Gold core/Ceria shell-based redox active nanozyme mimicking the biological multienzyme complex phenomenon

Bhagat, Stuti; Srikanth Vallabani, NV; Shutthanandan, Vaithiyalingam; Bowden, Mark; Karakoti, Ajay S.; Singh, Sanjay

doi:10.1016/J.JCIS.2017.11.064

Title: Gold core/Ceria shell-based redox active nanozyme mimicking the biological multienzyme complex phenomenon

Journal Article · Sat Dec 02 00:00:00 EST 2017 · Journal of Colloid and Interface Science

DOI:https://doi.org/10.1016/J.JCIS.2017.11.064· OSTI ID:1413465

Bhagat, Stuti ^[1]; Srikanth Vallabani, NV ^[1]; Shutthanandan, Vaithiyalingam ^[2]; Bowden, Mark ^[2]; Karakoti, Ajay S. ^[3]; Singh, Sanjay ^[1]

Ahmedabad Univ., Gujarat (India). School of Arts and Sciences
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab.
Ahmedabad Univ., Gujarat (India). School of Arts and Sciences, School of Engineering and Applied Science

Catalytically active individual gold (Au) and cerium oxide (CeO₂) nanoparticles (NPs) are well known to exhibit specific enzyme-like activities, such as natural catalase, oxidase, superoxide dismutase, and peroxidase enzymes. Our activities have been maneuvered to design several biological applications such as immunoassays, glucose detection, radiation and free radical protection and tissue engineering. In biological systems, multienzyme complexes are involved in catalyzing important reactions of essential metabolic processes such as respiration, biomolecule synthesis, and photosynthesis. It is well known that metabolic processes linked with multienzyme complexes offer several advantages over reactions catalyzed by individual enzymes. A functional nanozyme depicting multienzyme like properties has eluded the researchers in the nanoscience community for the past few decades. Here, we have designed a functional multienzyme in the form of Gold (core)-CeO₂ (shell) nanoparticles (Au/CeO₂ CSNPs) exhibiting excellent peroxidase, catalase, and superoxide dismutase enzyme-like activities that are controlled simply by tuning the pH. The reaction kinetic parameters reveal that the peroxidase-like activity of this core-shell nanozyme is comparable to natural horseradish peroxidase (HRP) enzyme. Unlike peroxidase-like activity exhibited by other nanomaterials, Au/CeO₂ CSNPs showed a decrease in hydroxyl radical formation, suggesting that the biocatalytic reactions are performed by efficient electron transfers. A significant enzyme-like activity of this core-shell nanoparticle was conserved at extreme pH (2 – 11) and temperatures (up to 90 °C), clearly suggesting the superiority over natural enzymes. Further, the utility of peroxidase-like activity of this core-shell nanoparticles was extended for the detection of glucose, which showed a linear range of detection between (100 µM – 1 mM). It is hypothesized that the proximity of the redox potentials of Au+/Au and Ce (III)/Ce (IV) may result in a redox couple promoting the multienzyme activity of core-shell nanoparticles. Au/CeO₂ CSNPs may open new directions for development of single platform sensors in multiple biosensing applications.

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Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1413465

Alternate ID(s):: OSTI ID: 1562764

Report Number(s):: PNNL-SA-128017; PII: S0021979717313693

Journal Information:: Journal of Colloid and Interface Science, Vol. 513; ISSN 0021-9797

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 74 works

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References (52)

Intrinsic peroxidase-like activity of ferromagnetic nanoparticles Gao, Lizeng; Zhuang, Jie; Nie, Leng Nature Nanotechnology, Vol. 2, Issue 9 https://doi.org/10.1038/nnano.2007.260	journal	August 2007
Hidden talent Perez, J. Manuel Nature Nanotechnology, Vol. 2, Issue 9 https://doi.org/10.1038/nnano.2007.282	journal	August 2007
Superparamagnetic Fe3O4 nanoparticles as catalysts for the catalytic oxidation of phenolic and aniline compounds Zhang, Shengxiao; Zhao, Xiaoli; Niu, Hongyun Journal of Hazardous Materials, Vol. 167, Issue 1-3 https://doi.org/10.1016/j.jhazmat.2009.01.024	journal	August 2009
Catalytically Active Nanomaterials: A Promising Candidate for Artificial Enzymes Lin, Youhui; Ren, Jinsong; Qu, Xiaogang Accounts of Chemical Research, Vol. 47, Issue 4 https://doi.org/10.1021/ar400250z	journal	January 2014
Cerium oxide based nanozymes: Redox phenomenon at biointerfaces Singh, Sanjay Biointerphases, Vol. 11, Issue 4 https://doi.org/10.1116/1.4966535	journal	December 2016
Redox-Sensitive Cerium Oxide Nanoparticles Protect Human Keratinocytes from Oxidative Stress Induced by Glutathione Depletion Singh, Ragini; Karakoti, Ajay S.; Self, William Langmuir, Vol. 32, Issue 46 https://doi.org/10.1021/acs.langmuir.6b03022	journal	November 2016
Synthesis of Tetrahexahedral Platinum Nanocrystals with High-Index Facets and High Electro-Oxidation Activity Tian, N.; Zhou, Z. -Y.; Sun, S. -G. Science, Vol. 316, Issue 5825, p. 732-735 https://doi.org/10.1126/science.1140484	journal	May 2007
Molecular Factors of Catalytic Selectivity Somorjai, Gabor A.; Park, Jeong Y. Angewandte Chemie International Edition, Vol. 47, Issue 48 https://doi.org/10.1002/anie.200803181	journal	November 2008
Nano-Gold as Artificial Enzymes: Hidden Talents Lin, Youhui; Ren, Jinsong; Qu, Xiaogang Advanced Materials, Vol. 26, Issue 25 https://doi.org/10.1002/adma.201400238	journal	April 2014
ATP-enhanced peroxidase-like activity of gold nanoparticles Shah, Juhi; Purohit, Rahul; Singh, Ragini Journal of Colloid and Interface Science, Vol. 456 https://doi.org/10.1016/j.jcis.2015.06.015	journal	October 2015
Redox-active radical scavenging nanomaterials Karakoti, Ajay; Singh, Sanjay; Dowding, Janet M. Chemical Society Reviews, Vol. 39, Issue 11 https://doi.org/10.1039/b919677n	journal	January 2010
PEGylated Nanoceria as Radical Scavenger with Tunable Redox Chemistry Karakoti, Ajay S.; Singh, Sanjay; Kumar, Amit Journal of the American Chemical Society, Vol. 131, Issue 40 https://doi.org/10.1021/ja9051087	journal	October 2009
Custom Cerium Oxide Nanoparticles Protect against a Free Radical Mediated Autoimmune Degenerative Disease in the Brain Heckman, Karin L.; DeCoteau, William; Estevez, Ana ACS Nano, Vol. 7, Issue 12 https://doi.org/10.1021/nn403743b	journal	November 2013
Nanoceria exhibit redox state-dependent catalase mimetic activity Pirmohamed, Talib; Dowding, Janet M.; Singh, Sanjay Chemical Communications, Vol. 46, Issue 16 https://doi.org/10.1039/b922024k	journal	January 2010
The role of cerium redox state in the SOD mimetic activity of nanoceria Heckert, Eric G.; Karakoti, Ajay S.; Seal, Sudipta Biomaterials, Vol. 29, Issue 18 https://doi.org/10.1016/j.biomaterials.2008.03.014	journal	June 2008
Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles Korsvik, Cassandra; Patil, Swanand; Seal, Sudipta Chemical Communications, Issue 10 https://doi.org/10.1039/b615134e	journal	January 2007
Catalytic properties and biomedical applications of cerium oxide nanoparticles Walkey, Carl; Das, Soumen; Seal, Sudipta Environmental Science: Nano, Vol. 2, Issue 1 https://doi.org/10.1039/C4EN00138A	journal	January 2015
A Multienzyme Complex Channels Substrates and Electrons through Acetyl-CoA and Methane Biosynthesis Pathways in Methanosarcina Lieber, Dillon J.; Catlett, Jennifer; Madayiputhiya, Nandu PLoS ONE, Vol. 9, Issue 9 https://doi.org/10.1371/journal.pone.0107563	journal	September 2014
Natural strategies for the spatial optimization of metabolism in synthetic biology Agapakis, Christina M.; Boyle, Patrick M.; Silver, Pamela A. Nature Chemical Biology, Vol. 8, Issue 6 https://doi.org/10.1038/nchembio.975	journal	May 2012
Complexes of Sequential Metabolic Enzymes Srere, Paul A. Annual Review of Biochemistry, Vol. 56, Issue 1 https://doi.org/10.1146/annurev.bi.56.070187.000513	journal	June 1987
Swinging Arms and Swinging Domains in Multifunctional Enzymes: Catalytic Machines for Multistep Reactions Perham, Richard N. Annual Review of Biochemistry, Vol. 69, Issue 1 https://doi.org/10.1146/annurev.biochem.69.1.961	journal	June 2000
Mesoporous silica-encapsulated gold nanoparticles as artificial enzymes for self-activated cascade catalysis Lin, Youhui; Li, Zhenhua; Chen, Zhaowei Biomaterials, Vol. 34, Issue 11 https://doi.org/10.1016/j.biomaterials.2013.01.007	journal	April 2013
In Situ Synthesis of Self-Assembled Three-Dimensional Graphene–Magnetic Palladium Nanohybrids with Dual-Enzyme Activity through One-Pot Strategy and Its Application in Glucose Probe Zheng, Xuejing; Zhu, Qian; Song, Huiqing ACS Applied Materials & Interfaces, Vol. 7, Issue 6 https://doi.org/10.1021/am508540x	journal	February 2015
Dual Enzyme-like Activities of Iron Oxide Nanoparticles and Their Implication for Diminishing Cytotoxicity Chen, Zhongwen; Yin, Jun-Jie; Zhou, Yu-Ting ACS Nano, Vol. 6, Issue 5 https://doi.org/10.1021/nn300291r	journal	May 2012
Nanotechnology in Disease Diagnostic Techniques Savaliya, Reema; Shah, Darshini; Singh, Ragini Current Drug Metabolism, Vol. 16, Issue 8 https://doi.org/10.2174/1389200216666150625121546	journal	November 2015
Pharmacological Drug Delivery Strategies for Improved Therapeutic Effects: Recent Advances Savaliya, Reema; Singh, Poornima; Singh, Sanjay Current Pharmaceutical Design, Vol. 22, Issue 11 https://doi.org/10.2174/1381612822666151210123546	journal	March 2016
A novel voltammetric sensor based on gold nanoparticles involved in p-aminothiophenol functionalized multi-walled carbon nanotubes: Application to the simultaneous determination of quercetin and rutin Yola, Mehmet Lütfi; Atar, Necip Electrochimica Acta, Vol. 119 https://doi.org/10.1016/j.electacta.2013.12.028	journal	February 2014
Catalytic reduction–adsorption for removal of p-nitrophenol and its conversion p-aminophenol from water by gold nanoparticles supported on oxidized mesoporous carbon Guo, Pucan; Tang, Lin; Tang, Jing Journal of Colloid and Interface Science, Vol. 469 https://doi.org/10.1016/j.jcis.2016.01.063	journal	May 2016
Sensitive and selective determination of aqueous triclosan based on gold nanoparticles on polyoxometalate/reduced graphene oxide nanohybrid Yola, Mehmet Lütfi; Atar, Necip; Eren, Tanju RSC Advances, Vol. 5, Issue 81 https://doi.org/10.1039/C5RA07443F	journal	January 2015
A novel determination of curcumin via Ru@Au nanoparticle decorated nitrogen and sulfur-functionalized reduced graphene oxide nanomaterials Kotan, Gül; Kardaş, Faruk; Yokuş, Özlem Aktaş Analytical Methods, Vol. 8, Issue 2 https://doi.org/10.1039/C5AY02950C	journal	January 2016
A sensitive molecular imprinted electrochemical sensor based on gold nanoparticles decorated graphene oxide: Application to selective determination of tyrosine in milk Yola, Mehmet Lütfi; Eren, Tanju; Atar, Necip Sensors and Actuators B: Chemical, Vol. 210 https://doi.org/10.1016/j.snb.2014.12.098	journal	April 2015
A novel and sensitive electrochemical DNA biosensor based on Fe@Au nanoparticles decorated graphene oxide Yola, Mehmet Lütfi; Eren, Tanju; Atar, Necip Electrochimica Acta, Vol. 125 https://doi.org/10.1016/j.electacta.2014.01.074	journal	April 2014
Molecularly imprinted electrochemical biosensor based on Fe@Au nanoparticles involved in 2-aminoethanethiol functionalized multi-walled carbon nanotubes for sensitive determination of cefexime in human plasma Yola, Mehmet Lütfi; Eren, Tanju; Atar, Necip Biosensors and Bioelectronics, Vol. 60 https://doi.org/10.1016/j.bios.2014.04.045	journal	October 2014
A novel magnetic Fe@Au core–shell nanoparticles anchored graphene oxide recyclable nanocatalyst for the reduction of nitrophenol compounds Gupta, Vinod Kumar; Atar, Necip; Yola, Mehmet Lütfi Water Research, Vol. 48 https://doi.org/10.1016/j.watres.2013.09.027	journal	January 2014
(Gold Core)@(Ceria Shell) Nanostructures for Plasmon-Enhanced Catalytic Reactions under Visible Light Li, Benxia; Gu, Ting; Ming, Tian ACS Nano, Vol. 8, Issue 8 https://doi.org/10.1021/nn502303h	journal	July 2014
Chelating Ligand-Mediated Crystal Growth of Cerium Orthovanadate Luo, Feng; Jia, Chun-Jiang; Song, Wei Crystal Growth & Design, Vol. 5, Issue 1 https://doi.org/10.1021/cg049940b	journal	January 2005
Gold nanorods and their plasmonic properties Chen, Huanjun; Shao, Lei; Li, Qian Chem. Soc. Rev., Vol. 42, Issue 7 https://doi.org/10.1039/C2CS35367A	journal	January 2013
Aqueous-Phase Synthesis of Single-Crystal Ceria Nanosheets Yu, Taekyung; Lim, Byungkwon; Xia, Younan Angewandte Chemie International Edition, Vol. 49, Issue 26 https://doi.org/10.1002/anie.201001521	journal	June 2010
Co ₃ O ₄ @CeO ₂ Core@Shell Cubes: Designed Synthesis and Optimization of Catalytic Properties Zhen, Jiangman; Wang, Xiao; Liu, Dapeng Chemistry - A European Journal, Vol. 20, Issue 15 https://doi.org/10.1002/chem.201304109	journal	February 2014
Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxide nanoparticles Singh, Sanjay; Kumar, Amit; Karakoti, Ajay Molecular BioSystems, Vol. 6, Issue 10 https://doi.org/10.1039/c0mb00014k	journal	January 2010
Role of phosphate on stability and catalase mimetic activity of cerium oxide nanoparticles Singh, Ragini; Singh, Sanjay Colloids and Surfaces B: Biointerfaces, Vol. 132 https://doi.org/10.1016/j.colsurfb.2015.05.005	journal	August 2015
Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging He, Weiwei; Zhou, Yu-Ting; Wamer, Wayne G. Biomaterials, Vol. 34, Issue 3 https://doi.org/10.1016/j.biomaterials.2012.10.010	journal	January 2013
ATP-mediated intrinsic peroxidase-like activity of Fe 3 O 4 -based nanozyme: One step detection of blood glucose at physiological pH Vallabani, N. V. Srikanth; Karakoti, Ajay S.; Singh, Sanjay Colloids and Surfaces B: Biointerfaces, Vol. 153 https://doi.org/10.1016/j.colsurfb.2017.02.004	journal	May 2017
pH-Tunable Oxidase-Like Activity of Cerium Oxide Nanoparticles Achieving Sensitive Fluorigenic Detection of Cancer Biomarkers at Neutral pH Asati, Atul; Kaittanis, Charalambos; Santra, Santimukul Analytical Chemistry, Vol. 83, Issue 7 https://doi.org/10.1021/ac102826k	journal	April 2011
An In Vitro Gastrointestinal Method To Estimate Bioavailable Arsenic in Contaminated Soils and Solid Media Rodriguez, Robin R.; Basta, Nicholas T.; Casteel, Stan W. Environmental Science & Technology, Vol. 33, Issue 4 https://doi.org/10.1021/es980631h	journal	February 1999
Bioaccessibility of Arsenic(V) Bound to Ferrihydrite Using a Simulated Gastrointestinal System Beak, Douglas G.; Basta, Nicholas T.; Scheckel, Kirk G. Environmental Science & Technology, Vol. 40, Issue 4 https://doi.org/10.1021/es0516413	journal	January 2006
Investigation of the Presence of Inorganic Micro- and Nanosized Contaminants in Bread and Biscuits by Environmental Scanning Electron Microscopy Gatti, Antonietta M.; Tossini, Daniela; Gambarelli, Andrea Critical Reviews in Food Science and Nutrition, Vol. 49, Issue 3 https://doi.org/10.1080/10408390802064347	journal	December 2008
The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery Corbo, Claudia; Molinaro, Roberto; Parodi, Alessandro Nanomedicine, Vol. 11, Issue 1 https://doi.org/10.2217/nnm.15.188	journal	January 2016
A phosphate-dependent shift in redox state of cerium oxide nanoparticles and its effects on catalytic properties Singh, Sanjay; Dosani, Talib; Karakoti, Ajay S. Biomaterials, Vol. 32, Issue 28, p. 6745-6753 https://doi.org/10.1016/j.biomaterials.2011.05.073	journal	October 2011
Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers Zhang, Wei; Hu, Sunling; Yin, Jun-Jie Journal of the American Chemical Society, Vol. 138, Issue 18 https://doi.org/10.1021/jacs.5b12070	journal	March 2016
Rates of Hydroxyl Radical Generation and Organic Compound Oxidation in Mineral-Catalyzed Fenton-like Systems Kwan, Wai P.; Voelker, Bettina M. Environmental Science & Technology, Vol. 37, Issue 6 https://doi.org/10.1021/es020874g	journal	March 2003
Investigations on the crystal plane effect of ceria on gold catalysis in the oxidative dehydrogenation of alcohols and amines in the liquid phase Wang, Min; Wang, Feng; Ma, Jiping Chem. Commun., Vol. 50, Issue 3 https://doi.org/10.1039/C3CC46180G	journal	January 2014

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