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Title: Targeted self-assembly of functionalized carbon nanotubes on tumors

Abstract

Provided herein are methods for delivering a molecule in situ to a cell and for treating a cancer via the in situ delivery. The methods comprise contacting or administering to the cell, as two separate components, a morpholino oligonucleotide comprising a targeting moiety followed by a single wall nanotube construct comprising second morpholino oligonucleotides complementary to the first morpholino oligonucleotides and one or both of a therapeutic or diagnostic payload molecule linked to the single wall nanotube construct. Upon self-assembly of a single wall nanotube complex via hybridization of the first morpholino and second complementary morpholino oligonucleotides at the cell, the payload molecule is delivered. Also provided is the two component self-assembly single wall nanotube system and the single wall nanotube construct comprising the second component.

Inventors:
; ; ;
Publication Date:
Research Org.:
Memorial Sloan Kettering Cancer Center, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1452898
Patent Number(s):
9,976,137
Application Number:
14/318,112
Assignee:
Scheinberg, David A. CHO
DOE Contract Number:  
SC0002456
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Jun 27
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Scheinberg, David A., McDevitt, Michael R., Villa, Carlos H., and Mulvey, J. Justin. Targeted self-assembly of functionalized carbon nanotubes on tumors. United States: N. p., 2018. Web.
Scheinberg, David A., McDevitt, Michael R., Villa, Carlos H., & Mulvey, J. Justin. Targeted self-assembly of functionalized carbon nanotubes on tumors. United States.
Scheinberg, David A., McDevitt, Michael R., Villa, Carlos H., and Mulvey, J. Justin. Tue . "Targeted self-assembly of functionalized carbon nanotubes on tumors". United States. doi:. https://www.osti.gov/servlets/purl/1452898.
@article{osti_1452898,
title = {Targeted self-assembly of functionalized carbon nanotubes on tumors},
author = {Scheinberg, David A. and McDevitt, Michael R. and Villa, Carlos H. and Mulvey, J. Justin},
abstractNote = {Provided herein are methods for delivering a molecule in situ to a cell and for treating a cancer via the in situ delivery. The methods comprise contacting or administering to the cell, as two separate components, a morpholino oligonucleotide comprising a targeting moiety followed by a single wall nanotube construct comprising second morpholino oligonucleotides complementary to the first morpholino oligonucleotides and one or both of a therapeutic or diagnostic payload molecule linked to the single wall nanotube construct. Upon self-assembly of a single wall nanotube complex via hybridization of the first morpholino and second complementary morpholino oligonucleotides at the cell, the payload molecule is delivered. Also provided is the two component self-assembly single wall nanotube system and the single wall nanotube construct comprising the second component.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 22 00:00:00 EDT 2018},
month = {Tue May 22 00:00:00 EDT 2018}
}

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