skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

Abstract

Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. Here in this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.

Authors:
 [1];  [1];  [2]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  2. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Univ. of California, Merced, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1411555
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Journal Article
Journal Name:
Cell
Additional Journal Information:
Journal Volume: 167; Journal Issue: 5; Journal ID: ISSN 0092-8674
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Spurrell, Cailyn H., Dickel, Diane E., and Visel, Axel. The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome. United States: N. p., 2016. Web. doi:10.1016/j.cell.2016.10.054.
Spurrell, Cailyn H., Dickel, Diane E., & Visel, Axel. The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome. United States. doi:10.1016/j.cell.2016.10.054.
Spurrell, Cailyn H., Dickel, Diane E., and Visel, Axel. Thu . "The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome". United States. doi:10.1016/j.cell.2016.10.054. https://www.osti.gov/servlets/purl/1411555.
@article{osti_1411555,
title = {The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome},
author = {Spurrell, Cailyn H. and Dickel, Diane E. and Visel, Axel},
abstractNote = {Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. Here in this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.},
doi = {10.1016/j.cell.2016.10.054},
journal = {Cell},
issn = {0092-8674},
number = 5,
volume = 167,
place = {United States},
year = {2016},
month = {11}
}

Works referencing / citing this record:

The hyper-activation of transcriptional enhancers in breast cancer
journal, March 2019