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Title: A Numerical Model of Exchange Chromatography Through 3D Lattice Structures

Abstract

Rapid progress in the development of additive manufacturing technologies is opening new opportunities to fabricate structures that control mass transport in three dimensions across a broad range of length scales. We describe a structure that can be fabricated by newly available commercial 3D printers. It contains an array of regular three-dimensional flow paths that are in intimate contact with a solid phase, and thoroughly shuffle material among the paths. We implement a chemically reacting flow model to study its behavior as an exchange chromatography column, and compare it to an array of one-dimensional flow paths that resemble more traditional honeycomb monoliths. A reaction front moves through the columns and then elutes. Here, the front is sharper at all flow rates for the structure with three-dimensional flow paths, and this structure is more robust to channel width defects than the one-dimensional array.

Authors:
ORCiD logo [1];  [1]
  1. Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1421768
Alternate Identifier(s):
OSTI ID: 1422267
Report Number(s):
SAND-2018-1363J
Journal ID: ISSN 0001-1541; 660572
Grant/Contract Number:
AC04-94AL85000; NA-0003525
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
AIChE Journal
Additional Journal Information:
Journal Volume: 64; Journal Issue: 5; Journal ID: ISSN 0001-1541
Publisher:
American Institute of Chemical Engineers
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING

Citation Formats

Salloum, Maher, and Robinson, David B. A Numerical Model of Exchange Chromatography Through 3D Lattice Structures. United States: N. p., 2018. Web. doi:10.1002/aic.16108.
Salloum, Maher, & Robinson, David B. A Numerical Model of Exchange Chromatography Through 3D Lattice Structures. United States. doi:10.1002/aic.16108.
Salloum, Maher, and Robinson, David B. Tue . "A Numerical Model of Exchange Chromatography Through 3D Lattice Structures". United States. doi:10.1002/aic.16108.
@article{osti_1421768,
title = {A Numerical Model of Exchange Chromatography Through 3D Lattice Structures},
author = {Salloum, Maher and Robinson, David B.},
abstractNote = {Rapid progress in the development of additive manufacturing technologies is opening new opportunities to fabricate structures that control mass transport in three dimensions across a broad range of length scales. We describe a structure that can be fabricated by newly available commercial 3D printers. It contains an array of regular three-dimensional flow paths that are in intimate contact with a solid phase, and thoroughly shuffle material among the paths. We implement a chemically reacting flow model to study its behavior as an exchange chromatography column, and compare it to an array of one-dimensional flow paths that resemble more traditional honeycomb monoliths. A reaction front moves through the columns and then elutes. Here, the front is sharper at all flow rates for the structure with three-dimensional flow paths, and this structure is more robust to channel width defects than the one-dimensional array.},
doi = {10.1002/aic.16108},
journal = {AIChE Journal},
number = 5,
volume = 64,
place = {United States},
year = {Tue Jan 30 00:00:00 EST 2018},
month = {Tue Jan 30 00:00:00 EST 2018}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on January 30, 2019
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