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Title: Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering

Abstract

A large group of functional nanomaterials employed in biomedical applications, including targeted drug delivery, relies on amphiphilic polymers to encapsulate therapeutic payloads via self-assembly processes. Knowledge of the micelle structures will provide critical insights into design of polymeric drug delivery systems. Core–shell micelles composed of linear diblock copolymers poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL), poly(ethylene oxide)-b-poly(lactic acid) (PEG-b-PLA), as well as a heterografted brush consisting of a poly(glycidyl methacrylate) backbone with PEG and PLA branches (PGMA-g-PEG/PLA) were characterized by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS) measurements to gain structural information regarding the particle morphology, core–shell size, and aggregation number. The structural information at this quasi-equilibrium state can also be used as a reference when studying the kinetics of polymer micellization.

Authors:
 [1]; ORCiD logo [1];  [2];  [1];  [1];  [1];  [3];  [3];  [2];  [4]
  1. Department of Chemical Engineering, University of Illinois at Chicago, Chicago, Illinois 60607, United States
  2. Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States
  3. Department of Biological Sciences, Illinois Institute of Technology, Chicago, Illinois 60616, United States
  4. Department of Chemical Engineering, University of Illinois at Chicago, Chicago, Illinois 60607, United States; Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, United States
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1418031
Resource Type:
Journal Article
Resource Relation:
Journal Name: ACS Macro Letters; Journal Volume: 6; Journal Issue: 9
Country of Publication:
United States
Language:
ENGLISH
Subject:
36 MATERIALS SCIENCE

Citation Formats

Szymusiak, Magdalena, Kalkowski, Joseph, Luo, Hanying, Donovan, Alexander J., Zhang, Pin, Liu, Chang, Shang, Weifeng, Irving, Thomas, Herrera-Alonso, Margarita, and Liu, Ying. Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering. United States: N. p., 2017. Web. doi:10.1021/acsmacrolett.7b00490.
Szymusiak, Magdalena, Kalkowski, Joseph, Luo, Hanying, Donovan, Alexander J., Zhang, Pin, Liu, Chang, Shang, Weifeng, Irving, Thomas, Herrera-Alonso, Margarita, & Liu, Ying. Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering. United States. doi:10.1021/acsmacrolett.7b00490.
Szymusiak, Magdalena, Kalkowski, Joseph, Luo, Hanying, Donovan, Alexander J., Zhang, Pin, Liu, Chang, Shang, Weifeng, Irving, Thomas, Herrera-Alonso, Margarita, and Liu, Ying. Wed . "Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering". United States. doi:10.1021/acsmacrolett.7b00490.
@article{osti_1418031,
title = {Core–Shell Structure and Aggregation Number of Micelles Composed of Amphiphilic Block Copolymers and Amphiphilic Heterografted Polymer Brushes Determined by Small-Angle X-ray Scattering},
author = {Szymusiak, Magdalena and Kalkowski, Joseph and Luo, Hanying and Donovan, Alexander J. and Zhang, Pin and Liu, Chang and Shang, Weifeng and Irving, Thomas and Herrera-Alonso, Margarita and Liu, Ying},
abstractNote = {A large group of functional nanomaterials employed in biomedical applications, including targeted drug delivery, relies on amphiphilic polymers to encapsulate therapeutic payloads via self-assembly processes. Knowledge of the micelle structures will provide critical insights into design of polymeric drug delivery systems. Core–shell micelles composed of linear diblock copolymers poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL), poly(ethylene oxide)-b-poly(lactic acid) (PEG-b-PLA), as well as a heterografted brush consisting of a poly(glycidyl methacrylate) backbone with PEG and PLA branches (PGMA-g-PEG/PLA) were characterized by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS) measurements to gain structural information regarding the particle morphology, core–shell size, and aggregation number. The structural information at this quasi-equilibrium state can also be used as a reference when studying the kinetics of polymer micellization.},
doi = {10.1021/acsmacrolett.7b00490},
journal = {ACS Macro Letters},
number = 9,
volume = 6,
place = {United States},
year = {Wed Aug 16 00:00:00 EDT 2017},
month = {Wed Aug 16 00:00:00 EDT 2017}
}