skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mycotoxins: A Fungal Genomics Perspective

Abstract

The chemical and enzymatic diversity in the fungal kingdom is staggering. Large-scale fungal genome sequencing projects are generating a massive catalog of secondary metabolite biosynthetic genes and pathways. Fungal natural products are a boon and bane to man as valuable pharmaceuticals and harmful toxins. Understanding how these chemicals are synthesized will aid the development of new strategies to limit mycotoxin contamination of food and feeds as well as expand drug discovery programs. A survey of work focused on the fumonisin family of mycotoxins highlights technological advances and provides a blueprint for future studies of other fungal natural products. Expressed sequence tags led to the discovery of new fumonisin genes (FUM) and hinted at a role for alternatively spliced transcripts in regulation. Phylogenetic studies of FUM genes uncovered a complex evolutionary history of the FUM cluster, as well as fungi with the potential to synthesize fumonisin or fumonisin-like chemicals. The application of new technologies (e.g., CRISPR) could substantially impact future efforts to harness fungal resources.

Authors:
;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1440641
Report Number(s):
PNNL-SA-129681
KP1704020
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Book
Resource Relation:
Related Information: Mycotoxigenic Fungi. Methods in Molecular Biology, 1542:367-379
Country of Publication:
United States
Language:
English

Citation Formats

Brown, Daren W., and Baker, Scott E. Mycotoxins: A Fungal Genomics Perspective. United States: N. p., 2017. Web. doi:10.1007/978-1-4939-6707-0_24.
Brown, Daren W., & Baker, Scott E. Mycotoxins: A Fungal Genomics Perspective. United States. doi:10.1007/978-1-4939-6707-0_24.
Brown, Daren W., and Baker, Scott E. Mon . "Mycotoxins: A Fungal Genomics Perspective". United States. doi:10.1007/978-1-4939-6707-0_24.
@article{osti_1440641,
title = {Mycotoxins: A Fungal Genomics Perspective},
author = {Brown, Daren W. and Baker, Scott E.},
abstractNote = {The chemical and enzymatic diversity in the fungal kingdom is staggering. Large-scale fungal genome sequencing projects are generating a massive catalog of secondary metabolite biosynthetic genes and pathways. Fungal natural products are a boon and bane to man as valuable pharmaceuticals and harmful toxins. Understanding how these chemicals are synthesized will aid the development of new strategies to limit mycotoxin contamination of food and feeds as well as expand drug discovery programs. A survey of work focused on the fumonisin family of mycotoxins highlights technological advances and provides a blueprint for future studies of other fungal natural products. Expressed sequence tags led to the discovery of new fumonisin genes (FUM) and hinted at a role for alternatively spliced transcripts in regulation. Phylogenetic studies of FUM genes uncovered a complex evolutionary history of the FUM cluster, as well as fungi with the potential to synthesize fumonisin or fumonisin-like chemicals. The application of new technologies (e.g., CRISPR) could substantially impact future efforts to harness fungal resources.},
doi = {10.1007/978-1-4939-6707-0_24},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {1}
}

Book:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this book.

Save / Share: