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Title: Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Authors:
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  1. Pfizer
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1431372
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Medicinal Chemistry; Journal Volume: 60; Journal Issue: 13
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Helal, Christopher J., Arnold, Eric P., Boyden, Tracey L., Chang, Cheng, Chappie, Thomas A., Fennell, Kimberly F., Forman, Michael D., Hajos, Mihaly, Harms, John F., Hoffman, William E., Humphrey, John M., Kang, Zhijun, Kleiman, Robin J., Kormos, Bethany L., Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O'Connor, Rebecca E., Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W., Schmidt, Christopher J., Ueno, Hirokazu, Verhoest, Patrick R., and Yang, Edward X. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. United States: N. p., 2017. Web. doi:10.1021/acs.jmedchem.7b00397.
Helal, Christopher J., Arnold, Eric P., Boyden, Tracey L., Chang, Cheng, Chappie, Thomas A., Fennell, Kimberly F., Forman, Michael D., Hajos, Mihaly, Harms, John F., Hoffman, William E., Humphrey, John M., Kang, Zhijun, Kleiman, Robin J., Kormos, Bethany L., Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O'Connor, Rebecca E., Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W., Schmidt, Christopher J., Ueno, Hirokazu, Verhoest, Patrick R., & Yang, Edward X. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. United States. doi:10.1021/acs.jmedchem.7b00397.
Helal, Christopher J., Arnold, Eric P., Boyden, Tracey L., Chang, Cheng, Chappie, Thomas A., Fennell, Kimberly F., Forman, Michael D., Hajos, Mihaly, Harms, John F., Hoffman, William E., Humphrey, John M., Kang, Zhijun, Kleiman, Robin J., Kormos, Bethany L., Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O'Connor, Rebecca E., Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W., Schmidt, Christopher J., Ueno, Hirokazu, Verhoest, Patrick R., and Yang, Edward X. Fri . "Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor". United States. doi:10.1021/acs.jmedchem.7b00397.
@article{osti_1431372,
title = {Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor},
author = {Helal, Christopher J. and Arnold, Eric P. and Boyden, Tracey L. and Chang, Cheng and Chappie, Thomas A. and Fennell, Kimberly F. and Forman, Michael D. and Hajos, Mihaly and Harms, John F. and Hoffman, William E. and Humphrey, John M. and Kang, Zhijun and Kleiman, Robin J. and Kormos, Bethany L. and Lee, Che-Wah and Lu, Jiemin and Maklad, Noha and McDowell, Laura and Mente, Scot and O'Connor, Rebecca E. and Pandit, Jayvardhan and Piotrowski, Mary and Schmidt, Anne W. and Schmidt, Christopher J. and Ueno, Hirokazu and Verhoest, Patrick R. and Yang, Edward X.},
abstractNote = {},
doi = {10.1021/acs.jmedchem.7b00397},
journal = {Journal of Medicinal Chemistry},
number = 13,
volume = 60,
place = {United States},
year = {Fri Jun 16 00:00:00 EDT 2017},
month = {Fri Jun 16 00:00:00 EDT 2017}
}