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Title: Mosaic HIV envelope immunogenic polypeptides

Abstract

Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.

Inventors:
; ; ; ;
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1415621
Patent Number(s):
9,855,329
Application Number:
15/025,806
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM); Dana-Farber Cancer Institute (Brookline, MA); Duke University (Durham, NC) LANL
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2016 Apr 02
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Korber, Bette T. M., Gnanakaran, S., Perkins, Simon, Sodroski, Joseph, and Haynes, Barton. Mosaic HIV envelope immunogenic polypeptides. United States: N. p., 2018. Web.
Korber, Bette T. M., Gnanakaran, S., Perkins, Simon, Sodroski, Joseph, & Haynes, Barton. Mosaic HIV envelope immunogenic polypeptides. United States.
Korber, Bette T. M., Gnanakaran, S., Perkins, Simon, Sodroski, Joseph, and Haynes, Barton. Tue . "Mosaic HIV envelope immunogenic polypeptides". United States. doi:. https://www.osti.gov/servlets/purl/1415621.
@article{osti_1415621,
title = {Mosaic HIV envelope immunogenic polypeptides},
author = {Korber, Bette T. M. and Gnanakaran, S. and Perkins, Simon and Sodroski, Joseph and Haynes, Barton},
abstractNote = {Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are sets of the disclosed mosaic Env polypeptides, which include two or more (for example, three) of the polypeptides. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject infected with HIV or at risk of HIV infection. In some embodiments, the methods include inducing an immune response to HIV in a subject comprising administering to the subject at least one (such as two, three, or more) of the immunogenic polypeptides or at least one (such as two, three, or more) nucleic acids encoding at least one of the immunogenic polypeptides disclosed herein.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 02 00:00:00 EST 2018},
month = {Tue Jan 02 00:00:00 EST 2018}
}

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