Bringing diffuse X-ray scattering into focus
Journal Article
·
· Current Opinion in Structural Biology
X-ray crystallography is experiencing a renaissance as a method for probing the protein conformational ensemble. The inherent limitations of Bragg analysis, however, which only reveals the mean structure, have given way to a surge in interest in diffuse scattering, which is caused by structure variations. Diffuse scattering is present in all macromolecular crystallography experiments. Recent studies are shedding light on the origins of diffuse scattering in protein crystallography, and provide clues for leveraging diffuse scattering to model protein motions with atomic detail.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC52-06NA25396
- OSTI ID:
- 1633124
- Alternate ID(s):
- OSTI ID: 1422967
- Report Number(s):
- LA-UR-17-30486; S0959440X1730180X; PII: S0959440X1730180X
- Journal Information:
- Current Opinion in Structural Biology, Journal Name: Current Opinion in Structural Biology Vol. 50 Journal Issue: C; ISSN 0959-440X
- Publisher:
- ElsevierCopyright Statement
- Country of Publication:
- United Kingdom
- Language:
- English
Cited by: 14 works
Citation information provided by
Web of Science
Web of Science
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journal | December 2019 |
Rigid-body motion is the main source of diffuse scattering in protein crystallography
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journal | February 2019 |
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
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journal | October 2019 |
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journal | June 2019 |
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