Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Journal Article · Fri Jun 16 00:00:00 EDT 2017 · Journal of Medicinal Chemistry

DOI:https://doi.org/10.1021/acs.jmedchem.7b00397· OSTI ID:1431372

Helal, Christopher J.; Arnold, Eric P.; Boyden, Tracey L.; Chang, Cheng; Chappie, Thomas A.; Fennell, Kimberly F.; Forman, Michael D.; Hajos, Mihaly; Harms, John F.; Hoffman, William E.; Humphrey, John M.; Kang, Zhijun; Kleiman, Robin J.; Kormos, Bethany L.; Lee, Che-Wah; Lu, Jiemin; Maklad, Noha; McDowell, Laura; Mente, Scot; O'Connor, Rebecca E. ; Pandit, Jayvardhan; Piotrowski, Mary; Schmidt, Anne W.; Schmidt, Christopher J.; Ueno, Hirokazu; Verhoest, Patrick R.; Yang, Edward X. ^[1]

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1. Pfizer

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
• Sponsoring Organization: USDOE Office of Science (SC)
• OSTI ID: 1431372
• Journal Information: Journal of Medicinal Chemistry, Vol. 60, Issue 13; ISSN 0022-2623
• Publisher: American Chemical Society (ACS)
• Country of Publication: United States
• Language: ENGLISH