skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mathematical modeling of Zika disease in pregnant women and newborns with microcephaly in Brazil

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]; ORCiD logo [4]; ORCiD logo [4]
  1. African Institute for Mathematical Sciences, AIMS-Cameroon, P.O. Box 608 Limbé Crystal Gardens South West Region Cameroon, Departamento de Matemática Aplicada II, E.E. Aeronáutica e do Espazo, Universidade de Vigo, Campus As Lagoas s/n Ourense 32004 Spain
  2. Departamento de Matemática Aplicada II, E.E. Aeronáutica e do Espazo, Universidade de Vigo, Campus As Lagoas s/n Ourense 32004 Spain
  3. Instituto de Matemáticas, Universidade de Santiago de Compostela, Santiago de Compostela 15782 Spain
  4. Center for Research and Development in Mathematics and Applications (CIDMA), Department of Mathematics, University of Aveiro, Aveiro 3810-193 Portugal
Publication Date:
Sponsoring Org.:
USDOE Office of Nuclear Energy (NE), Fuel Cycle Technologies (NE-5)
OSTI Identifier:
1414488
Grant/Contract Number:
CIDMA UID/MAT/04106/2013; TOCCATA PTDC/EEI-AUT/2933/2014; SFRH/BPD/72061/2010
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Mathematical Methods in the Applied Sciences
Additional Journal Information:
Related Information: CHORUS Timestamp: 2017-12-21 08:18:08; Journal ID: ISSN 0170-4214
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
Germany
Language:
English

Citation Formats

Ndaïrou, Faïçal, Area, Iván, Nieto, Juan J., Silva, Cristiana J., and Torres, Delfim F. M. Mathematical modeling of Zika disease in pregnant women and newborns with microcephaly in Brazil. Germany: N. p., 2017. Web. doi:10.1002/mma.4702.
Ndaïrou, Faïçal, Area, Iván, Nieto, Juan J., Silva, Cristiana J., & Torres, Delfim F. M. Mathematical modeling of Zika disease in pregnant women and newborns with microcephaly in Brazil. Germany. doi:10.1002/mma.4702.
Ndaïrou, Faïçal, Area, Iván, Nieto, Juan J., Silva, Cristiana J., and Torres, Delfim F. M. Thu . "Mathematical modeling of Zika disease in pregnant women and newborns with microcephaly in Brazil". Germany. doi:10.1002/mma.4702.
@article{osti_1414488,
title = {Mathematical modeling of Zika disease in pregnant women and newborns with microcephaly in Brazil},
author = {Ndaïrou, Faïçal and Area, Iván and Nieto, Juan J. and Silva, Cristiana J. and Torres, Delfim F. M.},
abstractNote = {},
doi = {10.1002/mma.4702},
journal = {Mathematical Methods in the Applied Sciences},
number = ,
volume = ,
place = {Germany},
year = {Thu Dec 21 00:00:00 EST 2017},
month = {Thu Dec 21 00:00:00 EST 2017}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on December 21, 2018
Publisher's Accepted Manuscript

Save / Share:
  • Blood lead concentrations of a group of mothers and their newborns were studied. The results showed a correlation between maternal and newborn levels. It is suggested that biochemical alterations may be present in some of the mothers and in a smaller proportion of the newborns. In addition, a comparison of the lead levels in blood with those in the environment was made.
  • The risk of ubiquitous perchlorate exposure and the dose-response on thyroid hormone levels in pregnant women in the United States (U.S.) have yet to be characterized. In the current work, we integrated a previously developed perchlorate submodel into a recently developed population-based pregnancy model to predict reductions in maternal serum free thyroxine (fT4) levels for late-gestation pregnant women in the U.S. Our findings indicated no significant difference in geometric mean estimates of fT4 when perchlorate exposure from food only was compared to no perchlorate exposure. The reduction in maternal fT4 levels reached statistical significance when an added contribution from drinkingmore » water (i.e., 15 μg/L, 20 μg/L, or 24.5 μg/L) was assumed in addition to the 90th percentile of food intake for pregnant women (0.198 μg/kg/day). We determined that a daily intake of 0.45 to 0.50 μg/kg/day of perchlorate was necessary to produce results that were significantly different than those obtained from no perchlorate exposure. Adjusting for this food intake dose, the relative source contribution of perchlorate from drinking water (or other non-dietary sources) was estimated to range from 0.25–0.3 μg/kg/day. Assuming a drinking water intake rate of 0.033 L/kg/day, the drinking water concentration allowance for perchlorate equates to 7.6–9.2 μg/L. In summary, we have demonstrated the utility of a probabilistic biologically-based dose-response model for perchlorate risk assessment in a sensitive life-stage at a population level; however, there is a need for continued monitoring in regions of the U.S. where perchlorate exposure may be higher. - Highlights: • Probabilistic risk assessment for perchlorate in U.S. pregnant women was conducted. • No significant change in maternal fT4 predicted due to perchlorate from food alone. • Drinking water concentration allowance for perchlorate estimated as 7.6–9.2 μg/L.« less
  • Although an excess of human adult blood adherent cells inhibits the pokeweed mitogen- (PWM) induced normal adult lymphocyte proliferation and B cell maturation into immunoglobulin-containing cells (ICC), adherent cells collected from newborn infants or pregnant women at time of delivery were unable to exert a similar suppressor activity. After activation by Concanavalin A (Con A), newborns' and pregnant women's adherent cells acquired a suppressor activity comparable to that of control adult adherent cells. The adherent suppressor cell was shown to be radioresistant (3000 rad), indicating its probable monocytic orgin. Both monocyte-suppressor activities (MSA) observed in adulthood (spontaneously) and in themore » neonatal period (after activation) were dependent on prostaglandin E/sub 2/ (PGE/sub 2/) secretion, because they were abolished by indomethacin or a specific anti-PGE/sub 2/ anti-serum. Expression of MSA appeared to be under a negative regulation exerted by naturally occurring T suppressor lymphocytes present in the blood of newborns or pregnant women, because incubation of adult monocytes or Con A-activated newborn monocytes with newborns' or pregnant women's T lymphocytes resulted in a dramatic decrease of their MSA. These results strongly suggest that the lack of MSA in the neonatal period and in late pregnancy is a consequence of activation of T suppressor lymphocytes.« less
  • Newborn and maternal hair samples were obtained from subjects occupationally exposed to heavy metals and from matched controls. The geometric means of levels of cadmium and lead in hair from exposed mothers and cadmium in hair from transplacentally exposed newborns were twice as high as levels present in samples from controls. There was a positive correlation between levels of cadmium in maternal and newborn's hair, but no such correlation for lead. Despite statistically significant evidence of increased exposure to cadmium, no adverse health effects were documented in the small group of exposed newborns included in this study. Problems associated withmore » exogenous contamination of hair by heavy metals and potential advantages of hair sampling for measuring fetal exposures to heavy metals are discussed.« less