Why Do Membranes of Some Unhealthy Cells Adopt a Cubic Architecture?

Xiao, Qi; Wang, Zhichun; Williams, Dewight; Leowanawat, Pawaret; Peterca, Mihai; Sherman, Samuel E.; Zhang, Shaodong; Hammer, Daniel A.; Heiney, Paul A.; King, Steven R.; Markovitz, David M.; Andre, Sabine; Gabius, Hans-Joachim; Klein, Michael L.; Percec, Virgil

doi:10.1021/acscentsci.6b00284

Title: Why Do Membranes of Some Unhealthy Cells Adopt a Cubic Architecture?

Journal Article · Mon Dec 05 00:00:00 EST 2016 · ACS Central Science

DOI:https://doi.org/10.1021/acscentsci.6b00284· OSTI ID:1425620

^[1]; Wang, Zhichun ^[2]; Williams, Dewight ^[3]; Leowanawat, Pawaret ^[4];

^[4]; Sherman, Samuel E. ^[4]; Zhang, Shaodong ^[4]; Hammer, Daniel A. ^[5]; Heiney, Paul A. ^[6]; King, Steven R. ^[7]; Markovitz, David M. ^[7]; Andre, Sabine ^[8]; Gabius, Hans-Joachim ^[8]; Klein, Michael L. ^[9];

^[4]

Univ. of Pennsylvania, Philadelphia, PA (United States). Roy & Diana Vagelos Laboratories, Department of Chemistry
Univ. of Pennsylvania, Philadelphia, PA (United States). Department of Bioengineering
Univ. of Pennsylvania, Philadelphia, PA (United States). Electron Microscopy Resource Laboratory, Department of Biochemistry and Biophysics, Perelman School of Medicine
Univ. of Pennsylvania, Philadelphia, PA (United States). Roy & Diana Vagelos Laboratories, Department of Chemistry
Univ. of Pennsylvania, Philadelphia, PA (United States). Department of Bioengineering and Department of Chemical and Biomolecular Engineering
Univ. of Pennsylvania, Philadelphia, PA (United States). Department of Physics and Astronomy
Univ. of Michigan, Ann Arbor, MI (United States). Division of Infectious Diseases, Department of Internal Medicine, Program in Immunology
Ludwig-Maximilians-University, Munich (Germany). Institute of Physiological Chemistry, Faculty of Veterinary Medicine
Temple University, Philadelphia, PA (United States). Institute of Computational Molecular Science

Nonlamellar lipid arrangements, including cubosomes, appear in unhealthy cells, e.g., when they are subject to stress, starvation, or viral infection. The bioactivity of cubosomes—nanoscale particles exhibiting bicontinuous cubic structures—versus more common vesicles is an unexplored area due to lack of suitable model systems. Here, glycodendrimercubosomes (GDCs)—sugar-presenting cubosomes assembled from Janus glycodendrimers by simple injection into buffer—are proposed as mimics of biological cubic membranes. The bicontinuous cubic GDC architecture has been demonstrated by electron tomography. The stability of these GDCs in buffer enabled studies on lectin-dependent agglutination, revealing significant differences compared with the vesicular glycodendrimersome (GDS) counterpart. In particular, GDCs showed an increased activity toward concanavalin A, as well as an increased sensitivity and selectivity toward two variants of banana lectins, a wild-type and a genetically modified variant, which is not exhibited by GDSs. These results suggest that cells may adapt under unhealthy conditions by undergoing a transformation from lamellar to cubic membranes as a method of defense.

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Research Organization:: Univ. of Pennsylvania, Philadelphia, PA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Materials Sciences & Engineering Division

Grant/Contract Number:: SC0007063

OSTI ID:: 1425620

Journal Information:: ACS Central Science, Vol. 2, Issue 12; ISSN 2374-7943

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 32 works

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Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes Xiao, Qi; Ludwig, Anna-Kristin; Romanò, Cecilia Proceedings of the National Academy of Sciences, Vol. 115, Issue 11 https://doi.org/10.1073/pnas.1720055115	journal	January 2018
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