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Title: Mutations in iron-sulfur cluster proteins that improve xylose utilization

Abstract

There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.

Inventors:
; ; ;
Publication Date:
Research Org.:
Lallemand Hungary Liquidity Management LLC, Budapest, HU (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1429846
Patent Number(s):
9,920,312
Application Number:
14/821,955
Assignee:
Lallemand Hungary Liquidity Management LLC (Budapest, HU) EE-LIBRARY
DOE Contract Number:  
FC36-08GO18103; PS02-06ER64304
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Aug 10
Country of Publication:
Hungary
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Froehlich, Allan, Henningsen, Brooks, Covalla, Sean, and Zelle, Rintze M. Mutations in iron-sulfur cluster proteins that improve xylose utilization. Hungary: N. p., 2018. Web.
Froehlich, Allan, Henningsen, Brooks, Covalla, Sean, & Zelle, Rintze M. Mutations in iron-sulfur cluster proteins that improve xylose utilization. Hungary.
Froehlich, Allan, Henningsen, Brooks, Covalla, Sean, and Zelle, Rintze M. Tue . "Mutations in iron-sulfur cluster proteins that improve xylose utilization". Hungary. https://www.osti.gov/servlets/purl/1429846.
@article{osti_1429846,
title = {Mutations in iron-sulfur cluster proteins that improve xylose utilization},
author = {Froehlich, Allan and Henningsen, Brooks and Covalla, Sean and Zelle, Rintze M.},
abstractNote = {There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {Hungary},
year = {2018},
month = {3}
}

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Works referenced in this record:

Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2
journal, March 2014

  • Poor, C. B.; Wegner, S. V.; Li, H.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 11, p. 4043-4048
  • DOI: 10.1073/pnas.1318869111

Identification of FRA1 and FRA2 as Genes Involved in Regulating the Yeast Iron Regulon in Response to Decreased Mitochondrial Iron-Sulfur Cluster Synthesis
journal, February 2008

  • Kum�novics, Attila; Chen, Opal S.; Li, Liangtao
  • Journal of Biological Chemistry, Vol. 283, Issue 16, p. 10276-10286
  • DOI: 10.1074/jbc.M801160200

Yap5 Is an Iron-Responsive Transcriptional Activator That Regulates Vacuolar Iron Storage in Yeast
journal, December 2007

  • Li, L.; Bagley, D.; Ward, D. M.
  • Molecular and Cellular Biology, Vol. 28, Issue 4, p. 1326-1337
  • DOI: 10.1128/MCB.01219-07

Crystal structures of thermostable xylose isomerases from Thermus caldophilus and Thermus thermophilus: possible structural determinants of thermostability
journal, May 1999

  • Chang, Changsoo; Park, Byung Chul; Lee, Dae-Sil
  • Journal of Molecular Biology, Vol. 288, Issue 4, p. 623-634
  • DOI: 10.1006/jmbi.1999.2696

Structures of d-xylose isomerase from Arthrobacter strain B3728 containing the inhibitors xylitol and d-sorbitol at 2.5 � and 2.3 � resolution, respectively
journal, July 1989


Metabolic engineering of a xylose-isomerase-expressing strain for rapid anaerobic xylose fermentation
journal, February 2005


The xylose isomerase-encoding gene (xylA) of Clostridium thermosaccharolyticum: cloning, sequencing and phylogeny of Xy1A enzymes
journal, April 1994


Codon usage tabulated from international DNA sequence databases: status for the year 2000
journal, January 2000

  • Nakamura, Yasukazu; Gojobori, Takashi; Ikemura, Toshimichi
  • Nucleic Acids Research, Vol. 28, Issue 1, p. 292-292
  • DOI: 10.1093/nar/28.1.292

Iron sensing and regulation in Saccharomyces cerevisiae: Ironing out the mechanistic details
journal, December 2013

  • Outten, Caryn E.; Albetel, Angela-Nadia
  • Current Opinion in Microbiology, Vol. 16, Issue 6, p. 662-668
  • DOI: 10.1016/j.mib.2013.07.020

Isolation of xylose isomerases by sequence- and function-based screening from a soil metagenomic library
journal, January 2011

  • Parachin, N�dia; Gorwa-Grauslund, Marie F.
  • Biotechnology for Biofuels, Vol. 4, Article No. 9
  • DOI: 10.1186/1754-6834-4-9

Aft1p and Aft2p Mediate Iron-responsive Gene Expression in Yeast through Related Promoter Elements
journal, May 2003

  • Rutherford, Julian C.; Jaron, Shulamit; Winge, Dennis R.
  • Journal of Biological Chemistry, Vol. 278, Issue 30, p. 27636-27643
  • DOI: 10.1074/jbc.M300076200

The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications
journal, January 1987

  • Sharp, Paul M.; Li, Wen-Hsiung
  • Nucleic Acids Research, Vol. 15, Issue 3, p. 1281-1295
  • DOI: 10.1093/nar/15.3.1281

An efficient xylose-fermenting recombinant Saccharomyces cerevisiae strain obtained through adaptive evolution and its global transcription profile
journal, October 2012

  • Shen, Yu; Chen, Xiao; Peng, Bingyin
  • Applied Microbiology and Biotechnology, Vol. 96, Issue 4, p. 1079-1091
  • DOI: 10.1007/s00253-012-4418-0

Localization of the essential histidine and carboxylate group in d-xylose isomerases
journal, February 1990

  • Vangrysperre, W.; Van Damme, J.; Vandekerckhove, J.
  • Biochemical Journal, Vol. 265, Issue 3, p. 699-705
  • DOI: 10.1042/bj2650699

Engineering acidic Streptomyces rubiginosus D-xylose isomerase by rational enzyme design
journal, January 2014

  • Waltman, M. J.; Yang, Z. K.; Langan, P.
  • Protein Engineering Design and Selection, Vol. 27, Issue 2, p. 59-64
  • DOI: 10.1093/protein/gzt062