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Title: Capillary absorption spectrometer and process for isotopic analysis of small samples

Patent ·
OSTI ID:1436501
; ; ; ; ;

A capillary absorption spectrometer and process are described that provide highly sensitive and accurate stable absorption measurements of analytes in a sample gas that may include isotopologues of carbon and oxygen obtained from gas and biological samples. It further provides isotopic images of microbial communities that allow tracking of nutrients at the single cell level. It further targets naturally occurring variations in carbon and oxygen isotopes that avoids need for expensive isotopically labeled mixtures which allows study of samples taken from the field without modification. The process also permits sampling in vivo permitting real-time ambient studies of microbial communities.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
9,952,144
Application Number:
15/046,082
OSTI ID:
1436501
Resource Relation:
Patent File Date: 2016 Feb 17
Country of Publication:
United States
Language:
English

References (9)

Wavelength modulation spectroscopy method and system patent October 2006
Method and apparatus for locking a laser with a resonant cavity patent September 2013
Compositions and methods for detecting and quantifying gene expression patent-application October 2003
Elemental Analysis of Tagged Biologically Active Materials patent-application July 2008
Labeling Reagents and Methods of Their Use patent-application January 2009
DNA Sequence with Non-Fluorescent Nucleotide Reversible Terminators and Cleavable Label Modified Nucleotide Terminators patent-application February 2011
Electrochromic Window Fabrication Methods patent-application December 2012
Multi-photon Isomerisation of Combretastatins and Their Use in Therapy patent-application December 2015
A capillary absorption spectrometer for stable carbon isotope ratio (13C/12C) analysis in very small samples journal February 2012

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