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Title: Chimeric OspA genes, proteins and methods of use thereof

Abstract

The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.

Inventors:
; ; ; ; ;
Publication Date:
Research Org.:
Research Foundation of the State University of New York, Amherst, NY; Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1422826
Patent Number(s):
9,895,434
Application Number:
15/049,438
Assignee:
Brookhaven Science Associates, LLC (Upton, NY) BNL
DOE Contract Number:  
DE-SC0012704
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Feb 22
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Crowe, Brian A., Livey, Ian, O'Rourke, Maria, Schwendinger, Michael, Dunn, John J., and Luft, Benjamin J. Chimeric OspA genes, proteins and methods of use thereof. United States: N. p., 2018. Web.
Crowe, Brian A., Livey, Ian, O'Rourke, Maria, Schwendinger, Michael, Dunn, John J., & Luft, Benjamin J. Chimeric OspA genes, proteins and methods of use thereof. United States.
Crowe, Brian A., Livey, Ian, O'Rourke, Maria, Schwendinger, Michael, Dunn, John J., and Luft, Benjamin J. Tue . "Chimeric OspA genes, proteins and methods of use thereof". United States. https://www.osti.gov/servlets/purl/1422826.
@article{osti_1422826,
title = {Chimeric OspA genes, proteins and methods of use thereof},
author = {Crowe, Brian A. and Livey, Ian and O'Rourke, Maria and Schwendinger, Michael and Dunn, John J. and Luft, Benjamin J.},
abstractNote = {The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 20 00:00:00 EST 2018},
month = {Tue Feb 20 00:00:00 EST 2018}
}

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