DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication

Paulsen, Kevin S.; Deng, Yanxiang; Chung, Aram J.

doi:10.1002/advs.201800252

Title: DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication

Journal Article · Fri Jun 01 00:00:00 EDT 2018 · Advanced Science

DOI:https://doi.org/10.1002/advs.201800252· OSTI ID:1440257

^[1]; Deng, Yanxiang ^[2];

^[3]

Department of Mechanical, Aerospace, and Nuclear Engineering Rensselaer Polytechnic Institute (RPI) Troy NY 12180 USA, Engineering Directorate Lawrence Livermore National Laboratory (LLNL) Livermore CA 94550 USA
Department of Mechanical, Aerospace, and Nuclear Engineering Rensselaer Polytechnic Institute (RPI) Troy NY 12180 USA
Department of Mechanical, Aerospace, and Nuclear Engineering Rensselaer Polytechnic Institute (RPI) Troy NY 12180 USA, School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea

Abstract Complex‐shaped microparticles can enhance applications in drug delivery, tissue engineering, and structural materials, although techniques to fabricate these particles remain limited. A microfluidics‐based process called optofluidic fabrication that utilizes inertial flows and ultraviolet polymerization has shown great potential for creating highly 3D‐shaped particles in a high‐throughput manner, but the particle dimensions are mainly at the millimeter scale. Here, a next generation optofluidic fabrication process is presented that utilizes on‐the‐fly fabricated multiscale fluidic channels producing customized sub‐100 µm 3D‐shaped microparticles. This flexible design scheme offers a user‐friendly platform for rapid prototyping of new 3D particle shapes, providing greater potential for creating impactful engineered microparticles.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); Rensselaer Polytechnic Inst., Troy, NY (United States); Korea Univ., Seoul (Korea, Republic of)

Sponsoring Organization:: USDOE; National Science Foundation (NSF); Rensselaer Polytechnic Inst. (United States); Korea Univ. (Korea, Republic of)

Grant/Contract Number:: DE‐AC52‐07NA27344; AC52-07NA27344; IIA-1444104

OSTI ID:: 1440257

Alternate ID(s):: OSTI ID: 1440258; OSTI ID: 1465317

Report Number(s):: LLNL-JRNL-749963; 1800252

Journal Information:: Advanced Science, Journal Name: Advanced Science Vol. 5 Journal Issue: 7; ISSN 2198-3844

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

Citation Metrics:

Cited by: 16 works

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