Effects of Atmospheric Pressure Plasmas on Isolated and Cellular DNA—A Review

Arjunan, Krishna; Sharma, Virender; Ptasinska, Sylwia

doi:10.3390/ijms16022971

Title: Effects of Atmospheric Pressure Plasmas on Isolated and Cellular DNA—A Review

Journal Article · Thu Jan 29 00:00:00 EST 2015 · International Journal of Molecular Sciences (Online)

DOI:https://doi.org/10.3390/ijms16022971· OSTI ID:1418861

Arjunan, Krishna; Sharma, Virender; Ptasinska, Sylwia

Atmospheric Pressure Plasma (APP) is being used widely in a variety of biomedical applications. Extensive research in the field of plasma medicine has shown the induction of DNA damage by APP in a dose-dependent manner in both prokaryotic and eukaryotic systems. Recent evidence suggests that APP-induced DNA damage shows potential benefits in many applications, such as sterilization and cancer therapy. However, in several other applications, such as wound healing and dentistry, DNA damage can be detrimental. This review reports on the extensive investigations devoted to APP interactions with DNA, with an emphasis on the critical role of reactive species in plasma-induced damage to DNA. The review consists of three main sections dedicated to fundamental knowledge of the interactions of reactive oxygen species (ROS)/reactive nitrogen species (RNS) with DNA and its components, as well as the effects of APP on isolated and cellular DNA in prokaryotes and eukaryotes.

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Research Organization:: University of Notre Dame, IN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FC02-04ER15533

OSTI ID:: 1418861

Alternate ID(s):: OSTI ID: 1628373

Journal Information:: International Journal of Molecular Sciences (Online), Journal Name: International Journal of Molecular Sciences (Online) Vol. 16 Journal Issue: 2; ISSN 1422-0067

Publisher:: MDPICopyright Statement

Country of Publication:: Switzerland

Language:: English

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Cited by: 109 works

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