Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)

Hamid, Ahmed M.; Prabhakaran, Aneesh; Garimella, Sandilya V. B.; Ibrahim, Yehia M.; Smith, Richard D.

doi:10.1016/j.ijms.2018.03.006

Title: Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)

Journal Article · Sun Jul 01 00:00:00 EDT 2018 · International Journal of Mass Spectrometry

DOI:https://doi.org/10.1016/j.ijms.2018.03.006· OSTI ID:1437536

Hamid, Ahmed M.; Prabhakaran, Aneesh; Garimella, Sandilya V. B.; Ibrahim, Yehia M.;

Ion mobility (IM) is rapidly gaining attention for the analysis of biomolecules due to the ability to distinguish the shapes of ions. However, conventional constant electric field drift tube IM has limited resolving power, constrained by practical limitations on the path length and maximum applied voltage. The implementation of traveling waves (TW) in IM removes the latter limitation, allowing higher resolution to be achieved using extended path lengths. These can be readily obtainable in structures for lossless ion manipulations (SLIM), which are fabricated from electric fields that are generated by appropriate potentials applied to arrays of electrodes patterned on two parallel surfaces. In this work we have investigated the relationship between the various SLIM variables, such as electrode dimensions, inter-surface gap, and the TW applied voltages, that directly impact the fields experienced by ions. Ion simulation and theoretical calculations have been utilized to understand the dependence of SLIM geometry and effective electric field. The variables explored impact both ion confinement and the observed IM resolution in Structures for Lossless Ion Manipulations (SLIM) modules.

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Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1437536

Report Number(s):: PNNL-SA-127372; 48680; 49531; KP1601010

Journal Information:: International Journal of Mass Spectrometry, Vol. 430, Issue C; ISSN 1387-3806

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

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Recommendations for reporting ion mobility Mass Spectrometry measurements Gabelica, Valérie; Shvartsburg, Alexandre A.; Afonso, Carlos Mass Spectrometry Reviews, Vol. 38, Issue 3 https://doi.org/10.1002/mas.21585	journal	October 2017
A simulation study of the influence of the traveling wave patterns on ion mobility separations in structures for lossless ion manipulations Li, Ailin; Garimella, Sandilya V. B.; Ibrahim, Yehia M. The Analyst, Vol. 145, Issue 1 https://doi.org/10.1039/c9an01509d	journal	January 2020

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