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Title: SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus

Journal Article · · Physica Status Solidi B. Basic Solid State Physics
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  1. Univ. of Liverpool, Liverpool (United Kingdom)
  2. Univ. of Liverpool, Liverpool (United Kingdom); Cockcroft Institute Sci-Tech Daresbury, Warrington (United Kingdom); Accelerator Science and Technology Centre (ASTeC) STFC Daresbury Lab. Sci-Tech Daresbury, Warrington (United Kingdom)
  3. Univ. of Liverpool, Liverpool (United Kingdom); Cockcroft Institute Sci-Tech Daresbury, Warrington (United Kingdom)
  4. Istituto di Struttura della Materia, Rome (Italy)
  5. Cockcroft Institute Sci-Tech Daresbury, Warrington (United Kingdom); Accelerator Science and Technology Centre (ASTeC) STFC Daresbury Lab. Sci-Tech Daresbury, Warrington (United Kingdom)
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The development of more accurate and sensitive diagnostic techniques is a key factor in efforts to improve cancer survival rates. The technique of infrared aperture fibre scanning near-field optical microscopy (IR-SNOM),together with radiation from the infrared free-electron laser (IR-FEL) on ALICEat Daresbury Laboratory (UK), has been used to obtain IR images of a crypt-like feature and the surrounding tissue; the tissue was taken from a patient with oesophageal adenocarcinoma and with a history of Barrett’s oesophagus. We have shown that the DNA signal is enhanced relative to other contributions in the region of the crypt, and the glycoprotein signal shows a less pronounced increase in the region of the crypt. The Amide II signal is found to be anti-correlated with the DNA and glycoprotein profiles. The absorbance of the Amide II signal is found to differ for three different types of cancer tissue. In conclusion, high-resolution IR images of the crypt reveal additional structure that would not be resolved in diffraction-limited techniques.

Research Organization:
Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC), High Energy Physics (HEP)
Grant/Contract Number:
AC02-07CH11359
OSTI ID:
1452785
Report Number(s):
FERMILAB-PUB-18-242; 1677477; TRN: US1900980
Journal Information:
Physica Status Solidi B. Basic Solid State Physics, Vol. 255, Issue 4; ISSN 0370-1972
Publisher:
Wiley-BlackwellCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 4 works
Citation information provided by
Web of Science

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Cited By (3)

Modern Scattering‐Type Scanning Near‐Field Optical Microscopy for Advanced Material Research journal April 2019
Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell journal January 2018
Submicron infrared imaging of an oesophageal cancer cell with chemical specificity using an IR-FEL journal November 2018

Figures / Tables (5)

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60 APPLIED LIFE SCIENCES
adenocarcinoma
DNA
infrared radiation
scanning near-field optical microscopy
tissue