Producing alpha-olefins using polyketide synthases

Fortman, Jeffrey L.; Katz, Leonard; Steen, Eric J.; Keasling, Jay D.

Title: Producing alpha-olefins using polyketide synthases

Patent · Tue Jan 02 00:00:00 EST 2018

OSTI ID:1415467

Fortman, Jeffrey L.; Katz, Leonard; Steen, Eric J.; Keasling, Jay D.

The present invention provides for a polyketide synthase (PKS) capable of synthesizing an .alpha.-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the .alpha.-olefin.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 9,856,461

Application Number:: 14/853,821

OSTI ID:: 1415467

Resource Relation:: Patent File Date: 2015 Sep 14

Country of Publication:: United States

Language:: English

References (13)

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Production of Polyketides Arslanian, Robert L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070281343 US Patent Application 11/200525; 20070281343	patent-application	December 2007
3-Hydroxypropionic Acid And Other Organic Compounds Gokarn, Ravi R.; Selfifonova, Olga V.; Jessen, Holly Jean https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080076167 US Patent Application 11/942669; 20080076167	patent-application	March 2008
Production of Polyketides Julien, Bryan; Katz, Leonard; Khosla, Chaitan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090111151 US Patent Application 11/933002; 20090111151	patent-application	April 2009
Biosynthesis Of 1-Alkenes In Engineered Microorganisms Ridley, Christian Perry; Reppas, Nikos Basil https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100330642 US Patent Application 12/821107; 20100330642	patent-application	December 2010
Method For Enzymatic Production Of Decarboxylated Polyketides And Fatty Acids Sherman, David H.; Smith, Janet L.; Gu, Liangcai https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110091952 US Patent Application 12/842549; 20110091952	patent-application	April 2011
Engineering of modular polyketide synthases to produce novel polyketides Carreras, Christopher W.; Santi, Daniel V. Current Opinion in Biotechnology, Vol. 9, Issue 4, p. 403-411 https://doi.org/10.1016/S0958-1669(98)80015-3	journal	August 1998
Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula Chang, Zunxue; Sitachitta, Namthip; Rossi, James V. Journal of Natural Products, Vol. 67, Issue 8, p. 1356-1367 https://doi.org/10.1021/np0499261	journal	August 2004
Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412 Choi, Si-Sun; Kim, Eung-Soo Journal of Biotechnology, Vol. 136, S57 https://doi.org/10.1016/j.jbiotec.2008.07.123	journal	October 2008
Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase Erb, T. J.; Brecht, V.; Fuchs, G. Proceedings of the National Academy of Sciences, Vol. 106, Issue 22, p. 8871-8876 https://doi.org/10.1073/pnas.0903939106	journal	May 2009
Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis Gu, Liangcai; Wang, Bo; Kulkarni, Amol Journal of the American Chemical Society, Vol. 131, Issue 44, p. 16033-16035 https://doi.org/10.1021/ja9071578	journal	November 2009
Biosynthetic engineering of polyketide synthases Wilkinson, Barrie; Kendrew, Steven G.; Sheridan, Rose M. Expert Opinion on Therapeutic Patents, Vol. 13, Issue 10, p. 1579-1606 https://doi.org/10.1517/13543776.13.10.1579	journal	October 2003
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis Zhang, J.; Van Lanen, S. G.; Ju, J. Proceedings of the National Academy of Sciences, Vol. 105, Issue 5, p. 1460-1465 https://doi.org/10.1073/pnas.0711625105	journal	January 2008

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