U.S. Department of EnergyOffice of Scientific and Technical Information
Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery
Abstract
Accurate tumor identification is essential in cancer management. Incomplete excision of tumor tissue, however, negatively affects the prognosis of the patient. To accomplish radical excision of tumor tissue, radiotracers can be used that target tumor tissue and can be detected using a gamma probe during surgery. Intraoperative fluorescence imaging could allow accurate real-time tumor delineation. Herein, a novel dual-modal imaging platform using base-catalyzed double addition of thiols into a propiolamide scaffold has been developed, allowing for the highly efficient and selective assembly of various thiol units in a protecting-group-free manner. The first small-molecule based αvβ3-targeted NIR-II/PET probe 68Ga-SCH2 was concisely generated via this strategy and subsequently evaluated in mice bearing the U87MG xenograft. Excellent imaging properties such as good tumor uptake, high tumor contrast and specificity, tumor delineation and image-guided surgery were achieved in the small animal models. These attractive results of 68Ga-SCH2 allow it to be a promising αvβ3-targeted NIR-II/PET probe for clinical translation.
- Authors:
-
[1]
- State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) and Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China
- Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Stanford University, USA
- Medical College, Tibet University, Lasa, China
- Hubei Provincial Key Laboratory of Developmentally Originated Disease, Center for Experimental Basic Medical Education, Wuhan University, Wuhan 430071, China
- Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China
- Publication Date:
- Research Org.:
- Stanford Univ., CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1417921
- Alternate Identifier(s):
- OSTI ID: 1506079
- Grant/Contract Number:
- SC0008397
- Resource Type:
- Journal Article: Published Article
- Journal Name:
- Chemical Science
- Additional Journal Information:
- Journal Name: Chemical Science Journal Volume: 9 Journal Issue: 8; Journal ID: ISSN 2041-6520
- Publisher:
- Royal Society of Chemistry (RSC)
- Country of Publication:
- United Kingdom
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
Sun, Yao, Zeng, Xiaodong, Xiao, Yuling, Liu, Changhao, Zhu, Hua, Zhou, Hui, Chen, Ziyang, Xu, Fuchun, Wang, Jule, Zhu, Mengyue, Wu, Junzhu, Tian, Mei, Zhang, Hong, Deng, Zixin, Cheng, Zhen, and Hong, Xuechuan. Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. United Kingdom: N. p., 2018.
Web. doi:10.1039/C7SC04774F.
Sun, Yao, Zeng, Xiaodong, Xiao, Yuling, Liu, Changhao, Zhu, Hua, Zhou, Hui, Chen, Ziyang, Xu, Fuchun, Wang, Jule, Zhu, Mengyue, Wu, Junzhu, Tian, Mei, Zhang, Hong, Deng, Zixin, Cheng, Zhen, & Hong, Xuechuan. Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. United Kingdom. https://doi.org/10.1039/C7SC04774F
Sun, Yao, Zeng, Xiaodong, Xiao, Yuling, Liu, Changhao, Zhu, Hua, Zhou, Hui, Chen, Ziyang, Xu, Fuchun, Wang, Jule, Zhu, Mengyue, Wu, Junzhu, Tian, Mei, Zhang, Hong, Deng, Zixin, Cheng, Zhen, and Hong, Xuechuan. 2018.
"Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery". United Kingdom. https://doi.org/10.1039/C7SC04774F.
@article{osti_1417921,
title = {Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery},
author = {Sun, Yao and Zeng, Xiaodong and Xiao, Yuling and Liu, Changhao and Zhu, Hua and Zhou, Hui and Chen, Ziyang and Xu, Fuchun and Wang, Jule and Zhu, Mengyue and Wu, Junzhu and Tian, Mei and Zhang, Hong and Deng, Zixin and Cheng, Zhen and Hong, Xuechuan},
abstractNote = {Accurate tumor identification is essential in cancer management. Incomplete excision of tumor tissue, however, negatively affects the prognosis of the patient. To accomplish radical excision of tumor tissue, radiotracers can be used that target tumor tissue and can be detected using a gamma probe during surgery. Intraoperative fluorescence imaging could allow accurate real-time tumor delineation. Herein, a novel dual-modal imaging platform using base-catalyzed double addition of thiols into a propiolamide scaffold has been developed, allowing for the highly efficient and selective assembly of various thiol units in a protecting-group-free manner. The first small-molecule based αvβ3-targeted NIR-II/PET probe 68Ga-SCH2 was concisely generated via this strategy and subsequently evaluated in mice bearing the U87MG xenograft. Excellent imaging properties such as good tumor uptake, high tumor contrast and specificity, tumor delineation and image-guided surgery were achieved in the small animal models. These attractive results of 68Ga-SCH2 allow it to be a promising αvβ3-targeted NIR-II/PET probe for clinical translation.},
doi = {10.1039/C7SC04774F},
url = {https://www.osti.gov/biblio/1417921},
journal = {Chemical Science},
issn = {2041-6520},
number = 8,
volume = 9,
place = {United Kingdom},
year = {Mon Jan 01 00:00:00 EST 2018},
month = {Mon Jan 01 00:00:00 EST 2018}
}
Free Publicly Available Full Text
Publisher's Version of Record at https://doi.org/10.1039/C7SC04774F
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 127 works
Citation information provided by
Web of Science
Web of Science
Figures / Tables:
Fig. 1: A new strategy for the construction of NIR-II dual-modal imaging probes. (a) The previous photo-catalyzed thiol-yne reaction; (b) the approach discussed in the present work.
All figures and tables
(6 total)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Development of a high quantum yield dye for tumour imaging
journal, January 2017
- Yang, Dan; Wang, Huasen; Sun, Chengjie
- Chemical Science, Vol. 8, Issue 9
Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery
journal, January 2017
- Sun, Yao; Ding, Mingmin; Zeng, Xiaodong
- Chemical Science, Vol. 8, Issue 5
Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes
journal, February 2016
- Gai, Yongkang; Xiang, Guangya; Ma, Xiang
- Bioconjugate Chemistry, Vol. 27, Issue 3
Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe
journal, April 2017
- Shou, Kangquan; Qu, Chunrong; Sun, Yao
- Advanced Functional Materials, Vol. 27, Issue 23
Multimodality Imaging Probes: Design and Challenges
journal, May 2010
- Louie, Angelique
- Chemical Reviews, Vol. 110, Issue 5
Novel Strategy for Preparing Dual-Modality Optical/PET Imaging Probes via Photo-Click Chemistry
journal, April 2016
- Sun, Lingyi; Ding, Jiule; Xing, Wei
- Bioconjugate Chemistry, Vol. 27, Issue 5
Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts
journal, June 2015
- Hoffman, Robert M.
- Nature Reviews Cancer, Vol. 15, Issue 8
UPAR targeted molecular imaging of cancers with small molecule-based probes
journal, October 2017
- Ding, Feng; Chen, Seng; Zhang, Wanshu
- Bioorganic & Medicinal Chemistry, Vol. 25, Issue 20
Improved disease-free survival and overall survival after fluorescence-guided surgery of liver metastasis in an orthotopic nude mouse model: Survival After Liver Metastasis FGS
journal, August 2015
- Murakami, Takashi; Hiroshima, Yukihiko; Zhang, Yong
- Journal of Surgical Oncology, Vol. 112, Issue 2
Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window
journal, January 2017
- Zhu, Shoujun; Yang, Qinglai; Antaris, Alexander L.
- Proceedings of the National Academy of Sciences, Vol. 114, Issue 5
Dual-Modality Image-Guided Surgery of Prostate Cancer with a Radiolabeled Fluorescent Anti-PSMA Monoclonal Antibody
journal, April 2014
- Lutje, S.; Rijpkema, M.; Franssen, G. M.
- Journal of Nuclear Medicine, Vol. 55, Issue 6
Clinical trial of combined radio- and fluorescence-guided sentinel lymph node biopsy in breast cancer: Multimodal sentinel lymph node biopsy in breast cancer
journal, May 2013
- Schaafsma, B. E.; Verbeek, F. P. R.; Rietbergen, D. D. D.
- British Journal of Surgery, Vol. 100, Issue 8
Concomitant radio- and fluorescence-guided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-99mTc-nanocolloid
journal, April 2012
- van den Berg, Nynke S.; Brouwer, Oscar R.; Klop, W. Martin C.
- European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, Issue 7
Organocatalytic, Regioselective Nucleophilic “Click” Addition of Thiols to Propiolic Acid Esters for Polymer-Polymer Coupling
journal, February 2013
- Truong, Vinh X.; Dove, Andrew P.
- Angewandte Chemie International Edition, Vol. 52, Issue 15
Flavylium Polymethine Fluorophores for Near- and Shortwave Infrared Imaging
journal, September 2017
- Cosco, Emily D.; Caram, Justin R.; Bruns, Oliver T.
- Angewandte Chemie International Edition, Vol. 56, Issue 42
Recyclable Cu( i )/melanin dots for cycloaddition, bioconjugation and cell labelling
journal, January 2016
- Sun, Yao; Hong, Suhyun; Ma, Xiaowei
- Chemical Science, Vol. 7, Issue 9
Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles
journal, January 2015
- Boros, Eszter; Bowen, Alice M.; Josephson, Lee
- Chemical Science, Vol. 6, Issue 1
Fluorescence-guided Surgery with a Fluorophore-conjugated Antibody to Carcinoembryonic Antigen (CEA), that Highlights the Tumor, Improves Surgical Resection and Increases Survival in Orthotopic Mouse Models of Human Pancreatic Cancer
journal, February 2014
- Metildi, Cristina A.; Kaushal, Sharmeela; Pu, Minya
- Annals of Surgical Oncology, Vol. 21, Issue 4
Ag 2 S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window
journal, April 2012
- Zhang, Yan; Hong, Guosong; Zhang, Yejun
- ACS Nano, Vol. 6, Issue 5
Through-skull fluorescence imaging of the brain in a new near-infrared window
journal, August 2014
- Hong, Guosong; Diao, Shuo; Chang, Junlei
- Nature Photonics, Vol. 8, Issue 9
Fluorescence-Guided Surgery Allows for More Complete Resection of Pancreatic Cancer, Resulting in Longer Disease-Free Survival Compared with Standard Surgery in Orthotopic Mouse Models
journal, July 2012
- Metildi, Cristina A.; Kaushal, Sharmeela; Hardamon, Chanae R.
- Journal of the American College of Surgeons, Vol. 215, Issue 1
Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes
journal, March 2015
- Sun, Yao; Ma, Xiaowei; Cheng, Kai
- Angewandte Chemie International Edition, Vol. 54, Issue 20
Improved positron emission tomography imaging of glioblastoma cancer using novel 68Ga-labeled peptides targeting the urokinase-type plasminogen activator receptor (uPAR)
journal, March 2017
- Loft, Mathias Dyrberg; Sun, Yao; Liu, Changhao
- Amino Acids, Vol. 49, Issue 6
A small-molecule dye for NIR-II imaging
journal, November 2015
- Antaris, Alexander L.; Chen, Hao; Cheng, Kai
- Nature Materials, Vol. 15, Issue 2
Sentinel Lymph Node Biopsy for Prostate Cancer: A Hybrid Approach
journal, March 2013
- van den Berg, N. S.; Valdes-Olmos, R. A.; van der Poel, H. G.
- Journal of Nuclear Medicine, Vol. 54, Issue 4
Near-Infrared-Fluorescence-Enhanced Molecular Imaging of Live Cells on Gold Substrates
journal, April 2011
- Hong, Guosong; Tabakman, Scott M.; Welsher, Kevin
- Angewandte Chemie International Edition, Vol. 50, Issue 20
A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer
journal, January 2014
- Wang, Yihong; Miao, Zheng; Ren, Gang
- Chem. Commun., Vol. 50, Issue 85
Imparting Multivalency to a Bifunctional Chelator: A Scaffold Design for Targeted PET Imaging Probes
journal, September 2009
- Liu, Wei; Hao, Guiyang; Long, Michael A.
- Angewandte Chemie International Edition, Vol. 48, Issue 40
Fluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model
journal, January 2013
- Metildi, Cristina A.; Kaushal, Sharmeela; Snyder, Cynthia S.
- Journal of Surgical Research, Vol. 179, Issue 1
Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer
journal, January 2016
- Sun, Yao; Qu, Chunrong; Chen, Hao
- Chemical Science, Vol. 7, Issue 9
Highly specific noninvasive photoacoustic and positron emission tomography of brain plaque with functionalized croconium dye labeled by a radiotracer
journal, January 2017
- Liu, Yajing; Yang, Yanping; Sun, Mingjian
- Chemical Science, Vol. 8, Issue 4
Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection
journal, January 2017
- Liu, Jie; Chen, Chao; Ji, Shenglu
- Chemical Science, Vol. 8, Issue 4
Multifunctional in vivo vascular imaging using near-infrared II fluorescence
journal, November 2012
- Hong, Guosong; Lee, Jerry C.; Robinson, Joshua T.
- Nature Medicine, Vol. 18, Issue 12
Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore
journal, June 2016
- Zhang, Xiao-Dong; Wang, Huasen; Antaris, Alexander L.
- Advanced Materials, Vol. 28, Issue 32
Live imaging of follicle stimulating hormone receptors in gonads and bones using near infrared II fluorophore
journal, January 2017
- Feng, Yi; Zhu, Shoujun; Antaris, Alexander L.
- Chemical Science, Vol. 8, Issue 5
Near-infrared fluorophores for biomedical imaging
journal, January 2017
- Hong, Guosong; Antaris, Alexander L.; Dai, Hongjie
- Nature Biomedical Engineering, Vol. 1, Issue 1
Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy
journal, April 2015
- Hong, Guosong; Diao, Shuo; Antaris, Alexander L.
- Chemical Reviews, Vol. 115, Issue 19
In Vivo Fluorescence Imaging with Ag 2 S Quantum Dots in the Second Near-Infrared Region
journal, September 2012
- Hong, Guosong; Robinson, Joshua T.; Zhang, Yejun
- Angewandte Chemie International Edition, Vol. 51, Issue 39
Bright, Stable, and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near-Infrared Spectral Region
journal, January 2017
- Lei, Zuhai; Li, Xinran; Luo, Xiao
- Angewandte Chemie International Edition, Vol. 56, Issue 11
Mesoporous silica nanoparticles for 19 F magnetic resonance imaging, fluorescence imaging, and drug delivery
journal, January 2015
- Nakamura, Tatsuya; Sugihara, Fuminori; Matsushita, Hisashi
- Chemical Science, Vol. 6, Issue 3
Whole-body imaging with fluorescent proteins
journal, August 2006
- Hoffman, Robert M.; Yang, Meng
- Nature Protocols, Vol. 1, Issue 3
Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window
journal, June 2014
- Hong, Guosong; Zou, Yingping; Antaris, Alexander L.
- Nature Communications, Vol. 5, Issue 1
In Vivo Fluorescence Imaging with Ag 2 S Quantum Dots in the Second Near-Infrared Region
journal, September 2012
- Hong, Guosong; Robinson, Joshua T.; Zhang, Yejun
- Angewandte Chemie, Vol. 124, Issue 39
Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes
journal, March 2015
- Sun, Yao; Ma, Xiaowei; Cheng, Kai
- Angewandte Chemie, Vol. 127, Issue 20
Flavylium Polymethine Fluorophores for Near- and Shortwave Infrared Imaging
journal, September 2017
- Cosco, Emily D.; Caram, Justin R.; Bruns, Oliver T.
- Angewandte Chemie, Vol. 129, Issue 42
Works referencing / citing this record:
NIR-II Fluorescence Imaging of Skin Avulsion and Necrosis
journal, October 2019
- Li, Yizhou; Hu, Xiang; Yi, Wanrong
- Frontiers in Chemistry, Vol. 7
Comparative study of two near-infrared coumarin–BODIPY dyes for bioimaging and photothermal therapy of cancer
journal, January 2019
- Zhang, Yuandong; Song, Nan; Li, Yuanyuan
- Journal of Materials Chemistry B, Vol. 7, Issue 30
Comparative study of two near-infrared coumarin–BODIPY dyes for bioimaging and photothermal therapy of cancer
journal, January 2019
- Zhang, Yuandong; Song, Nan; Li, Yuanyuan
- Journal of Materials Chemistry B, Vol. 7, Issue 30
NIR-II Fluorescence Imaging of Skin Avulsion and Necrosis
journal, October 2019
- Li, Yizhou; Hu, Xiang; Yi, Wanrong
- Frontiers in Chemistry, Vol. 7
Near-Infrared II Dye-Protein Complex for Biomedical Imaging and Imaging-Guided Photothermal Therapy
journal, July 2018
- Zeng, Xiaodong; Xiao, Yuling; Lin, Jiacheng
- Advanced Healthcare Materials, Vol. 7, Issue 18
Beyond 1000 nm Emission Wavelength: Recent Advances in Organic and Inorganic Emitters for Deep‐Tissue Molecular Imaging
journal, April 2019
- Ding, Feng; Fan, Yong; Sun, Yao
- Advanced Healthcare Materials, Vol. 8, Issue 14
Specific Small‐Molecule NIR‐II Fluorescence Imaging of Osteosarcoma and Lung Metastasis
journal, October 2019
- Zhou, Hui; Yi, Wanrong; Li, Anguo
- Advanced Healthcare Materials, Vol. 9, Issue 1
Improving Quantum Yield of a NIR‐II Dye by Phenylazo Group
journal, January 2020
- Zhang, Ling'e; Liu, Changren; Zhou, Sensen
- Advanced Healthcare Materials, Vol. 9, Issue 4
Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy
journal, September 2019
- Wang, Cong; Fan, Wenpei; Zhang, Zijian
- Advanced Materials, Vol. 31, Issue 49
Enhancing Photoacoustic Intensity of Upconversion Nanoparticles by Photoswitchable Azobenzene‐Containing Polymers for Dual NIR‐II and Photoacoustic Imaging In Vivo
journal, April 2019
- He, Shuqing; Song, Jun; Liu, Jianfeng
- Advanced Optical Materials, Vol. 7, Issue 12
Quaternary Ammonium Salt Based NIR‐II Probes for In Vivo Imaging
journal, May 2019
- Qu, Chunrong; Xiao, Yuling; Zhou, Hui
- Advanced Optical Materials, Vol. 7, Issue 15
Advanced NIR‐II Fluorescence Imaging Technology for In Vivo Precision Tumor Theranostics
journal, May 2019
- Li, Chunyan; Wang, Qiangbin
- Advanced Therapeutics, Vol. 2, Issue 9
Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging
journal, September 2019
- Zhang, Qing; Zhou, Huijun; Chen, Hao
- Small, Vol. 15, Issue 45
A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening−closing reaction strategy
journal, March 2019
- Sun, Yao; Chen, Sen; Chen, Xiaoya
- Nature Communications, Vol. 10, Issue 1
Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics
journal, May 2019
- Gao, Shuai; Wei, Guoguang; Zhang, Sihang
- Nature Communications, Vol. 10, Issue 1
First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows
journal, December 2019
- Hu, Zhenhua; Fang, Cheng; Li, Bo
- Nature Biomedical Engineering, Vol. 4, Issue 3
A NIR-II fluorescent probe for articular cartilage degeneration imaging and osteoarthritis detection
journal, January 2019
- Yi, Wanrong; Zhou, Hui; Li, Anguo
- Biomaterials Science, Vol. 7, Issue 3
A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection
journal, January 2019
- Zeng, Xiaodong; Chen, Ziyang; Tang, Lin
- Chemical Communications, Vol. 55, Issue 17
Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics
journal, January 2018
- He, Shuqing; Song, Jun; Qu, Junle
- Chemical Society Reviews, Vol. 47, Issue 12
Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
journal, January 2018
- Ding, Feng; Zhan, Yibei; Lu, Xiaoju
- Chemical Science, Vol. 9, Issue 19
Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging
journal, January 2019
- Lin, Jiacheng; Zeng, Xiaodong; Xiao, Yuling
- Chemical Science, Vol. 10, Issue 4
A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery
journal, January 2019
- Zeng, Xiaodong; Xie, Liru; Chen, Deliang
- Chemical Communications, Vol. 55, Issue 95
Recent progress in the imaging detection of enzyme activities in vivo
journal, January 2019
- Yang, Chunjie; Wang, Qian; Ding, Wu
- RSC Advances, Vol. 9, Issue 44
A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum( ii ) metallacycle for efficient cancer imaging and therapy
journal, January 2019
- Ding, Feng; Chen, Zhao; Kim, Won Young
- Chemical Science, Vol. 10, Issue 29
Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
journal, January 2019
- Zhang, Ruiping; Xu, Yuling; Zhang, Yi
- Chemical Science, Vol. 10, Issue 36
In situ generated chromophore as the indicator for background-free sensing strategy of hydrazine with high sensitivity with in vitro and in vivo applications
journal, January 2019
- Zhang, Peng; Gong, Yan; Zhang, Qian
- Journal of Materials Chemistry B, Vol. 7, Issue 34
Deciphering of cerebrovasculatures via ICG-assisted NIR-II fluorescence microscopy
journal, January 2019
- Yu, Xiaoming; Feng, Zhe; Cai, Zhaochong
- Journal of Materials Chemistry B, Vol. 7, Issue 42
Mn-Loaded apolactoferrin dots for in vivo MRI and NIR-II cancer imaging
journal, January 2019
- Zhou, Hui; Yang, Han; Tang, Lin
- Journal of Materials Chemistry C, Vol. 7, Issue 31
Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy
journal, January 2019
- Sun, Yue; Ding, Feng; Zhou, Zhixuan
- Proceedings of the National Academy of Sciences, Vol. 116, Issue 6
Critical Review—Recent Progress in NIR Fluorophores Emitting over 1000 nm for Bioimaging
journal, January 2019
- Jin, Takashi
- ECS Journal of Solid State Science and Technology, Vol. 8, Issue 1
Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.