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Title: Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery

Abstract

A diketopyrrolopyrrole-based semiconducting polymer nanoparticle (PDFT1032) has been developed as a NIR-II (near infrared window II, 1000–1700 nm) fluorescent probe. It shows high photostability, a favorable absorption peak at 809 nm, a large Stokes shift of 223 nm, outstanding biocompatibility and minimal in vivo toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution. Overall, excellent biocompatibility, favorable hydrophilicity, and desirable chemical and optical properties make the semiconducting polymer nanoparticle PDFT1032 a highly promising NIR-II imaging probe with the potential to be widely applicable in clinical imaging and the surgical treatment of malignancy.

Authors:
 [1];  [2];  [3];  [3]; ORCiD logo [3]; ORCiD logo [4]; ORCiD logo [2];  [5]; ORCiD logo [3]
  1. Wuhan Univ., Wuhan (China). Zhongnan Hospital, Dept. of Orthopedics; Stanford Univ., CA (United States). Canary Center at Stanford for Cancer Early Detection, Dept. of Radiology, Molecular Imaging Program at Stanford (MIPS)
  2. Nanjing Univ. of Posts & Telecommunications, Nanjing (China). Key Lab. for Organic Electronics and Information Displays, Inst. of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)
  3. Stanford Univ., CA (United States). Canary Center at Stanford for Cancer Early Detection, Dept. of Radiology, Molecular Imaging Program at Stanford (MIPS)
  4. Chinese Academy of Sciences (CAS), Shanghai (China). CAS Key Lab. of Receptor Research, Synthetic Organic & Medicinal Chemistry Lab. (SOMCL), Shanghai Inst. of Materia Medica
  5. Wuhan Univ., Wuhan (China). Zhongnan Hospital, Dept. of Orthopedics
Publication Date:
Research Org.:
Stanford Univ., CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); National Natural Science Foundation of China (NNSFC)
OSTI Identifier:
1421775
Alternate Identifier(s):
OSTI ID: 1505220
Grant/Contract Number:  
SC0008397; GJHZ1622
Resource Type:
Journal Article: Published Article
Journal Name:
Chemical Science
Additional Journal Information:
Journal Volume: 9; Journal Issue: 12; Journal ID: ISSN 2041-6520
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES

Citation Formats

Shou, Kangquan, Tang, Yufu, Chen, Hao, Chen, Si, Zhang, Lei, Zhang, Ao, Fan, Quli, Yu, Aixi, and Cheng, Zhen. Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery. United States: N. p., 2018. Web. doi:10.1039/c8sc00206a.
Shou, Kangquan, Tang, Yufu, Chen, Hao, Chen, Si, Zhang, Lei, Zhang, Ao, Fan, Quli, Yu, Aixi, & Cheng, Zhen. Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery. United States. doi:10.1039/c8sc00206a.
Shou, Kangquan, Tang, Yufu, Chen, Hao, Chen, Si, Zhang, Lei, Zhang, Ao, Fan, Quli, Yu, Aixi, and Cheng, Zhen. Tue . "Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery". United States. doi:10.1039/c8sc00206a.
@article{osti_1421775,
title = {Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery},
author = {Shou, Kangquan and Tang, Yufu and Chen, Hao and Chen, Si and Zhang, Lei and Zhang, Ao and Fan, Quli and Yu, Aixi and Cheng, Zhen},
abstractNote = {A diketopyrrolopyrrole-based semiconducting polymer nanoparticle (PDFT1032) has been developed as a NIR-II (near infrared window II, 1000–1700 nm) fluorescent probe. It shows high photostability, a favorable absorption peak at 809 nm, a large Stokes shift of 223 nm, outstanding biocompatibility and minimal in vivo toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution. Overall, excellent biocompatibility, favorable hydrophilicity, and desirable chemical and optical properties make the semiconducting polymer nanoparticle PDFT1032 a highly promising NIR-II imaging probe with the potential to be widely applicable in clinical imaging and the surgical treatment of malignancy.},
doi = {10.1039/c8sc00206a},
journal = {Chemical Science},
issn = {2041-6520},
number = 12,
volume = 9,
place = {United States},
year = {2018},
month = {2}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1039/c8sc00206a

Citation Metrics:
Cited by: 11 works
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