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Title: Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them

Abstract

Recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making recombinant cells and recombinant organisms dependent on persistently expressing NSAAs for survival are also provided. These methods may be used to make safe recombinant cells and recombinant organisms and/or to provide a selective pressure to maintain one or more reassigned codon functions in recombinant cells and recombinant organisms.

Inventors:
; ;
Publication Date:
Research Org.:
President and Fellows of Harvard College, Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1411431
Patent Number(s):
9,834,775
Application Number:
15/025,406
Assignee:
President and Fellows of Harvard College (Cambridge, MA) CHO
DOE Contract Number:
FG02-02ER63445
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Sep 26
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Church, George M., Mandell, Daniel J., and Lajoie, Marc J.. Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them. United States: N. p., 2017. Web.
Church, George M., Mandell, Daniel J., & Lajoie, Marc J.. Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them. United States.
Church, George M., Mandell, Daniel J., and Lajoie, Marc J.. Tue . "Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them". United States. doi:. https://www.osti.gov/servlets/purl/1411431.
@article{osti_1411431,
title = {Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them},
author = {Church, George M. and Mandell, Daniel J. and Lajoie, Marc J.},
abstractNote = {Recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making recombinant cells and recombinant organisms dependent on persistently expressing NSAAs for survival are also provided. These methods may be used to make safe recombinant cells and recombinant organisms and/or to provide a selective pressure to maintain one or more reassigned codon functions in recombinant cells and recombinant organisms.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 05 00:00:00 EST 2017},
month = {Tue Dec 05 00:00:00 EST 2017}
}

Patent:

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