Chimeric OspA genes, proteins and methods of use thereof

Crowe, Brian A.; Livey, Ian; O'Rourke, Maria; Schwendinger, Michael; Dunn, John J.; Luft, Benjamin J.

Chimeric OspA genes, proteins and methods of use thereof

Patent · 20 February 2018

OSTI ID:1422826

Crowe, Brian A.; Livey, Ian; O'Rourke, Maria; Schwendinger, Michael; Dunn, John J.; Luft, Benjamin J.

The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.

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Research Organization:: Research Foundation of the State University of New York, Amherst, NY; Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: SC0012704;

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Number(s):: 9,895,434

Application Number:: 15/049,438

OSTI ID:: 1422826

Country of Publication:: United States

Language:: English

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