DNA-cell conjugates

Hsiao, Shih-Chia; Francis, Matthew B.; Bertozzi, Carolyn; Mathies, Richard; Chandra, Ravi; Douglas, Erik; Twite, Amy; Toriello, Nicholas; Onoe, Hiroaki

Title: DNA-cell conjugates

Patent · Tue May 15 00:00:00 EDT 2018

OSTI ID:1438396

Hsiao, Shih-Chia; Francis, Matthew B.; Bertozzi, Carolyn; Mathies, Richard; Chandra, Ravi; Douglas, Erik; Twite, Amy; Toriello, Nicholas; Onoe, Hiroaki

The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland, CA)

Patent Number(s):: 9,969,970

Application Number:: 15/057,604

OSTI ID:: 1438396

Resource Relation:: Patent File Date: 2016 Mar 01

Country of Publication:: United States

Language:: English

References (15)

Cell targeting methods and compositions Caplan, ArnoldI https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060263336 US Patent Application 10/550590; 20060263336	patent-application	November 2006
Methods and systems for detecting and/or sorting targets Kwong, Gabriel A.; Bailey, Ryan C.; Fan, Rong https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090017455 US Patent Application 11/888502; 20090017455	patent-application	January 2009
Device and substance for the immobilization of mesenchymal stem cells (mscs) Wendel, Hans-Peter; Guo, Ketai; Schaefer, Richard https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090186356 US Patent Application 12/324698; 20090186356	patent-application	July 2009
Direct Cell Surface Modification with DNA for the Capture of Primary Cells and the Investigation of Myotube Formation on Defined Patterns Hsiao, Sonny C.; Shum, Betty J.; Onoe, Hiroaki Langmuir, Vol. 25, Issue 12, p. 6985-6991 https://doi.org/10.1021/la900150n	journal	June 2009
Recognition Imaging with a DNA Aptamer Lin, Liyun; Wang, Hongda; Liu, Yan Biophysical Journal, Vol. 90, Issue 11, p. 4236-4238 https://doi.org/10.1529/biophysj.105.079111	journal	June 2006
Behavior of synthetic polymers immobilized on a cell membrane Teramura, Yuji; Kaneda, Yoshihiro; Totani, Takahiko Biomaterials, Vol. 29, Issue 10, p. 1345-1355 https://doi.org/10.1016/j.biomaterials.2007.11.048	journal	April 2008
Integrated microfluidic bioprocessor for single-cell gene expression analysis Toriello, N. M.; Douglas, E. S.; Thaitrong, N. Proceedings of the National Academy of Sciences, Vol. 105, Issue 51, p. 20173-20178 https://doi.org/10.1073/pnas.0806355106	journal	December 2008
DNA-Coated AFM Cantilevers for the Investigation of Cell Adhesion and the Patterning of Live Cells Hsiao, Sonny C.; Crow, Ailey K.; Lam, Wilbur A. Angewandte Chemie International Edition, Vol. 47, Issue 44, p. 8473-8477 https://doi.org/10.1002/anie.200802525	journal	October 2008
Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles Tong, Gary J.; Hsiao, Sonny C.; Carrico, Zachary M. Journal of the American Chemical Society, Vol. 131, Issue 31, p. 11174-11178 https://doi.org/10.1021/ja903857f	journal	August 2009
A Universal Method for the Preparation of Covalent Protein–DNA Conjugates for Use in Creating Protein Nanostructures Duckworth, Benjamin P.; Chen, Yan; Wollack, James W. Angewandte Chemie International Edition, Vol. 46, Issue 46, p. 8819-8822 https://doi.org/10.1002/anie.200701942	journal	November 2007
Self-assembling protein arrays on DNA chips by auto-labeling fusion proteins with a single DNA address Jongsma, Maarten A.; Litjens, Ralph H. G. M. PROTEOMICS, Vol. 6, Issue 9, p. 2650-2655 https://doi.org/10.1002/pmic.200500654	journal	May 2006
Highly sensitive detectiong of DNA using enzyme-liked DNA-probe. I Colorimatric and fluorometric detection Murakami, Akira; Tada, Jun; Yamagate, Koichi Nucleic Acids Research, Vol. 17, Issue 14, p. 5587-5595 https://doi.org/10.1093/nar/17.14.5587	journal	January 1989
An enzymatic method for site-specific labeling of recombinant proteins with oligonucleotides Tominaga, Jo; Kemori, Yoshinori; Tanaka, Yusuke Chemical Communications, Vol. 0, Issue 4, p. 401-403 https://doi.org/10.1039/B613793H	journal	January 2007
Programmable Cell Adhesion Encoded by DNA Hybridization Chandra, Ravi A.; Douglas, Erik S.; Mathies, Richard A. Angewandte Chemie International Edition, Vol. 45, Issue 6, p. 896-901 https://doi.org/10.1002/anie.200502421	journal	January 2006
DNA modification of live cell surface Borisenko, Grigory G.; Zaitseva, Marina A.; Chuvilin, Andrey N. Nucleic Acids Research, Vol. 37, Issue 4, p. e28-e28 https://doi.org/10.1093/nar/gkn1034	journal	January 2009

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