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Title: Optical Encoding Technology for Viral Screening Panels Final Report CRADA No TC02132.0

Abstract

This was a collaborative effort between Lawrence Livermore National Security, LLC, Lawrence Livermore National Laboratory (LLNL) and Parallel Synthesis Technologies, Inc. (PSTI), to develop Optical Encoding Technology for Viral Screening Panels. The goal for this effort was to prepare a portable bead reader system that would enable the development of viral and bacterial screening panels which could be used for the detection of any desired set of bacteria or viruses in any location. The main objective was to determine if the combination of a bead-based, PCR suspension array technology, formulated from Parallume encoded beads and PSTI’s multiplex assay reader system (MARS), could provide advantages in terms of the number of simultaneously measured samples, portability, ruggedness, ease of use, accuracy, precision or cost as compared to the Luminexbased system developed at LLNL. The project underwent several no cost extensions however the overall goal of demonstrating the utility of this new system was achieved. As a result of the project a significant change to the type of bead PSTI used for the suspension system was implemented allowing better performance than the commercial Luminex system.

Authors:
 [1];  [1]
  1. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1417953
Report Number(s):
LLNL-TR-737037
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Lenhoff, R., and Haushalter, R. Optical Encoding Technology for Viral Screening Panels Final Report CRADA No TC02132.0. United States: N. p., 2017. Web. doi:10.2172/1417953.
Lenhoff, R., & Haushalter, R. Optical Encoding Technology for Viral Screening Panels Final Report CRADA No TC02132.0. United States. doi:10.2172/1417953.
Lenhoff, R., and Haushalter, R. Tue . "Optical Encoding Technology for Viral Screening Panels Final Report CRADA No TC02132.0". United States. doi:10.2172/1417953. https://www.osti.gov/servlets/purl/1417953.
@article{osti_1417953,
title = {Optical Encoding Technology for Viral Screening Panels Final Report CRADA No TC02132.0},
author = {Lenhoff, R. and Haushalter, R.},
abstractNote = {This was a collaborative effort between Lawrence Livermore National Security, LLC, Lawrence Livermore National Laboratory (LLNL) and Parallel Synthesis Technologies, Inc. (PSTI), to develop Optical Encoding Technology for Viral Screening Panels. The goal for this effort was to prepare a portable bead reader system that would enable the development of viral and bacterial screening panels which could be used for the detection of any desired set of bacteria or viruses in any location. The main objective was to determine if the combination of a bead-based, PCR suspension array technology, formulated from Parallume encoded beads and PSTI’s multiplex assay reader system (MARS), could provide advantages in terms of the number of simultaneously measured samples, portability, ruggedness, ease of use, accuracy, precision or cost as compared to the Luminexbased system developed at LLNL. The project underwent several no cost extensions however the overall goal of demonstrating the utility of this new system was achieved. As a result of the project a significant change to the type of bead PSTI used for the suspension system was implemented allowing better performance than the commercial Luminex system.},
doi = {10.2172/1417953},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {8}
}

Technical Report:

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