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Title: Current understanding of the human microbiome

Abstract

Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes, and mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this Review we focus on studies in humans to describe these challenges, and propose strategies that leverage existing knowledge to move rapidly from correlation to causation, and ultimately to translation.

Authors:
; ORCiD logo; ; ; ; ORCiD logo
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1433770
Report Number(s):
PNNL-SA-132272
Journal ID: ISSN 1078-8956
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Nature Medicine
Additional Journal Information:
Journal Volume: 24; Journal Issue: 4; Journal ID: ISSN 1078-8956
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English

Citation Formats

Gilbert, Jack A., Blaser, Martin J., Caporaso, J. Gregory, Jansson, Janet K., Lynch, Susan V., and Knight, Rob. Current understanding of the human microbiome. United States: N. p., 2018. Web. doi:10.1038/nm.4517.
Gilbert, Jack A., Blaser, Martin J., Caporaso, J. Gregory, Jansson, Janet K., Lynch, Susan V., & Knight, Rob. Current understanding of the human microbiome. United States. doi:10.1038/nm.4517.
Gilbert, Jack A., Blaser, Martin J., Caporaso, J. Gregory, Jansson, Janet K., Lynch, Susan V., and Knight, Rob. Tue . "Current understanding of the human microbiome". United States. doi:10.1038/nm.4517.
@article{osti_1433770,
title = {Current understanding of the human microbiome},
author = {Gilbert, Jack A. and Blaser, Martin J. and Caporaso, J. Gregory and Jansson, Janet K. and Lynch, Susan V. and Knight, Rob},
abstractNote = {Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes, and mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this Review we focus on studies in humans to describe these challenges, and propose strategies that leverage existing knowledge to move rapidly from correlation to causation, and ultimately to translation.},
doi = {10.1038/nm.4517},
journal = {Nature Medicine},
issn = {1078-8956},
number = 4,
volume = 24,
place = {United States},
year = {2018},
month = {4}
}