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Characterization of the PB2 Cap Binding Domain Accelerates Inhibitor Design

Journal Article · · Crystals
DOI:https://doi.org/10.3390/cryst8020062· OSTI ID:1419869
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
FOREIGN
OSTI ID:
1419869
Journal Information:
Crystals, Vol. 8, Issue 2; ISSN 2073-4352
Publisher:
MDPI
Country of Publication:
United States
Language:
ENGLISH

References (23)

The cap-binding site of influenza virus protein PB2 as a drug target January 2016
Cap-Dependent Translation Initiation in Eukaryotes Is Regulated by a Molecular Mimic of eIF4G June 1999
A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription March 1981
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit February 2009
Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G July 2014
The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits April 2001
The Crystal Structure of the PB2 Cap-binding Domain of Influenza B Virus Reveals a Novel Cap Recognition Mechanism February 2015
New 7-Methylguanine Derivatives Targeting the Influenza Polymerase PB2 Cap-Binding Domain October 2013
Overview of the CCP 4 suite and current developments March 2011
Structural insight into cap-snatching and RNA synthesis by influenza polymerase November 2014
The structural basis for cap binding by influenza virus polymerase subunit PB2 May 2008
Coot model-building tools for molecular graphics November 2004
Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2 July 2014
XDS January 2010
A new promoter-binding site in the PB1 subunit of the influenza A virus polymerase March 2006
UCSF Chimera?A visualization system for exploratory research and analysis January 2004
Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation January 2014
[20] Processing of X-ray diffraction data collected in oscillation mode January 1997
Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site February 2009
PHENIX: a comprehensive Python-based system for macromolecular structure solution January 2010
Large-scale induced fit recognition of an m7GpppG cap analogue by the human nuclear cap-binding complex October 2002
Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase May 2009
Structural and Functional Characterization of K339T Substitution Identified in the PB2 Subunit Cap-binding Pocket of Influenza A Virus February 2013

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