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Title: Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease

Abstract

Coregistering quantitative high-resolution metal imaging with fluorescence imaging identifies copper accumulation in megamitochondria within intact neuroretinal slices.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3];  [1];  [1];  [1]; ORCiD logo [2]; ORCiD logo [3]
  1. Department of Chemistry; University of California; Berkeley; USA
  2. Nuclear and Chemical Sciences Division; Lawrence Livermore National Laboratory; Livermore; USA
  3. Department of Chemistry; University of California; Berkeley; USA; Howard Hughes Medical Institute
Publication Date:
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23). Biological Systems Science Division; National Institutes of Health (NIH); Fannie and John Hertz Foundation; Canadian Inst. for Advanced Research (CIFAR)
OSTI Identifier:
1434089
Grant/Contract Number:  
AC52-07NA27344; GM 79465; T32 GM066698; SCW1039
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Metallomics
Additional Journal Information:
Journal Name: Metallomics Journal Volume: 10 Journal Issue: 3; Journal ID: ISSN 1756-5901
Publisher:
Royal Society of Chemistry
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Ackerman, Cheri M., Weber, Peter K., Xiao, Tong, Thai, Bao, Kuo, Tiffani J., Zhang, Emily, Pett-Ridge, Jennifer, and Chang, Christopher J. Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease. United Kingdom: N. p., 2018. Web. doi:10.1039/C7MT00349H.
Ackerman, Cheri M., Weber, Peter K., Xiao, Tong, Thai, Bao, Kuo, Tiffani J., Zhang, Emily, Pett-Ridge, Jennifer, & Chang, Christopher J. Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease. United Kingdom. doi:10.1039/C7MT00349H.
Ackerman, Cheri M., Weber, Peter K., Xiao, Tong, Thai, Bao, Kuo, Tiffani J., Zhang, Emily, Pett-Ridge, Jennifer, and Chang, Christopher J. Tue . "Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease". United Kingdom. doi:10.1039/C7MT00349H.
@article{osti_1434089,
title = {Multimodal LA-ICP-MS and nanoSIMS imaging enables copper mapping within photoreceptor megamitochondria in a zebrafish model of Menkes disease},
author = {Ackerman, Cheri M. and Weber, Peter K. and Xiao, Tong and Thai, Bao and Kuo, Tiffani J. and Zhang, Emily and Pett-Ridge, Jennifer and Chang, Christopher J.},
abstractNote = {Coregistering quantitative high-resolution metal imaging with fluorescence imaging identifies copper accumulation in megamitochondria within intact neuroretinal slices.},
doi = {10.1039/C7MT00349H},
journal = {Metallomics},
number = 3,
volume = 10,
place = {United Kingdom},
year = {Tue Mar 06 00:00:00 EST 2018},
month = {Tue Mar 06 00:00:00 EST 2018}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on March 6, 2019
Publisher's Accepted Manuscript

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