Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT

Diver, Melinda M.; Pedi, Leanne; Koide, Akiko; Koide, Shohei; Long, Stephen B.

doi:10.1038/nature25439

Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT

Journal Article · 17 January 2018 · Nature (London)

DOI:https://doi.org/10.1038/nature25439· OSTI ID:1424773

Diver, Melinda M.; Pedi, Leanne; Koide, Akiko; Koide, Shohei; Long, Stephen B.

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: NIHAHAOTHER

OSTI ID:: 1424773

Journal Information:: Nature (London), Vol. 553, Issue 7689; ISSN 0028-0836

Publisher:: Nature Publishing Group

Country of Publication:: United States

Language:: ENGLISH

References (39)

Protein prenylation: unique fats make their mark on biology Wang, Mei; Casey, Patrick J. Nature Reviews Molecular Cell Biology, Vol. 17, Issue 2 https://doi.org/10.1038/nrm.2015.11	journal	January 2016
Conservation and Functional Importance of Carbon–Oxygen Hydrogen Bonding in AdoMet-Dependent Methyltransferases Horowitz, Scott; Dirk, Lynnette M. A.; Yesselman, Joseph D. Journal of the American Chemical Society, Vol. 135, Issue 41 https://doi.org/10.1021/ja407140k	journal	October 2013
Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis Strong, M.; Sawaya, M. R.; Wang, S. Proceedings of the National Academy of Sciences, Vol. 103, Issue 21 https://doi.org/10.1073/pnas.0602606103	journal	May 2006
Targeting protein prenylation for cancer therapy Berndt, Norbert; Hamilton, Andrew D.; Sebti, Saïd M. Nature Reviews Cancer, Vol. 11, Issue 11 https://doi.org/10.1038/nrc3151	journal	October 2011
Linking Crystallographic Model and Data Quality Karplus, P. A.; Diederichs, K. Science, Vol. 336, Issue 6084 https://doi.org/10.1126/science.1218231	journal	May 2012
Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria Ibrahim, M. X.; Sayin, V. I.; Akula, M. K. Science, Vol. 340, Issue 6138 https://doi.org/10.1126/science.1238880	journal	May 2013
Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line Kilmartin, J. V. The Journal of Cell Biology, Vol. 93, Issue 3 https://doi.org/10.1083/jcb.93.3.576	journal	June 1982
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ Dharmaiah, Srisathiyanarayanan; Bindu, Lakshman; Tran, Timothy H. Proceedings of the National Academy of Sciences, Vol. 113, Issue 44 https://doi.org/10.1073/pnas.1615316113	journal	October 2016
Engineering of recombinant crystallization chaperones Koide, Shohei Current Opinion in Structural Biology, Vol. 19, Issue 4 https://doi.org/10.1016/j.sbi.2009.04.008	journal	August 2009
HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes Minor, Wladek; Cymborowski, Marcin; Otwinowski, Zbyszek Acta Crystallographica Section D Biological Crystallography, Vol. 62, Issue 8 https://doi.org/10.1107/S0907444906019949	journal	July 2006
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe Wright, L. P.; Court, H.; Mor, A. Molecular and Cellular Biology, Vol. 29, Issue 7 https://doi.org/10.1128/MCB.01719-08	journal	January 2009
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
Topological and Mutational Analysis of Saccharomyces cerevisiae Ste14p, Founding Member of the Isoprenylcysteine Carboxyl Methyltransferase Family Romano, Julia D.; Michaelis, Susan Molecular Biology of the Cell, Vol. 12, Issue 7 https://doi.org/10.1091/mbc.12.7.1957	journal	July 2001
The Isoprenoid Substrate Specificity of Isoprenylcysteine Carboxylmethyltransferase: DEVELOPMENT OF NOVEL INHIBITORS Anderson, Jessica L.; Henriksen, Brian S.; Gibbs, Richard A. Journal of Biological Chemistry, Vol. 280, Issue 33 https://doi.org/10.1074/jbc.M504982200	journal	June 2005
Accelerating phage-display library selection by reversible and site-specific biotinylation Koide, A.; Wojcik, J.; Gilbreth, R. N. Protein Engineering Design and Selection, Vol. 22, Issue 11 https://doi.org/10.1093/protein/gzp053	journal	September 2009
Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT Court, Helen; Ahearn, Ian M.; Amoyel, Marc The Journal of Cell Biology, Vol. 216, Issue 12 https://doi.org/10.1083/jcb.201701053	journal	October 2017
Reaction path of protein farnesyltransferase at atomic resolution Long, Stephen B.; Casey, Patrick J.; Beese, Lorena S. Nature, Vol. 419, Issue 6907 https://doi.org/10.1038/nature00986	journal	October 2002
Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms Lau, H. Y.; Tang, J.; Casey, P. J. Oncogene, Vol. 36, Issue 27 https://doi.org/10.1038/onc.2016.508	journal	February 2017
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Proof of dual-topology architecture of Fluc F− channels with monobody blockers Stockbridge, Randy B.; Koide, Akiko; Miller, Christopher Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms6120	journal	October 2014
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras Wang, Tim; Yu, Haiyan; Hughes, Nicholas W. Cell, Vol. 168, Issue 5 https://doi.org/10.1016/j.cell.2017.01.013	journal	February 2017
Version 1.2 of the Crystallography and NMR system Brunger, Axel T. Nature Protocols, Vol. 2, Issue 11 https://doi.org/10.1038/nprot.2007.406	journal	October 2007
Functional Oligomerization of the Saccharomyces cerevisiae Isoprenylcysteine Carboxyl Methyltransferase, Ste14p Griggs, Amy M.; Hahne, Kalub; Hrycyna, Christine A. Journal of Biological Chemistry, Vol. 285, Issue 18 https://doi.org/10.1074/jbc.M109.061366	journal	March 2010
Mutational Analysis of the Integral Membrane Methyltransferase Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Reveals Potential Substrate Binding Sites Diver, Melinda M.; Long, Stephen B. Journal of Biological Chemistry, Vol. 289, Issue 38 https://doi.org/10.1074/jbc.M114.585125	journal	July 2014
Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains Sha, F.; Gencer, E. B.; Georgeon, S. Proceedings of the National Academy of Sciences, Vol. 110, Issue 37 https://doi.org/10.1073/pnas.1303640110	journal	August 2013
Progeria: A Paradigm for Translational Medicine Gordon, Leslie B.; Rothman, Frank G.; López-Otín, Carlos Cell, Vol. 156, Issue 3 https://doi.org/10.1016/j.cell.2013.12.028	journal	January 2014
Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0 Bricogne, G.; Vonrhein, C.; Flensburg, C. Acta Crystallographica Section D Biological Crystallography, Vol. 59, Issue 11 https://doi.org/10.1107/S0907444903017694	journal	October 2003
Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum Li, Xiaochun; Roberti, Rita; Blobel, Günter Nature, Vol. 517, Issue 7532 https://doi.org/10.1038/nature13797	journal	October 2014
Crystallizing membrane proteins using lipidic mesophases Caffrey, Martin; Cherezov, Vadim Nature Protocols, Vol. 4, Issue 5 https://doi.org/10.1038/nprot.2009.31	journal	April 2009
Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates Pérez-Sala, D.; Gilbert, B. A.; Tan, E. W. Biochemical Journal, Vol. 284, Issue 3 https://doi.org/10.1042/bj2840835	journal	June 1992
Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase ICMT Yang, Jing; Kulkarni, Kiran; Manolaridis, Ioannis Molecular Cell, Vol. 44, Issue 6 https://doi.org/10.1016/j.molcel.2011.10.020	journal	December 2011
Drugging the undruggable RAS: Mission Possible? Cox, Adrienne D.; Fesik, Stephen W.; Kimmelman, Alec C. Nature Reviews Drug Discovery, Vol. 13, Issue 11 https://doi.org/10.1038/nrd4389	journal	October 2014
Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold Koide, Akiko; Wojcik, John; Gilbreth, Ryan N. Journal of Molecular Biology, Vol. 415, Issue 2 https://doi.org/10.1016/j.jmb.2011.12.019	journal	January 2012
A dimerization motif for transmembrane α–helices Lemmon, Mark A.; Treutlein, Herbert R.; Adams, Paul D. Nature Structural Biology, Vol. 1, Issue 3 https://doi.org/10.1038/nsb0394-157	journal	March 1994
Fluorescence-Detection Size-Exclusion Chromatography for Precrystallization Screening of Integral Membrane Proteins Kawate, Toshimitsu; Gouaux, Eric Structure, Vol. 14, Issue 4 https://doi.org/10.1016/j.str.2006.01.013	journal	April 2006
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
Mammalian Prenylcysteine Carboxyl Methyltransferase Is in the Endoplasmic Reticulum Dai, Qun; Choy, Edwin; Chiu, Vi Journal of Biological Chemistry, Vol. 273, Issue 24 https://doi.org/10.1074/jbc.273.24.15030	journal	June 1998
Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel Long, S. B. Science, Vol. 309, Issue 5736 https://doi.org/10.1126/science.1116269	journal	August 2005

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