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Title: Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway

Abstract

The stability of DOTA-chelated complexes coordinated with H 2 O has a strong correlation between the opening angle of DOTA and the atomic mass of the radioactive isotope.

Authors:
 [1];  [2]; ORCiD logo [3];  [4]; ORCiD logo [5]; ORCiD logo [1]
  1. Department of Physics, University of South Florida, Tampa, USA
  2. Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
  3. Small Animal Imaging Laboratory Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
  4. Department of Pharmaceutical Sciences, West Virginia University, Health Sciences Center, Morgantown, USA
  5. Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA, Department of Oncologic Sciences
Publication Date:
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1454630
Grant/Contract Number:  
DE FG02-06ER46297
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
MedChemComm
Additional Journal Information:
Journal Name: MedChemComm Journal Volume: 9 Journal Issue: 7; Journal ID: ISSN 2040-2503
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Khabibullin, Artem R., Karolak, Aleksandra, Budzevich, Mikalai M., McLaughlin, Mark L., Morse, David L., and Woods, Lilia M.. Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway. United Kingdom: N. p., 2018. Web. doi:10.1039/C8MD00170G.
Khabibullin, Artem R., Karolak, Aleksandra, Budzevich, Mikalai M., McLaughlin, Mark L., Morse, David L., & Woods, Lilia M.. Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway. United Kingdom. doi:10.1039/C8MD00170G.
Khabibullin, Artem R., Karolak, Aleksandra, Budzevich, Mikalai M., McLaughlin, Mark L., Morse, David L., and Woods, Lilia M.. Mon . "Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway". United Kingdom. doi:10.1039/C8MD00170G.
@article{osti_1454630,
title = {Structure and properties of DOTA-chelated radiopharmaceuticals within the 225 Ac decay pathway},
author = {Khabibullin, Artem R. and Karolak, Aleksandra and Budzevich, Mikalai M. and McLaughlin, Mark L. and Morse, David L. and Woods, Lilia M.},
abstractNote = {The stability of DOTA-chelated complexes coordinated with H 2 O has a strong correlation between the opening angle of DOTA and the atomic mass of the radioactive isotope.},
doi = {10.1039/C8MD00170G},
journal = {MedChemComm},
number = 7,
volume = 9,
place = {United Kingdom},
year = {Mon Jan 01 00:00:00 EST 2018},
month = {Mon Jan 01 00:00:00 EST 2018}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on June 6, 2019
Publisher's Accepted Manuscript

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Works referenced in this record:

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Preclinical Evaluation of the α-Particle Generator Nuclide 225Ac for Somatostatin Receptor Radiotherapy of Neuroendocrine Tumors
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Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set
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Self-Consistent Equations Including Exchange and Correlation Effects
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