Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells

Brandt, Benjamin; Munemasa, Shintaro; Wang, Cun; Nguyen, Desiree; Yong, Taiming; Yang, Paul G.; Poretsky, Elly; Belknap, Thomas F.; Waadt, Rainer; Alemán, Fernando; Schroeder, Julian I.

doi:10.7554/eLife.03599

Title: Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells

Journal Article · Mon Jul 20 00:00:00 EDT 2015 · eLife

DOI:https://doi.org/10.7554/eLife.03599· OSTI ID:1196443

Brandt, Benjamin ^[1]; Munemasa, Shintaro ^[1]; Wang, Cun ^[1]; Nguyen, Desiree ^[1]; Yong, Taiming ^[1]; Yang, Paul G. ^[1]; Poretsky, Elly ^[1]; Belknap, Thomas F. ^[1]; Waadt, Rainer ^[1]; Alemán, Fernando ^[1]; Schroeder, Julian I. ^[1]

Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, San Diego, United States

One central question is how specificity in cellular responses to the eukaryotic second messenger Ca²⁺ is achieved. Plant guard cells, that form stomatal pores for gas exchange, provide a powerful system for in depth investigation of Ca²⁺-signaling specificity in plants. In intact guard cells, abscisic acid (ABA) enhances (primes) the Ca²⁺-sensitivity of downstream signaling events that result in activation of S-type anion channels during stomatal closure, providing a specificity mechanism in Ca²⁺-signaling. However, the underlying genetic and biochemical mechanisms remain unknown. Here we show impairment of ABA signal transduction in stomata of calcium-dependent protein kinase quadruple mutant plants. Interestingly, protein phosphatase 2Cs prevent non-specific Ca²⁺-signaling. Moreover, we demonstrate an unexpected interdependence of the Ca²⁺-dependent and Ca²⁺-independent ABA-signaling branches and the in planta requirement of simultaneous phosphorylation at two key phosphorylation sites in SLAC1. We identify novel mechanisms ensuring specificity and robustness within stomatal Ca²⁺-signaling on a cellular, genetic, and biochemical level.

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Research Organization:: Univ. of California, San Diego, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH); National Science Foundation (NSF)

Grant/Contract Number:: FG02-03ER15449; GM060396-ES010337; MCB1414339

OSTI ID:: 1196443

Alternate ID(s):: OSTI ID: 1198705; OSTI ID: 1411725

Journal Information:: eLife, Journal Name: eLife Vol. 4; ISSN 2050-084X

Publisher:: eLife Sciences Publications, Ltd.Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 170 works

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