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Title: Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh

Abstract

Ruthenium-103 is the parent isotope of 103mRh (t1/2 56.1 min), an isotope of interest for Auger electron therapy. During the proton irradiation of thorium targets, large amounts of 103Ru are generated through proton induced fission. Furthermore, the development of a two part chemical separation process to isolate 103Ru in high yield and purity from a proton irradiated thorium matrix on an analytical scale is described herein. The first part employed an anion exchange column to remove cationic actinide/lanthanide impurities along with the majority of the transition metal fission products. Secondly, an extraction chromatographic column utilizing diglycolamide functional groups was used to decontaminate 103Ru from the remaining impurities. This method then resulted in a final radiochemical yield of 83 ± 5% of 103Ru with a purity of 99.9%. Additionally, measured nuclear reaction cross sections for the formation of 103Ru and 106Ru via the 232Th(p,f) 103,106Ru reactions are reported within.

Authors:
ORCiD logo [1];  [1];  [1];  [1];  [1];  [2];  [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1];  [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
OSTI Identifier:
1414632
Alternate Identifier(s):
OSTI ID: 1416310
Report Number(s):
LA-UR-17-29067
Journal ID: ISSN 1932-6203
Grant/Contract Number:
AC52-06NA25396; LDRD 20160439ER
Resource Type:
Journal Article: Published Article
Journal Name:
PLoS ONE
Additional Journal Information:
Journal Volume: 12; Journal Issue: 12; Journal ID: ISSN 1932-6203
Publisher:
Public Library of Science
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY

Citation Formats

Mastren, Tara, Radchenko, Valery, Hopkins, Philip D., Engle, Jonathan W., Weidner, John W., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., Fassbender, Michael Ernst-Heinrich, and Merk, Bruno. Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh. United States: N. p., 2017. Web. doi:10.1371/journal.pone.0190308.
Mastren, Tara, Radchenko, Valery, Hopkins, Philip D., Engle, Jonathan W., Weidner, John W., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., Fassbender, Michael Ernst-Heinrich, & Merk, Bruno. Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh. United States. doi:10.1371/journal.pone.0190308.
Mastren, Tara, Radchenko, Valery, Hopkins, Philip D., Engle, Jonathan W., Weidner, John W., Copping, Roy, Brugh, Mark, Nortier, F. Meiring, Birnbaum, Eva R., John, Kevin D., Fassbender, Michael Ernst-Heinrich, and Merk, Bruno. Fri . "Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh". United States. doi:10.1371/journal.pone.0190308.
@article{osti_1414632,
title = {Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh},
author = {Mastren, Tara and Radchenko, Valery and Hopkins, Philip D. and Engle, Jonathan W. and Weidner, John W. and Copping, Roy and Brugh, Mark and Nortier, F. Meiring and Birnbaum, Eva R. and John, Kevin D. and Fassbender, Michael Ernst-Heinrich and Merk, Bruno},
abstractNote = {Ruthenium-103 is the parent isotope of 103mRh (t1/2 56.1 min), an isotope of interest for Auger electron therapy. During the proton irradiation of thorium targets, large amounts of 103Ru are generated through proton induced fission. Furthermore, the development of a two part chemical separation process to isolate 103Ru in high yield and purity from a proton irradiated thorium matrix on an analytical scale is described herein. The first part employed an anion exchange column to remove cationic actinide/lanthanide impurities along with the majority of the transition metal fission products. Secondly, an extraction chromatographic column utilizing diglycolamide functional groups was used to decontaminate 103Ru from the remaining impurities. This method then resulted in a final radiochemical yield of 83 ± 5% of 103Ru with a purity of 99.9%. Additionally, measured nuclear reaction cross sections for the formation of 103Ru and 106Ru via the 232Th(p,f)103,106Ru reactions are reported within.},
doi = {10.1371/journal.pone.0190308},
journal = {PLoS ONE},
number = 12,
volume = 12,
place = {United States},
year = {Fri Dec 22 00:00:00 EST 2017},
month = {Fri Dec 22 00:00:00 EST 2017}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1371/journal.pone.0190308

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