Amplification of biological targets via on-chip culture for biosensing

Harper, Jason C.; Edwards, Thayne L.; Carson, Bryan; Finley, Melissa; Arndt, William

Title: Amplification of biological targets via on-chip culture for biosensing

Patent · Tue Jan 02 00:00:00 EST 2018

OSTI ID:1415449

Harper, Jason C.; Edwards, Thayne L.; Carson, Bryan; Finley, Melissa; Arndt, William

The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

View Patent

Cite

Export

Save

Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)

Patent Number(s):: 9,857,370

Application Number:: 14/157,378

OSTI ID:: 1415449

Resource Relation:: Patent File Date: 2014 Jan 16

Country of Publication:: United States

Language:: English

References (28)

Stabilization of Peracid Solutions Reichert, Joseph S.; McNeight, Samuel A.; Elston, Arthur A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/2347434 US Patent Document 2,347,434	patent	April 1944
Stabilization of Dilute Solutions of Aliphatic Acids Greenspan, Frank P.; MacKellar, Donald G. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/2590856 US Patent Document 2,590,856	patent	April 1952
Stabilization of Peracids with Dipicolinic Acid Greenspan, Frank P.; MacKellar, Donald G. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/2609391 US Patent Document 2,609,391	patent	September 1952
Stable peroxy-containing microbicides Bowing, Walter Grosse; Mrozek, Hinrich; Schlussler, Hans-Joachim https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4051058 US Patent Document 4,051,058	patent	September 1977
Stable, shippable, peroxy-containing microbicide Cosentino, Louis C.; Hnojewyj, Anatol M.; Fischbach, LeRoy J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5656302 US Patent Document 5,656,302	patent	August 1997
Fluorogenic compounds Bentsen, James G.; Mickelson, Christopher Allen; Knudson, Orlin B. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6372895 US Patent Document 6,372,895	patent	April 2002
Fluorogenic compounds and uses therefor Bentsen, James G.; Mickelson, Christopher Allen; Knudson, Orlin B. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6566508 US Patent Document 6,566,508	patent	May 2003
Microwell cell-culture device and fabrication method Hung, Paul J.; Lee, Philip J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8257964 US Patent Document 8,257,964	patent	September 2012
Methods for the detection, analysis and isolation of nascent proteins Rothschild, Kenneth J.; Gite, Sadanand; Olejnik, Jerzy https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8278045 US Patent Document 8,278,045	patent	October 2012
Methods and apparatus for pathogen detection and analysis Mathies, Richard A.; Grover;, William H.; Paegel, Brian https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060073484 US Patent Application 10/540658; 20060073484	patent-application	April 2006
Arrays, Substrates, Devices, Methods And Systems For Detecting Target Molecules Fan, Rong; Ahmad, Habib; Heath, James R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090036324 US Patent Application 12/174601; 20090036324	patent-application	February 2009
Microfluidic Devices, Methods And Systems For Detecting Target Molecules Vermesh, Ophir; Yen, Brian K.H.; Heath, James R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090053732 US Patent Application 12/174598; 20090053732	patent-application	February 2009
On-chip cell migration detection Wang, Lei; Zhu, Jing; Deng, Cheng https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090251155 US Patent Application 12/288971; 20090251155	patent-application	October 2009
Thin Film Chemical Analysis Apparatus And Analysis Method Using The Same Yoo, Jae-chern https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090317896 US Patent Application 12/376034; 20090317896	patent-application	December 2009
Dilute Aqueous Peracid Solutions and Stabilization Method Dada, Emmanuel A.; Lapham, III, Donald S. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100021558 US Patent Application 12/507484; 20100021558	patent-application	January 2010
Thin Film Valve Device And Its Controlling Apparatus Yoo, Jae Chern https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100243078 US Patent Application 12/743933; 20100243078	patent-application	September 2010
Thin Film Bio Valve Device And Its Controlling Apparatus Yoo, Jae Chern https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100288949 US Patent Application 12/747117; 20100288949	patent-application	November 2010
Microfluidic Platform For Cell Culture And Assay Tseng, Hsian-Rong; Yu, Tak For; Guo, Shuling https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110129850 US Patent Application 12/520376; 20110129850	patent-application	June 2011
Methods For The Detection, Analysis And Isolation Of Nascent Proteins Rothschild, Kenneth J.; Gite, Sadanand; Olejnik, Jerzy https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110250609 US Patent Application 13/023725; 20110250609	patent-application	October 2011
Devices and Methods for Pharmacokinetic-Based Cell Culture System Shuler, Michael; Baxter, Gregory T.; Sin, Aaron https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120214189 US Patent Application 13/301261; 20120214189	patent-application	August 2012
Microfluidic Chip for High-Throughput Perfusion-Based Three-Dimensional Cell Culture Wu, Min-Hsien; Wang, Shih-Siou; Tsai, Wan-Chen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120231976 US Patent Application 13/241123; 20120231976	patent-application	September 2012
Biodetection Methods and Compositions Church, George M.; Adesokan, Adeyemi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130224729 US Patent Application 13/389839; 20130224729	patent-application	August 2013
Point-of-care nucleic acid testing for infectious diseases Niemz, Angelika; Ferguson, Tanya M.; Boyle, David S. Trends in Biotechnology, Vol. 29, Issue 5, p. 240-250 https://doi.org/10.1016/j.tibtech.2011.01.007	journal	May 2011
Laser Machined Plastic Laminates: Towards Portable Diagnostic Devices for Use in Low Resource Environments Harper, Jason C.; Carson, Bryan D.; Bachand, George D. Electroanalysis, Vol. 27, Issue 11, p. 2503-2512 https://doi.org/10.1002/elan.201500359	journal	July 2015
Magnetic-adhesive based valves for microfluidic devices used in low-resource settings Harper, Jason C.; Andrews, Jenna M.; Ben, Candice Lab on a Chip, Vol. 16, Issue 21, p. 4142-4151 https://doi.org/10.1039/C6LC00858E	journal	January 2016
Selective Immobilization of DNA and Antibody Probes on Electrode Arrays: Simultaneous Electrochemical Detection of DNA and Protein on a Single Platform Harper, Jason C.; Polsky, Ronen; Wheeler, David R. Langmuir, Vol. 23, Issue 16, p. 8285-8287 https://doi.org/10.1021/la701775g	journal	July 2007
Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications Polsky, Ronen; Harper, Jason C.; Wheeler, David R. Biosensors and Bioelectronics, Vol. 23, Issue 6, p. 757-764 https://doi.org/10.1016/j.bios.2007.08.013	journal	January 2008
Reagentless electrochemical immunoassay using electrocatalytic nanoparticle-modified antibodies Polsky, Ronen; Harper, Jason C.; Wheeler, David R. Chemical Communications, Vol. 0, Issue 26, p. 2741-2743 https://doi.org/10.1039/B704012A	journal	January 2007

Similar Records

Amplification of biological targets via on-chip culture for biosensing

Patent · Tue Nov 13 00:00:00 EST 2018 · OSTI ID:1415449

Harper, Jason C.; Edwards, Thayne L.; Carson, Bryan; +2 more

Apparatus comprising magnetically actuated valves and uses thereof

Patent · Tue Jul 12 00:00:00 EDT 2016 · OSTI ID:1415449

Edwards, Thayne L.; Harper, Jason C.

Microsystem strategies for sample preparation in biological detection.

Technical Report · Tue Mar 01 00:00:00 EST 2005 · OSTI ID:1415449

James, Conrad D; Galambos, Paul C; Bennett, Dawn Jonita; +5 more

Related Subjects

47 OTHER INSTRUMENTATION
59 BASIC BIOLOGICAL SCIENCES

Title: Amplification of biological targets via on-chip culture for biosensing

Citation Formats

References (28)

Similar Records

Related Subjects