RETRACTED: Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

Marshall, Richard S.; Vierstra, Richard D.

doi:10.7554/eLife.34532

Title: RETRACTED: Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

Journal Article · Fri Apr 06 00:00:00 EDT 2018 · eLife

DOI:https://doi.org/10.7554/eLife.34532· OSTI ID:1432090

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26S proteasome abundance is tightly regulated at multiple levels, including the elimination of excess or inactive particles by autophagy. In yeast, this proteaphagy occurs upon nitrogen starvation but not carbon starvation, which instead stimulates the rapid sequestration of proteasomes into cytoplasmic puncta termed proteasome storage granules (PSGs). Here, we show that PSGs help protect proteasomes from autophagic degradation. Both the core protease and regulatory particle sub-complexes are sequestered separately into PSGs via pathways dependent on the accessory proteins Blm10 and Spg5, respectively. Modulating PSG formation, either by perturbing cellular energy status or pH, or by genetically eliminating factors required for granule assembly, not only influences the rate of proteasome degradation, but also impacts cell viability upon recovery from carbon starvation. PSG formation and concomitant protection against proteaphagy also occurs in Arabidopsis , suggesting that PSGs represent an evolutionarily conserved cache of proteasomes that can be rapidly re-mobilized based on energy availability.

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Research Organization:: Univ. of Wisconsin, Madison, WI (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Science Foundation (NSF); National Institutes of Health )NIH)

Grant/Contract Number:: FG02-88ER13968

OSTI ID:: 1432090

Alternate ID(s):: OSTI ID: 1432092; OSTI ID: 1509811

Journal Information:: eLife, Journal Name: eLife Vol. 7; ISSN 2050-084X

Publisher:: eLife Sciences Publications, Ltd.Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 67 works

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