skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices

Authors:
; ; ; ORCiD logo; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1412601
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Regulatory Toxicology and Pharmacology
Additional Journal Information:
Journal Volume: 85; Journal Issue: C; Related Information: CHORUS Timestamp: 2017-12-11 06:52:15; Journal ID: ISSN 0273-2300
Publisher:
Elsevier
Country of Publication:
United States
Language:
English

Citation Formats

Savery, Laura C., Viñas, René, Nagy, Amber M., Pradeep, Prachi, Merrill, Stephen J., Hood, Alan M., Malghan, Subhas G., Goering, Peter L., and Brown, Ronald P. Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices. United States: N. p., 2017. Web. doi:10.1016/j.yrtph.2017.01.007.
Savery, Laura C., Viñas, René, Nagy, Amber M., Pradeep, Prachi, Merrill, Stephen J., Hood, Alan M., Malghan, Subhas G., Goering, Peter L., & Brown, Ronald P. Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices. United States. doi:10.1016/j.yrtph.2017.01.007.
Savery, Laura C., Viñas, René, Nagy, Amber M., Pradeep, Prachi, Merrill, Stephen J., Hood, Alan M., Malghan, Subhas G., Goering, Peter L., and Brown, Ronald P. Sat . "Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices". United States. doi:10.1016/j.yrtph.2017.01.007.
@article{osti_1412601,
title = {Deriving a provisional tolerable intake for intravenous exposure to silver nanoparticles released from medical devices},
author = {Savery, Laura C. and Viñas, René and Nagy, Amber M. and Pradeep, Prachi and Merrill, Stephen J. and Hood, Alan M. and Malghan, Subhas G. and Goering, Peter L. and Brown, Ronald P.},
abstractNote = {},
doi = {10.1016/j.yrtph.2017.01.007},
journal = {Regulatory Toxicology and Pharmacology},
number = C,
volume = 85,
place = {United States},
year = {Sat Apr 01 00:00:00 EDT 2017},
month = {Sat Apr 01 00:00:00 EDT 2017}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1016/j.yrtph.2017.01.007

Citation Metrics:
Cited by: 1work
Citation information provided by
Web of Science

Save / Share:
  • Cited by 13
  • The effects of intravenous injection of an ionic contrast material (Renografin-76 (meglumine sodium diatrizoate)) on left ventricular pressure, internal diameter, and wall thickness, and on coronary and femoral hemodynamics were compared with those of a hydrolytically stable nonionic contrast material (iohexol). Renografin-76 caused drastic biphasic changes in left ventricular pressure and dp/dt (rate of change of left ventricular pressure), and moderate changes in end systolic dimension. Iohexol caused little or no change in left ventricular pressure and dimensions. In addition, Renografin-76 caused marked arterial hypotension and large increases in coronary and femoral blood lows, while iohexol caused no significant changemore » in arterial pressure and coronary blood flow, and a mild increase in femoral blood flow. Based on these findings, it is concluded that iohexol is preferable to standard ionic contrast material for deriving basal physiologic information from computed tomographic and digital vascular studies.« less
  • Exposure duration is an important component in determining long-term dose rates associated with exposure to environmental contaminants. Surveys of exposed populations collect information on individuals` past behaviors, including the durations of a behavior up to the time of the survey. This paper presents an empirical approach for determining the distribution of total durations that is consistent with the distribution past durations obtained from surveys. This approach is appropriate where the rates of beginning and ending a behavior are relatively constant over time. The approach allows the incorporation of information on the distribution of age in a population into the determinationmore » of the distribution of durations. The paper also explores the impact of longevity bias on survey data. A case study of the application of this approach to two angler populations is also provided. The results of the case study have characteristics similar to the results reported by Israeli and Nelson from their analytical model of residential duration. Specifically, the average period of time for the total duration in the entire population is shorter than the average period of time reported for historical duration in the surveyed individuals.« less
  • Journal article on the role that radioxenon isotopes play in confirming whether or not an underground explosion was nuclear in nature. Radioxenon isotopes play a major role in confirming whether or not an underground explosion was nuclear in nature. It is then of key importance to understand the sources of environmental radioxenon to be able to distinguish civil sources from those of a nuclear explosion. Based on several years of measurements, combined with advanced atmospheric transport model results, it was recently shown that the main source of radioxenon observations are strong and regular batch releases from a very limited numbermore » of medical isotope production facilities. This paper reviews production processes in different medical isotope facilities during which radioxenon is produced. Radioxenon activity concentrations and isotopic compositions are calculated for six large facilities. The results are compared with calculated signals from nuclear explosions. Further, the outcome is compared and found to be consistent with radioxenon measurements recently performed in and around three of these facilities. Some anomalies in measurements in which {sup 131m}Xe was detected were found and a possible explanation is proposed. It was also calculated that the dose rate of the releases is well below regulatory values. Based on these results, it should be possible to better understand, interpret and verify signals measured in the noble gas measurement systems in the International Monitoring of the Comprehensive Nuclear-Test-Ban Treaty.« less
  • Abstract The International Monitoring System (IMS) of the Comprehensive-Nuclear-Test-Ban-Treaty monitors the atmosphere for radioactive xenon leaking from underground nuclear explosions. Emissions from medical isotope production represent a challenging background signal when determining whether measured radioxenon in the atmosphere is associated with a nuclear explosion prohibited by the treaty. The Australian Nuclear Science and Technology Organisation (ANSTO) operates a reactor and medical isotope production facility in Lucas Heights, Australia. This study uses two years of release data from the ANSTO medical isotope production facility and Xe-133 data from three IMS sampling locations to estimate the annual releases of Xe-133 from medicalmore » isotope production facilities in Argentina, South Africa, and Indonesia. Atmospheric dilution factors derived from a global atmospheric transport model were used in an optimization scheme to estimate annual release values by facility. The annual releases of about 6.8×1014 Bq from the ANSTO medical isotope production facility are in good agreement with the sampled concentrations at these three IMS sampling locations. Annual release estimates for the facility in South Africa vary from 1.2×1016 to 2.5×1016 Bq and estimates for the facility in Indonesia vary from 6.1×1013 to 3.6×1014 Bq. Although some releases from the facility in Argentina may reach these IMS sampling locations, the solution to the objective function is insensitive to the magnitude of those releases.« less