Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network

Widhalm, Joshua R.; Gutensohn, Michael; Yoo, Heejin; Adebesin, Funmilayo; Qian, Yichun; Guo, Longyun; Jaini, Rohit; Lynch, Joseph H.; McCoy, Rachel M.; Shreve, Jacob T.; Thimmapuram, Jyothi; Rhodes, David; Morgan, John A.; Dudareva, Natalia

doi:10.1038/ncomms9142

Title: Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network

Journal Article · Thu Sep 10 00:00:00 EDT 2015 · Nature Communications

DOI:https://doi.org/10.1038/ncomms9142· OSTI ID:1455141

Widhalm, Joshua R. ^[1]; Gutensohn, Michael ^[2]; Yoo, Heejin ^[3]; Adebesin, Funmilayo ^[1]; Qian, Yichun ^[3]; Guo, Longyun ^[1]; Jaini, Rohit ^[4]; Lynch, Joseph H. ^[1]; McCoy, Rachel M. ^[1]; Shreve, Jacob T. ^[5]; Thimmapuram, Jyothi ^[5]; Rhodes, David ^[2]; Morgan, John A. ^[6]; Dudareva, Natalia ^[3]

Purdue Univ., West Lafayette, IN (United States). Dept. of Biochemistry
Purdue Univ., West Lafayette, IN (United States). Dept. of Horticulture and Landscape Architecture
Purdue Univ., West Lafayette, IN (United States). Dept. of Biochemistry. Dept. of Horticulture and Landscape Architecture
Purdue Univ., West Lafayette, IN (United States). School of Chemical Engineering
Purdue Univ., West Lafayette, IN (United States). Bioinformatics Core
Purdue Univ., West Lafayette, IN (United States). Dept. of Biochemistry. School of Chemical Engineering

In addition to proteins, L-phenylalanine is a versatile precursor for thousands of plant metabolites. Production of phenylalanine-derived compounds is a complex multi-compartmental process using phenylalanine synthesized predominantly in plastids as precursor. The transporter(s) exporting phenylalanine from plastids, however, remains unknown. Here, a gene encoding a Petunia hybrida plastidial cationic amino-acid transporter (PhpCAT) functioning in plastidial phenylalanine export is identified based on homology to an Escherichia coli phenylalanine transporter and co-expression with phenylalanine metabolic genes. Radiolabel transport assays show that PhpCAT exports all three aromatic amino acids. PhpCAT downregulation and overexpression result in decreased and increased levels, respectively, of phenylalanine-derived volatiles, as well as phenylalanine, tyrosine and their biosynthetic intermediates. Metabolic flux analysis reveals that flux through the plastidial phenylalanine biosynthetic pathway is reduced in PhpCAT RNAi lines, suggesting that the rate of phenylalanine export from plastids contributes to regulating flux through the aromatic amino-acid network.

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Research Organization:: Purdue Univ., West Lafayette, IN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); Gordon and Betty Moore Foundation (United States)

Grant/Contract Number:: SC0008628; GBMF2550.02

OSTI ID:: 1455141

Journal Information:: Nature Communications, Vol. 6; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 62 works

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