Elucidation of Hydrogen Bonding Patterns in Ligand-Free, Lactose- and Glycerol-Bound Galectin-3C by Neutron Crystallography to Guide Drug Design

Manzoni, Francesco; Wallerstein, Johan; Schrader, Tobias E.; Ostermann, Andreas; Coates, Leighton; Akke, Mikael; Blakeley, Matthew P.; Oksanen, Esko; Logan, Derek T.

doi:10.1021/acs.jmedchem.8b00081

Title: Elucidation of Hydrogen Bonding Patterns in Ligand-Free, Lactose- and Glycerol-Bound Galectin-3C by Neutron Crystallography to Guide Drug Design

Journal Article · Thu Apr 19 00:00:00 EDT 2018 · Journal of Medicinal Chemistry

DOI:https://doi.org/10.1021/acs.jmedchem.8b00081· OSTI ID:1438966

Manzoni, Francesco ^[1]; Wallerstein, Johan ^[2];

^[3]; Ostermann, Andreas ^[4];

^[5];

^[2]; Blakeley, Matthew P. ^[6]; Oksanen, Esko ^[7];

^[1]

Department of Biochemistry & Structural Biology, Lund University, S-221 00 Lund, Sweden
Department of Biophysical Chemistry, Lund University, S-221 00 Lund, Sweden
Jülich Centre for Neutron Science (JCNS) at Heinz Maier-Leibnitz Zentrum (MLZ), Forschungszentrum Jülich GmbH, Lichtenbergstrasse 1, 85747 Garching, Germany
Heinz Maier-Leibnitz Zentrum (MLZ), Technische Universität München, Lichtenbergstrasse 1, 85748 Garching, Germany
Neutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831, United States
Institut Laue-Langevin, 71 avenue des Martyrs, 38000 Grenoble, France
Department of Biochemistry & Structural Biology, Lund University, S-221 00 Lund, Sweden, Instrument Division, European Spallation Source ERIC, Box 176, S-221 00 Lund, Sweden

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Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI ID:: 1438966

Journal Information:: Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Vol. 61 Journal Issue: 10; ISSN 0022-2623

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 25 works

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References (33)

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