Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them
Patent
·
OSTI ID:1411431
Recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making recombinant cells and recombinant organisms dependent on persistently expressing NSAAs for survival are also provided. These methods may be used to make safe recombinant cells and recombinant organisms and/or to provide a selective pressure to maintain one or more reassigned codon functions in recombinant cells and recombinant organisms.
- Research Organization:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-02ER63445
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- Patent Number(s):
- 9,834,775
- Application Number:
- 15/025,406
- OSTI ID:
- 1411431
- Resource Relation:
- Patent File Date: 2014 Sep 26
- Country of Publication:
- United States
- Language:
- English
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