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Title: Metabolizing Data in the Cloud

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USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
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Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Trends in Biotechnology
Additional Journal Information:
Journal Volume: 35; Journal Issue: 6; Related Information: CHORUS Timestamp: 2017-12-18 08:26:59; Journal ID: ISSN 0167-7799
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Citation Formats

Warth, Benedikt, Levin, Nadine, Rinehart, Duane, Teijaro, John, Benton, H. Paul, and Siuzdak, Gary. Metabolizing Data in the Cloud. Netherlands: N. p., 2017. Web. doi:10.1016/j.tibtech.2016.12.010.
Warth, Benedikt, Levin, Nadine, Rinehart, Duane, Teijaro, John, Benton, H. Paul, & Siuzdak, Gary. Metabolizing Data in the Cloud. Netherlands. doi:10.1016/j.tibtech.2016.12.010.
Warth, Benedikt, Levin, Nadine, Rinehart, Duane, Teijaro, John, Benton, H. Paul, and Siuzdak, Gary. 2017. "Metabolizing Data in the Cloud". Netherlands. doi:10.1016/j.tibtech.2016.12.010.
title = {Metabolizing Data in the Cloud},
author = {Warth, Benedikt and Levin, Nadine and Rinehart, Duane and Teijaro, John and Benton, H. Paul and Siuzdak, Gary},
abstractNote = {},
doi = {10.1016/j.tibtech.2016.12.010},
journal = {Trends in Biotechnology},
number = 6,
volume = 35,
place = {Netherlands},
year = 2017,
month = 6

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on May 17, 2018
Publisher's Accepted Manuscript

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Cited by: 3works
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  • Five established hepatoma cell lines, 1 of rat origin and 4 derived from human liver carcinoma, were compared for their capacity to perform metabolic activation of one polycyclic hydrocarbon, benzo(a)pyrene (BP), and one cyclodiene chlorinated insecticide, aldrin. The results of these investigations indicated both species and individual differences among these cell lines. Aldrin was found to be converted into dieldrin much more efficiently by the rat hepatoma cell line than by any human cell lines, whereas 2 human lines displayed the highest BP-metabolizing activity whether measured as the amounts of water-soluble products or estimated by cytotoxic cell-mediated assays. Results alsomore » showed that one particular human cell line can replace, advantageously, V79 hamster cells as target in a cell-mediated assay owing to its incapability to metabolize BP and its high sensitivity to BP metabolites.« less
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