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Title: Producing alpha-olefins using polyketide synthases

Abstract

The present invention provides for a polyketide synthase (PKS) capable of synthesizing an .alpha.-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the .alpha.-olefin.

Inventors:
; ; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1415467
Patent Number(s):
9,856,461
Application Number:
14/853,821
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Sep 14
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Fortman, Jeffrey L., Katz, Leonard, Steen, Eric J., and Keasling, Jay D. Producing alpha-olefins using polyketide synthases. United States: N. p., 2018. Web.
Fortman, Jeffrey L., Katz, Leonard, Steen, Eric J., & Keasling, Jay D. Producing alpha-olefins using polyketide synthases. United States.
Fortman, Jeffrey L., Katz, Leonard, Steen, Eric J., and Keasling, Jay D. Tue . "Producing alpha-olefins using polyketide synthases". United States. doi:. https://www.osti.gov/servlets/purl/1415467.
@article{osti_1415467,
title = {Producing alpha-olefins using polyketide synthases},
author = {Fortman, Jeffrey L. and Katz, Leonard and Steen, Eric J. and Keasling, Jay D.},
abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing an .alpha.-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the .alpha.-olefin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 02 00:00:00 EST 2018},
month = {Tue Jan 02 00:00:00 EST 2018}
}

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Works referenced in this record:

Engineering of modular polyketide synthases to produce novel polyketides
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Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase
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