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Title: Metabolic Network Modeling for Computer-Aided Design of Microbial Interactions

Abstract

Interest in applying microbial communities to biotechnology continues to increase. Successful engineering of microbial communities requires a fundamental shift in focus from enhancing metabolic capabilities in individual organisms to promoting synergistic interspecies interactions. This goal necessitates in silico tools that provide a predictive understanding of how microorganisms interact with each other and their environments. In this regard, we highlight a need for a new concept that we have termed biological computer-aided design of interactions (BioCADi). We ground this discussion within the context of metabolic network modeling.

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1440621
Report Number(s):
PNNL-SA-115176
KP1601010
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Book
Resource Relation:
Related Information: Emerging Areas in Bioengineering, Part 7:793-801
Country of Publication:
United States
Language:
English
Subject:
Microbial communities; Biological Computer-Aided Design of Interactions (BioCADi); genome-scale metabolic network modeling; scoring metabolic interactions; flux balance analysis; elementary mode analysis; dynamic metabolic modeling

Citation Formats

Song, Hyun-Seob, Nelson, William C., Lee, Joon-Yong, Taylor, Ronald C., Henry, Christopher S., Beliaev, Alex S., Ramkrishna, Doraiswami, and Bernstein, Hans C. Metabolic Network Modeling for Computer-Aided Design of Microbial Interactions. United States: N. p., 2018. Web. doi:10.1002/9783527803293.
Song, Hyun-Seob, Nelson, William C., Lee, Joon-Yong, Taylor, Ronald C., Henry, Christopher S., Beliaev, Alex S., Ramkrishna, Doraiswami, & Bernstein, Hans C. Metabolic Network Modeling for Computer-Aided Design of Microbial Interactions. United States. doi:10.1002/9783527803293.
Song, Hyun-Seob, Nelson, William C., Lee, Joon-Yong, Taylor, Ronald C., Henry, Christopher S., Beliaev, Alex S., Ramkrishna, Doraiswami, and Bernstein, Hans C. Fri . "Metabolic Network Modeling for Computer-Aided Design of Microbial Interactions". United States. doi:10.1002/9783527803293.
@article{osti_1440621,
title = {Metabolic Network Modeling for Computer-Aided Design of Microbial Interactions},
author = {Song, Hyun-Seob and Nelson, William C. and Lee, Joon-Yong and Taylor, Ronald C. and Henry, Christopher S. and Beliaev, Alex S. and Ramkrishna, Doraiswami and Bernstein, Hans C.},
abstractNote = {Interest in applying microbial communities to biotechnology continues to increase. Successful engineering of microbial communities requires a fundamental shift in focus from enhancing metabolic capabilities in individual organisms to promoting synergistic interspecies interactions. This goal necessitates in silico tools that provide a predictive understanding of how microorganisms interact with each other and their environments. In this regard, we highlight a need for a new concept that we have termed biological computer-aided design of interactions (BioCADi). We ground this discussion within the context of metabolic network modeling.},
doi = {10.1002/9783527803293},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {1}
}

Book:
Other availability
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