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Title: An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery: An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery

Authors:
 [1];  [2];  [3]; ORCiD logo [4]
  1. Modeling and Simulation, Idaho National Laboratory, P.O. Box 1625 Idaho Falls ID 83415-3840 USA
  2. School of Medicine, University of Colorado Denver, Aurora CO 80045-7109 USA
  3. Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio TX 78249 USA
  4. Department of Computer Science, University of Colorado Boulder, Boulder CO 80309-0430 USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1419356
Grant/Contract Number:
AC07-05ID14517
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
International Journal for Numerical Methods in Biomedical Engineering
Additional Journal Information:
Related Information: CHORUS Timestamp: 2018-02-02 02:59:39; Journal ID: ISSN 2040-7939
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Kong, Fande, Kheyfets, Vitaly, Finol, Ender, and Cai, Xiao-Chuan. An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery: An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery. United Kingdom: N. p., 2018. Web. doi:10.1002/cnm.2952.
Kong, Fande, Kheyfets, Vitaly, Finol, Ender, & Cai, Xiao-Chuan. An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery: An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery. United Kingdom. doi:10.1002/cnm.2952.
Kong, Fande, Kheyfets, Vitaly, Finol, Ender, and Cai, Xiao-Chuan. 2018. "An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery: An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery". United Kingdom. doi:10.1002/cnm.2952.
@article{osti_1419356,
title = {An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery: An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery},
author = {Kong, Fande and Kheyfets, Vitaly and Finol, Ender and Cai, Xiao-Chuan},
abstractNote = {},
doi = {10.1002/cnm.2952},
journal = {International Journal for Numerical Methods in Biomedical Engineering},
number = ,
volume = ,
place = {United Kingdom},
year = 2018,
month = 2
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on February 2, 2019
Publisher's Accepted Manuscript

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  • To assess the clinical usefulness of radionuclide-determined changes in pulmonary blood volume in patients with or without substantial coronary-artery disease, we determined the ratio of pulmonary blood volume at rest as compared with that during exercise. We used multigated blood-pool images obtained at rest and during supine exercise to determine the blood-volume ratio in patients subsequently undergoing coronary arteriography for evaluation of chest pain. Exercise tests were performed by use of a submaximal-workload protocol, although all tests were limited according to each patient's symptoms. The mean exercise/rest pulmonary-blood-volume ratios were lower for persons without coronary-artery disease (0.94 +- 0.06 (S.D.),more » 10 patients) and for those with disease confined to the right coronary artery (0.99 +- 0.12, five patients), as compared with all others with coronary-artery disease (1.14 +- 0.15, 37 patients) (P < 0.01). A pulmonary-blood-volume ratio equal to or greater than 1.06 had a sensitivity of 79%. Patients with coronary-artery disease not confined to the right coronary artery usually show an increase in pulmonary blood volume during supine exercise. No such change occurs in persons without coronary-artery disease.« less
  • Pulmonary artery aneurysms due to Behcet's disease are mainly seen in young males and very rarely in females. To our knowledge there are only 10 cases reported in the related literature. Emergent transcatheter embolization was performed in a female patient with a known history of Behcet's disease in whom massive hemoptysis developed because of rupture of a giant pulmonary artery aneurysm. At 6-month follow-up, transformation of the aneurysm sac into an air cavity was detected. To our knowledge, such a transformation has never been reported in the literature before. Embolization of the pulmonary artery aneurysm and the mechanism of cavitymore » transformation are reviewed and discussed.« less
  • Purpose: To demonstrate an efficient and clinically relevant patient specific QA method by reconstructing 3D patient dose from 2D EPID images for IMRT plans. Also to determine the usefulness of 2D QA metrics when assessing 3D patient dose deviations. Methods: Using the method developed by King et al (Med Phys 39(5),2839–2847), EPID images of IMRT fields were acquired in air and converted to dose at 10 cm depth (SAD setup) in a flat virtual water phantom. Each EPID measured dose map was then divided by the corresponding treatment planning system (TPS) dose map calculated with an identical setup, to derivemore » a 2D “error matrix”. For each field, the error matrix was used to adjust the doses along the respective ray lines in the original patient 3D dose. All field doses were combined to derive a reconstructed 3D patient dose for quantitative analysis. A software tool was developed to efficiently implement the entire process and was tested with a variety of IMRT plans for 2D (virtual flat phantom) and 3D (in-patient) QA analysis. Results: The method was tested on 60 IMRT plans. The mean (± standard deviation) 2D gamma (2%,2mm) pass rate (2D-GPR) was 97.4±3.0% and the mean 2D gamma index (2D-GI) was 0.35±0.06. The 3D PTV mean dose deviation was 1.8±0.8%. The analysis showed very weak correlations between both the 2D-GPR and 2D-GI when compared with PTV mean dose deviations (R2=0.3561 and 0.3632 respectively). Conclusion: Our method efficiently calculates 3D patient dose from 2D EPID images, utilising all of the advantages of an EPID-based dosimetry system. In this study, the 2D QA metrics did not predict the 3D patient dose deviation. This tool allows reporting of the 3D volumetric dose parameters thus providing more clinically relevant patient specific QA.« less
  • Exercise-induced increases in radionuclide-determined pulmonary blood volume (PBV) and thallium lung uptake have been described in patients with coronary artery disease (CAD) and have been shown to correlate with transient exercise-induced left ventricular dysfunction. To compare these 2 techniques in the same patients, 74 patients (59 with and 15 without significant CAD) underwent supine bicycle exercise twice on the same day--first for thallium myocardial and lung imaging and then for technetium-99m gated blood pool imaging for the PBV ratio determination. Thallium activity of lung and myocardium was determined to calculate thallium lung/heart ratio. Relative changes in PBV from rest tomore » exercise were expressed as a ratio of pulmonary counts (exercise/rest). Previously reported normal ranges for thallium lung/heart ratio and PBV ratio were used. The PBV ratio and thallium lung/heart ratio were abnormal in 71 and 36%, respectively, of patients with CAD (p less than 0.01). Both ratios were normal in all patients without CAD. Although the resting ejection fractions did not differ significantly in patients with normal versus those with abnormal PBV ratios or thallium lung/heart ratios, abnormal PBV ratios and thallium lung/heart ratios were associated with an exercise-induced decrease in ejection fraction. Propranolol use was significantly higher in patients with abnormal than in those with normal thallium lung/heart ratios (p less than 0.01). No significant difference in propranolol use was present in patients with abnormal or normal PBV ratios. In conclusion: (1) the prevalence of an abnormal thallium lung/heart ratio is less than that of the PBV ratio in patients with CAD; (2) both tests are normal in normal control subjects; (3) propranolol does not cause abnormal results in normal control subjects; however, propranolol may influence lung thallium uptake in patients with CAD; and (4) when both tests are abnormal, there is a high likelihood of multivessel disease.« less
  • A two-dimensional time-accurate Navier-Stokes solver for incompressible flows is used to simulate the effects of the axial spacing between an upstream rotor and a stator, and the wake/blade count ratio on turbomachinery unsteady flows. The code uses a pressure-based method. A low-Reynolds number two-equation turbulence model is incorporated to account for the turbulence effect. By computing cases with different spacing between an upstream rotor wake and a stator, the effect of the spacing is simulated. Wake/blade count ratio effect is simulated by varying the number of rotor wakes in one stator passage at the computational inlet plane. Results on surfacemore » pressure, unsteady velocity vectors, blade boundary layer profiles, rotor wake decay and loss coefficient for all the cases are interpreted. It is found that the unsteadiness in the stator blade passage increases with a decrease in the blade row spacing and a decrease in the wake/blade count ratio. The reduced frequency effect is dominant in the wake/blade count ratio simulation. The time averaged loss coefficient increases with a decrease in the axial blade row spacing and an increase in the wake/blade count ratio.« less