Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators
- Authors:
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1416584
- Resource Type:
- Journal Article: Publisher's Accepted Manuscript
- Journal Name:
- Bioorganic and Medicinal Chemistry Letters
- Additional Journal Information:
- Journal Name: Bioorganic and Medicinal Chemistry Letters Journal Volume: 27 Journal Issue: 12; Journal ID: ISSN 0960-894X
- Publisher:
- Elsevier
- Country of Publication:
- United Kingdom
- Language:
- English
Citation Formats
Cheruvallath, Zacharia S., Gwaltney, II, Stephen L., Sabat, Mark, Tang, Mingnam, Wang, Haixia, Jennings, Andy, Hosfield, David, Lee, Bumsup, Wu, Yiqin, Halkowycz, Petro, and Grimshaw, Charles E. Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators. United Kingdom: N. p., 2017.
Web. doi:10.1016/j.bmcl.2017.04.041.
Cheruvallath, Zacharia S., Gwaltney, II, Stephen L., Sabat, Mark, Tang, Mingnam, Wang, Haixia, Jennings, Andy, Hosfield, David, Lee, Bumsup, Wu, Yiqin, Halkowycz, Petro, & Grimshaw, Charles E. Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators. United Kingdom. https://doi.org/10.1016/j.bmcl.2017.04.041
Cheruvallath, Zacharia S., Gwaltney, II, Stephen L., Sabat, Mark, Tang, Mingnam, Wang, Haixia, Jennings, Andy, Hosfield, David, Lee, Bumsup, Wu, Yiqin, Halkowycz, Petro, and Grimshaw, Charles E. 2017.
"Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators". United Kingdom. https://doi.org/10.1016/j.bmcl.2017.04.041.
@article{osti_1416584,
title = {Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators},
author = {Cheruvallath, Zacharia S. and Gwaltney, II, Stephen L. and Sabat, Mark and Tang, Mingnam and Wang, Haixia and Jennings, Andy and Hosfield, David and Lee, Bumsup and Wu, Yiqin and Halkowycz, Petro and Grimshaw, Charles E.},
abstractNote = {},
doi = {10.1016/j.bmcl.2017.04.041},
url = {https://www.osti.gov/biblio/1416584},
journal = {Bioorganic and Medicinal Chemistry Letters},
issn = {0960-894X},
number = 12,
volume = 27,
place = {United Kingdom},
year = {Thu Jun 01 00:00:00 EDT 2017},
month = {Thu Jun 01 00:00:00 EDT 2017}
}
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Publisher's Version of Record at https://doi.org/10.1016/j.bmcl.2017.04.041
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Cited by: 16 works
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Works referenced in this record:
Type 2 diabetes market
journal, May 2005
- Gershell, Leland
- Nature Reviews Drug Discovery, Vol. 4, Issue 5
Drugs, QT Interval Prolongation and ICH E14: The Need to Get it Right
journal, January 2005
- Shah, Rashmi R.
- Drug Safety, Vol. 28, Issue 2
Initial Management of Glycemia in Type 2 Diabetes Mellitus
journal, October 2002
- Nathan, David M.
- New England Journal of Medicine, Vol. 347, Issue 17
Insulin sensitisation in the treatment of Type 2 diabetes
journal, March 2003
- Tadayyon, M.; Smith, Sa
- Expert Opinion on Investigational Drugs, Vol. 12, Issue 3
Design, synthesis and SAR of novel glucokinase activators
journal, April 2013
- Cheruvallath, Zacharia S.; Gwaltney, Stephen L.; Sabat, Mark
- Bioorganic & Medicinal Chemistry Letters, Vol. 23, Issue 7
Glucokinase Activators for Diabetes Therapy: May 2010 status report
journal, April 2011
- Matschinsky, F. M.; Zelent, B.; Doliba, N.
- Diabetes Care, Vol. 34, Issue Supplement_2
Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes MellitusProgressive Requirement for Multiple Therapies (UKPDS 49)
journal, June 1999
- Turner, Robert C.
- JAMA, Vol. 281, Issue 21
Insights into the Structure and Regulation of Glucokinase from a Novel Mutation (V62M), Which Causes Maturity-onset Diabetes of the Young
journal, April 2005
- Gloyn, Anna L.; Odili, Stella; Zelent, Dorothy
- Journal of Biological Chemistry, Vol. 280, Issue 14
A Comparison of Agents Used to Manage Type 2 Diabetes Mellitus: Need for Reappraisal of Traditional Approaches
journal, January 2004
- Bell, David S. H.
- Treatments in Endocrinology, Vol. 3, Issue 2
Small molecule glucokinase activators as novel anti-diabetic agents
journal, April 2005
- Leighton, B.; Atkinson, A.; Coghlan, M. P.
- Biochemical Society Transactions, Vol. 33, Issue 2
Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
journal, June 2009
- Pfefferkorn, Jeffrey A.; Lou, Jihong; Minich, Martha L.
- Bioorganic & Medicinal Chemistry Letters, Vol. 19, Issue 12
Glucokinase and glucose homeostasis: proven concepts and new ideas
journal, February 2005
- Zelent, D.; Najafi, H.; Odili, S.
- Biochemical Society Transactions, Vol. 33, Issue 1
Regulation of Pancreatic -Cell Glucokinase: From Basics to Therapeutics
journal, December 2002
- Matschinsky, F. M.
- Diabetes, Vol. 51, Issue Supplement 3
Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis
journal, February 2012
- Cumming, John G.; Tucker, Howard; Oldfield, John
- Bioorganic & Medicinal Chemistry Letters, Vol. 22, Issue 4