electrically Addressable Cell Immobilization Using Phenylboronic Acid Diazonium Salts
journal, March 2008

  • Polsky, Ronen; Harper, Jason?C.; Wheeler, David?R.
  • Angewandte Chemie International Edition, Vol. 47, Issue 14, p. 2631-2634
  • DOI: 10.1002/anie.200704597

Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications
journal, January 2008

  • Polsky, Ronen; Harper, Jason C.; Wheeler, David R.
  • Biosensors and Bioelectronics, Vol. 23, Issue 6, p. 757-764
  • DOI: 10.1016/j.bios.2007.08.013

Multifunctional Electrode Arrays: Towards a Universal Detection Platform
journal, March 2008

  • Polsky, Ronen; Harper, Jason C.; Wheeler, David R.
  • Electroanalysis, Vol. 20, Issue 6, p. 671-679
  • DOI: 10.1002/elan.200704129

Nucleic Acid-Functionalized Pt Nanoparticles:� Catalytic Labels for the Amplified Electrochemical Detection of Biomolecules
journal, April 2006

  • Polsky, Ronen; Gill, Ron; Kaganovsky, Lubov
  • Analytical Chemistry, Vol. 78, Issue 7, p. 2268-2271
  • DOI: 10.1021/ac0519864

Nanomaterials meet microfluidics
journal, January 2011

  • Pumera, Martin
  • Chemical Communications, Vol. 47, Issue 20, p. 5671-5680
  • DOI: 10.1039/c1cc11060h

Physiological and Psychological Fatigue in Extreme Conditions: Overtraining and Elite Athletes
journal, May 2010


Targeted, Needle-Free Vaccinations in Skin using Multilayered, Densely-Packed Dissolving Microprojection Arrays
journal, July 2010

  • Raphael, Anthony P.; Prow, Tarl W.; Crichton, Michael L.
  • Small, Vol. 6, Issue 16, p. 1785-1793
  • DOI: 10.1002/smll.201000326

Collection of Analytes from Microneedle Patches
journal, October 2014

  • Romanyuk, Andrey V.; Zvezdin, Vasiliy N.; Samant, Pradnya
  • Analytical Chemistry, Vol. 86, Issue 21, p. 10520-10523
  • DOI: 10.1021/ac503823p

Fabrication of a hollow needle structure by dicing, wet etching and metal deposition
journal, September 2006

  • Shikida, Mitsuhiro; Hasada, Takehiko; Sato, Kazuo
  • Journal of Micromechanics and Microengineering, Vol. 16, Issue 10, p. 2230-2239
  • DOI: 10.1088/0960-1317/16/10/041

Biological application of microelectrode arrays in drug discovery and basic research
journal, October 2003

  • Stett, Alfred; Egert, Ulrich; Guenther, Elke
  • Analytical and Bioanalytical Chemistry, Vol. 377, Issue 3, p. 486-495
  • DOI: 10.1007/s00216-003-2149-x

Arrays of hollow out-of-plane microneedles for drug delivery
journal, June 2005

  • Stoeber, B.; Liepmann, D.
  • Journal of Microelectromechanical Systems, Vol. 14, Issue 3, p. 472-479
  • DOI: 10.1109/JMEMS.2005.844843

Dissolving polymer microneedle patches for influenza vaccination
journal, July 2010

  • Sullivan, Sean P.; Koutsonanos, Dimitrios G.; del Pilar Martin, Maria
  • Nature Medicine, Vol. 16, Issue 8, p. 915-920
  • DOI: 10.1038/nm.2182

Fabrication, Characterization, and Application of Boron-Doped Diamond Microelectrodes for in Vivo Dopamine Detection
journal, November 2007

  • Suzuki, Akane; Ivandini, Tribidasari A.; Yoshimi, Kenji
  • Analytical Chemistry, Vol. 79, Issue 22, p. 8608-8615
  • DOI: 10.1021/ac071519h

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
journal, January 2012

  • Miller, Philip R.; Skoog, Shelby A.; Edwards, Thayne L.
  • Journal of Visualized Experiments, Vol. 64, Article No. e4067
  • DOI: 10.3791/4067

Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing
journal, March 2011

  • Miller, Philip R.; Gittard, Shaun D.; Edwards, Thayne L.
  • Biomicrofluidics, Vol. 5, Issue 1, Article No. 013415
  • DOI: 10.1063/1.3569945

Microneedles for transdermal drug delivery
journal, March 2004


A disposable �intelligent mosquito� with a reversible sampling mechanism using the volume-phase transition of a gel
journal, March 2002

  • Suzuki, Hiroaki; Tokuda, Tomohisa; Kobayashi, Kuniyuki
  • Sensors and Actuators B: Chemical, Vol. 83, Issue 1-3, p. 53-59
  • DOI: 10.1016/S0925-4005(01)01028-0

Development of Blood Extraction System for Health Monitoring System
journal, December 2005

  • Tsuchiya, Kazuyoshi; Nakanishi, Naoyuki; Uetsuji, Yasutomo
  • Biomedical Microdevices, Vol. 7, Issue 4, p. 347-353
  • DOI: 10.1007/s10544-005-6077-8

Emerging synergy between nanotechnology and implantable biosensors: A review
journal, March 2010

  • Vaddiraju, Santhisagar; Tomazos, Ioannis; Burgess, Diane J.
  • Biosensors and Bioelectronics, Vol. 25, Issue 7, p. 1553-1565
  • DOI: 10.1016/j.bios.2009.12.001

Microneedle-based self-powered glucose sensor
journal, October 2014

  • Vald�s-Ram�rez, Gabriela; Li, Ya-Chieh; Kim, Jayoung
  • Electrochemistry Communications, Vol. 47, p. 58-62
  • DOI: 10.1016/j.elecom.2014.07.014

Microscopic gel�liquid interfaces supported by hollow microneedle array for voltammetric drug detection
journal, October 2014

  • Vazquez, Patricia; Herzog, Gr�goire; O�Mahony, Conor
  • Sensors and Actuators B: Chemical, Vol. 201, p. 572-578
  • DOI: 10.1016/j.snb.2014.04.080

Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin
journal, February 2007

  • Verbaan, F. J.; Bal, S. M.; van den Berg, D. J.
  • Journal of Controlled Release, Vol. 117, Issue 2, p. 238-245
  • DOI: 10.1016/j.jconrel.2006.11.009

Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method
journal, May 2008


Screen-Printable Sol?Gel Enzyme-Containing Carbon Inks
journal, January 1996

  • Wang, Joseph; Pamidi, Prasad V. A.; Park, Deog Su
  • Analytical Chemistry, Vol. 68, Issue 15, p. 2705-2708
  • DOI: 10.1021/ac960159n

Amperometric biosensors for clinical and therapeutic drug monitoring: a review
journal, February 1999


Electrochemical biosensors: Towards point-of-care cancer diagnostics
journal, April 2006


Electrochemical Glucose Biosensors
journal, February 2008

  • Wang, Joseph
  • Chemical Reviews, Vol. 108, Issue 2, p. 814-825
  • DOI: 10.1021/cr068123a

Hypodermic-needle-like hollow polymer microneedle array using UV lithography into micromolds
conference, January 2011

  • Wang, Po-Chun; Paik, Seung-Joon; Kim, Jooncheol
  • 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems
  • DOI: 10.1109/MEMSYS.2011.5734606

Minimally Invasive Extraction of Dermal Interstitial Fluid for Glucose Monitoring Using Microneedles
journal, February 2005

  • Wang, Ping M.; Cornwell, Megan; Prausnitz, Mark R.
  • Diabetes Technology & Therapeutics, Vol. 7, Issue 1, p. 131-141
  • DOI: 10.1089/dia.2005.7.131

Precise Microinjection into Skin Using Hollow Microneedles
journal, May 2006

  • Wang, Ping M.; Cornwell, Megan; Hill, James
  • Journal of Investigative Dermatology, Vol. 126, Issue 5, p. 1080-1087
  • DOI: 10.1038/sj.jid.5700150

Physiological and Psychological Fatigue in Extreme Conditions: The Military Example
journal, May 2010


Biosensors for real-time in vivo measurements
journal, June 2005

  • Wilson, George S.; Gifford, Raeann
  • Biosensors and Bioelectronics, Vol. 20, Issue 12, p. 2388-2403
  • DOI: 10.1016/j.bios.2004.12.003

Bicomponent Microneedle Array Biosensor for Minimally-Invasive Glutamate Monitoring
journal, September 2011

  • Windmiller, Joshua Ray; Vald�s-Ram�rez, Gabriela; Zhou, Nandi
  • Electroanalysis, Vol. 23, Issue 10, p. 2302-2309
  • DOI: 10.1002/elan.201100361

Wearable Electrochemical Sensors and Biosensors: A Review
journal, September 2012

  • Windmiller, Joshua Ray; Wang, Joseph
  • Electroanalysis, Vol. 25, Issue 1, p. 29-46
  • DOI: 10.1002/elan.201200349

Lithographically Defined Three-Dimensional Graphene Structures
journal, March 2012

  • Xiao, Xiaoyin; Beechem, Thomas E.; Brumbach, Michael T.
  • ACS Nano, Vol. 6, Issue 4, p. 3573-3579
  • DOI: 10.1021/nn300655c

A Bubble-Mediated Intelligent Microscale Electrochemical Device for Single-Step Quantitative Bioassays
journal, April 2014

  • Yang, Fan; Zuo, Xiaolei; Li, Zhenhua
  • Advanced Materials, Vol. 26, Issue 27, p. 4671-4676
  • DOI: 10.1002/adma.201400451

Surface Modification and Characterization of Polycarbonate Microdevices for Capture of Circulating Biomarkers, Both in Vitro and in Vivo
journal, October 2013

  • Yeow, Bernard; Coffey, Jacob W.; Muller, David A.
  • Analytical Chemistry, Vol. 85, Issue 21, p. 10196-10204
  • DOI: 10.1021/ac402942x

A microfabricated electrode with hollow microneedles for ECG measurement
journal, April 2009

  • Yu, L. M.; Tay, F. E. H.; Guo, D. G.
  • Sensors and Actuators A: Physical, Vol. 151, Issue 1, p. 17-22
  • DOI: 10.1016/j.sna.2009.01.020

Microdialysis Microneedles for Continuous Medical Monitoring
journal, March 2005

  • Zahn, Jeffrey D.; Trebotich, David; Liepmann, Dorian
  • Biomedical Microdevices, Vol. 7, Issue 1, p. 59-69
  • DOI: 10.1007/s10544-005-6173-9

Integrated Microcapillary for Sample-to-Answer Nucleic Acid Pretreatment, Amplification, and Detection
journal, October 2014

  • Zhang, Lu; Zhang, Yi; Wang, Chunyan
  • Analytical Chemistry, Vol. 86, Issue 20, p. 10461-10466
  • DOI: 10.1021/ac503072a

A microneedle-based glucose monitor: fabricated on a wafer-level using in-device enzyme immobilization
conference, January 2003

  • Zimmermann, S.; Fienbork, D.; Stoeber, B.
  • TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems
  • DOI: 10.1109/SENSOR.2003.1215262

Hollow polymer microneedle array fabricated by photolithography process combined with micromolding technique
conference, September 2009

  • Wang, Po-Chun; Wester, B. A.; Rajaraman, S.
  • 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • DOI: 10.1109/IEMBS.2009.5333317

A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue
journal, April 2013

  • Yang, Seung Yun; O'Cearbhaill, Eoin D.; Sisk, Geoffroy C.
  • Nature Communications, Vol. 4, Article No. 1702
  • DOI: 10.1038/ncomms2715

Sharp tipped plastic hollow microneedle array by microinjection moulding
journal, December 2011

  • Yung, K. L.; Xu, Yan; Kang, Chunlei
  • Journal of Micromechanics and Microengineering, Vol. 22, Issue 1, Article No. 015016
  • DOI: 10.1088/0960-1317/22/1/015016