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Title: A simple thick target for production of 89 Zr using an 11 MeV cyclotron

Authors:
; ;
Publication Date:
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
OSTI Identifier:
1412942
Grant/Contract Number:
S10-RR017229
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Applied Radiation and Isotopes
Additional Journal Information:
Journal Volume: 122; Journal Issue: C; Related Information: CHORUS Timestamp: 2017-12-11 02:51:46; Journal ID: ISSN 0969-8043
Publisher:
Elsevier
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Link, Jeanne M., Krohn, Kenneth A., and O'Hara, Matthew J. A simple thick target for production of 89 Zr using an 11 MeV cyclotron. United Kingdom: N. p., 2017. Web. doi:10.1016/j.apradiso.2017.01.037.
Link, Jeanne M., Krohn, Kenneth A., & O'Hara, Matthew J. A simple thick target for production of 89 Zr using an 11 MeV cyclotron. United Kingdom. doi:10.1016/j.apradiso.2017.01.037.
Link, Jeanne M., Krohn, Kenneth A., and O'Hara, Matthew J. Sat . "A simple thick target for production of 89 Zr using an 11 MeV cyclotron". United Kingdom. doi:10.1016/j.apradiso.2017.01.037.
@article{osti_1412942,
title = {A simple thick target for production of 89 Zr using an 11 MeV cyclotron},
author = {Link, Jeanne M. and Krohn, Kenneth A. and O'Hara, Matthew J.},
abstractNote = {},
doi = {10.1016/j.apradiso.2017.01.037},
journal = {Applied Radiation and Isotopes},
number = C,
volume = 122,
place = {United Kingdom},
year = {Sat Apr 01 00:00:00 EDT 2017},
month = {Sat Apr 01 00:00:00 EDT 2017}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1016/j.apradiso.2017.01.037

Citation Metrics:
Cited by: 1work
Citation information provided by
Web of Science

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  • The growing interest but limited availability of 89Zr for PET led us to test targets for the 89(p,n) reaction. The goal was an easily constructed target for an 11 MeV Siements cyclotron. Yttrium foils were tested at different thicknesses, angles and currents. A 90 degree foil tolerated 41 microAmp without damage and produced ~800 MBq/hr, >20 mCi, an amount adequate for radiochemistry research and human doses in a widely available accelerator. This method should translate to higher energy cyclotrons.
  • Measurements of neutrons from a thick target of Hevimet were made, using beams of {sup 4}He, {sup 12}C, and {sup 16}O ions at 155 MeV per nucleon. These measurements were made both inside and outside of thick concrete shielding, using Bonner-sphere techniques. Yields, spectra, and spectral integral quantities were obtained. The neutron yields were parameterized, and a Moyer-model approach was taken to estimate the dose-equivalent outside of the thick concrete shielding. The effect of local iron shielding, and the dose equivalent outside of iron roof shielding were also investigated. Finally, two methods to obtain neutron field integral values, the {open_quotes}reconstructedmore » spectra{close_quotes} and {open_quotes}six-spheres{close_quotes} methods, were compared. The measurements and analyses should prove useful to other present or planned medium-energy heavy-ion accelerator facilities.{copyright} {ital 1999 American Institute of Physics.}« less
  • Zirconium-89 (89Zr), produced by the (p,n) reaction from naturally monoisotopic yttrium (natY), is a promising positron emitting isotope for immunoPET imaging. Its long half-life of 78.4 h is sufficient for evaluating slow physiological processes. A prototype automated fluidic system, coupled to on-line and in-line detectors, has been constructed to facilitate development of new 89Zr purification methodologies. The highly reproducible reagent delivery platform and near-real time monitoring of column effluents allows for efficient method optimization. The separation of Zr from dissolved Y metal targets was evaluated using several anion exchange resins. Each resin was evaluated against its ability to quantitatively capturemore » Zr from a load solution that is high in dissolved Y. The most appropriate anion exchange resin for this application was identified, and the separation method was optimized. The method is capable of a high Y decontamination factor (>105) and has been shown to separate Fe, an abundant contaminant in Y foils, from the 89Zr elution fraction. Finally, the performance of the method was evaluated using cyclotron bombarded Y foil targets. The separation method was shown to achieve >95% recovery of the 89Zr present in the foils. The 89Zr eluent, however, was in a chemical matrix not immediately conducive to labeling onto proteins. The main intent of this study was to develop a tandem column 89Zr purification process, wherein the anion exchange column method described here is the first separation in a dual-column purification process.« less
  • Zirconium-89 ( 89Zr), produced by the (p, n) reaction from naturally monoisotopic yttrium ( natY), is a promising positron emitting isotope for immunoPET imaging. Its long half-life of 78.4 h is sufficient for evaluating slow physiological processes. A prototype automated fluidic system, coupled to on-line and in-line detectors, has been constructed to facilitate development of new 89Zr purification methodologies. The highly reproducible reagent delivery platform and near-real time monitoring of column effluents allows for efficient method optimization. The separation of Zr from dissolved Y metal targets was evaluated using several anion exchange resins. Each resin was evaluated against its abilitymore » to quantitatively capture Zr from a load solution high in dissolved Y. The most appropriate anion exchange resin for this application was identified, and the separation method was optimized. The method is capable of a high Y decontamination factor (>10 5) and has been shown to remove Fe, an abundant contaminant in Y foils, from the 89Zr elution fraction. Finally, the method was evaluated using cyclotron bombarded Y foil targets; the method was shown to achieve >95% recovery of the 89Zr present in the foils. The anion exchange column method described here is intended to be the first 89Zr isolation stage in a dual-column purification process.« less