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Title: Decoding Signal Processing at the Single-Cell Level

Abstract

The ability of cells to detect and decode information about their extracellular environment is critical to generating an appropriate response. In multicellular organisms, cells must decode dozens of signals from their neighbors and extracellular matrix to maintain tissue homeostasis while still responding to environmental stressors. How cells detect and process information from their surroundings through a surprisingly limited number of signal transduction pathways is one of the most important question in biology. Despite many decades of research, many of the fundamental principles that underlie cell signal processing remain obscure. However, in this issue of Cell Systems, Gillies et al present compelling evidence that the early response gene circuit can act as a linear signal integrator, thus providing significant insight into how cells handle fluctuating signals and noise in their environment.

Authors:
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1417444
Report Number(s):
PNNL-SA-131446
Journal ID: ISSN 2405-4712; 453040220
DOE Contract Number:
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cell Systems; Journal Volume: 5; Journal Issue: 6
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; EGFR; Systems Biology

Citation Formats

Wiley, H. Steven. Decoding Signal Processing at the Single-Cell Level. United States: N. p., 2017. Web. doi:10.1016/j.cels.2017.12.003.
Wiley, H. Steven. Decoding Signal Processing at the Single-Cell Level. United States. doi:10.1016/j.cels.2017.12.003.
Wiley, H. Steven. Fri . "Decoding Signal Processing at the Single-Cell Level". United States. doi:10.1016/j.cels.2017.12.003.
@article{osti_1417444,
title = {Decoding Signal Processing at the Single-Cell Level},
author = {Wiley, H. Steven},
abstractNote = {The ability of cells to detect and decode information about their extracellular environment is critical to generating an appropriate response. In multicellular organisms, cells must decode dozens of signals from their neighbors and extracellular matrix to maintain tissue homeostasis while still responding to environmental stressors. How cells detect and process information from their surroundings through a surprisingly limited number of signal transduction pathways is one of the most important question in biology. Despite many decades of research, many of the fundamental principles that underlie cell signal processing remain obscure. However, in this issue of Cell Systems, Gillies et al present compelling evidence that the early response gene circuit can act as a linear signal integrator, thus providing significant insight into how cells handle fluctuating signals and noise in their environment.},
doi = {10.1016/j.cels.2017.12.003},
journal = {Cell Systems},
number = 6,
volume = 5,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 2017},
month = {Fri Dec 01 00:00:00 EST 2017}
}