skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Nanospheres with a smectic hydrophobic core and an amorphous PEG hydrophilic shell: structural changes and implications for drug delivery

Journal Article · · Soft Matter
DOI:https://doi.org/10.1039/c7sm02472j· OSTI ID:1426244

The structural changes in nanospheres with a crystalline core and an amorphous diffuse shell were investigated by small-angle neutron scattering (SANS), small-, medium-, and wide-angle X-ray scattering (SAXS, MAXS and WAXS), and differential scanning calorimetry (DSC).

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
National Institutes of Health (NIH)
OSTI ID:
1426244
Journal Information:
Soft Matter, Vol. 14, Issue 8; ISSN 1744-683X
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
ENGLISH

References (32)

Nontoxic Block Copolymer Nanospheres:  Design and Characterization journal December 2004
Nano-engineering block copolymer aggregates for drug delivery journal November 1999
Biodegradable self-assembled PEG–PCL–PEG micelles for hydrophobic honokiol delivery: I. Preparation and characterization journal April 2010
Self-Assembly and Critical Aggregation Concentration Measurements of ABA Triblock Copolymers with Varying B Block Types: Model Development, Prediction, and Validation journal April 2016
Structure of Hydrated Poly( d , l -lactic acid) Studied with X-ray Diffraction and Molecular Simulation Methods journal May 2012
Cold crystallization of poly(ethylene glycol)–water systems journal December 2007
Microphase separated structures in the solid and molten states of double-crystal graft copolymers of polyethylene and poly(ethylene oxide) journal June 2008
Caprolactonic Poloxamer Analog:  PEG-PCL-PEG journal March 2005
Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers journal September 2008
Nanofluids mediating surface forces journal November 2012
Structural Studies of Polyethers, (-(CH 2 )m-O-) n . X. Crystal Structure of Poly(ethylene oxide) journal September 1973
Small-Angle Neutron Scattering Study of PEO−PPO−PEO Micelle Structure in the Unimer-to-Micelle Transition Region journal July 1997
Investigation of phase behavior and water binding in poly(alkylene oxide) solutions journal August 1980
Amphiphilic Block Copolymers in Structure-Controlled Nanomaterial Hybrids journal February 1998
Micellar Morphologies of Poly(ε-caprolactone)- b -poly(ethylene oxide) Block Copolymers in Water with a Crystalline Core journal October 2007
Tyrosine-derived nanospheres for enhanced topical skin penetration journal February 2008
Structure and design of polymeric surfactant-based drug delivery systems journal June 2001
Biodegradable polymeric nanoparticles based drug delivery systems journal January 2010
Polymer Micelles with Crystalline Cores for Thermally Triggered Release journal July 2012
Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone journal November 2005
Irena : tool suite for modeling and analysis of small-angle scattering journal February 2009
Formulation Strategy for the Delivery of Cyclosporine A: Comparison of Two Polymeric Nanospheres journal August 2015
Microphase separation in copolymers of hydrophilic PEG blocks and hydrophobic tyrosine-derived segments using simultaneous SAXS/WAXS/DSC journal August 2010
Melting of water/poly(ethylene oxide) systems journal October 1985
Biodegradable polymeric nanoparticles as drug delivery devices journal January 2001
A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes journal March 2007
Scattering from block copolymer micelles journal August 2002
Hydrophobic Drug Delivery by Self-Assembling Triblock Copolymer-Derived Nanospheres journal September 2005
Biodegradable nanoparticles of amphiphilic triblock copolymers based on poly(3-hydroxybutyrate) and poly(ethylene glycol) as drug carriers journal September 2006
Modelling small-angle scattering data from micelles journal August 2002
Shell Cross-Linked Nanoparticles Containing Hydrolytically Degradable, Crystalline Core Domains journal April 2000
Interaction between poly(ethylene glycol) and water as studied by differential scanning calorimetry journal January 2001