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Title: Experimental Study of the Detection Limit in Dual-Gate Biosensors Using Ultrathin Silicon Transistors

Abstract

Dual-gate field-effect biosensors (bioFETs) with asymmetric gate capacitances were shown to surpass the Nernst limit of 59 mV/pH. However, previous studies have conflicting findings on the effect of the capacitive amplification scheme on the sensor detection limit, which is inversely proportional to the signal-to-noise ratio (SNR). In this paper, we present a systematic experimental investigation of the SNR using ultrathin silicon transistors. Our sensors operate at low voltage and feature asymmetric front and back oxide capacitances with asymmetry factors of 1.4 and 2.3. We demonstrate that in the dual-gate configuration, the response of our bioFETs to the pH change increases proportional to the asymmetry factor and indeed exceeds the Nernst limit. Further, our results reveal that the noise amplitude also increases in proportion to the asymmetry factor. We establish that the commensurate increase of the noise amplitude originates from the intrinsic low-frequency characteristic of the sensor noise, dominated by number fluctuation. Finally, these findings suggest that this capacitive signal amplification scheme does not improve the intrinsic detection limit of the dual-gate biosensors.

Authors:
 [1];  [1];  [1];  [2]; ORCiD logo [2]; ORCiD logo [1]
  1. New York Univ., Brooklyn, NY (United States). Dept. of Electrical and Computer Engineering
  2. Brookhaven National Lab. (BNL), Upton, NY (United States). Center for Functional Nanomaterials
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1433971
Report Number(s):
BNL-203506-2018-JAAM
Journal ID: ISSN 1936-0851
Grant/Contract Number:  
SC0012704
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
ACS Nano
Additional Journal Information:
Journal Volume: 11; Journal Issue: 7; Journal ID: ISSN 1936-0851
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 77 NANOSCIENCE AND NANOTECHNOLOGY; 42 ENGINEERING; bioFETs; biosensor; detection limit; silicon-on-insulator; super-Nernstian; ultrathin silicon

Citation Formats

Wu, Ting, Alharbi, Abdullah, You, Kai-Dyi, Kisslinger, Kim, Stach, Eric A., and Shahrjerdi, Davood. Experimental Study of the Detection Limit in Dual-Gate Biosensors Using Ultrathin Silicon Transistors. United States: N. p., 2017. Web. doi:10.1021/acsnano.7b02986.
Wu, Ting, Alharbi, Abdullah, You, Kai-Dyi, Kisslinger, Kim, Stach, Eric A., & Shahrjerdi, Davood. Experimental Study of the Detection Limit in Dual-Gate Biosensors Using Ultrathin Silicon Transistors. United States. doi:10.1021/acsnano.7b02986.
Wu, Ting, Alharbi, Abdullah, You, Kai-Dyi, Kisslinger, Kim, Stach, Eric A., and Shahrjerdi, Davood. Wed . "Experimental Study of the Detection Limit in Dual-Gate Biosensors Using Ultrathin Silicon Transistors". United States. doi:10.1021/acsnano.7b02986. https://www.osti.gov/servlets/purl/1433971.
@article{osti_1433971,
title = {Experimental Study of the Detection Limit in Dual-Gate Biosensors Using Ultrathin Silicon Transistors},
author = {Wu, Ting and Alharbi, Abdullah and You, Kai-Dyi and Kisslinger, Kim and Stach, Eric A. and Shahrjerdi, Davood},
abstractNote = {Dual-gate field-effect biosensors (bioFETs) with asymmetric gate capacitances were shown to surpass the Nernst limit of 59 mV/pH. However, previous studies have conflicting findings on the effect of the capacitive amplification scheme on the sensor detection limit, which is inversely proportional to the signal-to-noise ratio (SNR). In this paper, we present a systematic experimental investigation of the SNR using ultrathin silicon transistors. Our sensors operate at low voltage and feature asymmetric front and back oxide capacitances with asymmetry factors of 1.4 and 2.3. We demonstrate that in the dual-gate configuration, the response of our bioFETs to the pH change increases proportional to the asymmetry factor and indeed exceeds the Nernst limit. Further, our results reveal that the noise amplitude also increases in proportion to the asymmetry factor. We establish that the commensurate increase of the noise amplitude originates from the intrinsic low-frequency characteristic of the sensor noise, dominated by number fluctuation. Finally, these findings suggest that this capacitive signal amplification scheme does not improve the intrinsic detection limit of the dual-gate biosensors.},
doi = {10.1021/acsnano.7b02986},
journal = {ACS Nano},
number = 7,
volume = 11,
place = {United States},
year = {Wed Jun 21 00:00:00 EDT 2017},
month = {Wed Jun 21 00:00:00 EDT 2017}
}

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