skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Brain-specific enhancers for cell-based therapy

Abstract

Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.

Inventors:
; ;  [1]; ; ; ;
  1. (Jasmine)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1436498
Patent Number(s):
9,952,216
Application Number:
14/512,306
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Oct 10
Country of Publication:
United States
Language:
English

Citation Formats

Visel, Axel, Rubenstein, John L.R., Chen, Ying-Jiun, Pennacchio, Len A., Vogt, Daniel, Nicholas, Cory, and Kriegstein, Arnold. Brain-specific enhancers for cell-based therapy. United States: N. p., 2018. Web.
Visel, Axel, Rubenstein, John L.R., Chen, Ying-Jiun, Pennacchio, Len A., Vogt, Daniel, Nicholas, Cory, & Kriegstein, Arnold. Brain-specific enhancers for cell-based therapy. United States.
Visel, Axel, Rubenstein, John L.R., Chen, Ying-Jiun, Pennacchio, Len A., Vogt, Daniel, Nicholas, Cory, and Kriegstein, Arnold. Tue . "Brain-specific enhancers for cell-based therapy". United States. doi:. https://www.osti.gov/servlets/purl/1436498.
@article{osti_1436498,
title = {Brain-specific enhancers for cell-based therapy},
author = {Visel, Axel and Rubenstein, John L.R. and Chen, Ying-Jiun and Pennacchio, Len A. and Vogt, Daniel and Nicholas, Cory and Kriegstein, Arnold},
abstractNote = {Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 24 00:00:00 EDT 2018},
month = {Tue Apr 24 00:00:00 EDT 2018}
}

Patent:

Save / Share: