skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins

Patent ·
OSTI ID:1410329

The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response to HIV-1 in a human.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-06NA25396
Assignee:
Duke University (Durham, NC); Los Alamos National Security, LLC (Los Alamos, NM); The UAB Research Foundation (Birmingham, AL); Beth Israel Deaconess Medical Center (Boston, MA)
Patent Number(s):
9,821,053
Application Number:
14/689,995
OSTI ID:
1410329
Resource Relation:
Patent File Date: 2015 Apr 17
Country of Publication:
United States
Language:
English

References (72)

Delivery of exogenous DNA sequences in a mammal patent December 1996
Induction of a protective immune response in a mammal by injecting a DNA sequence patent December 1996
Generation of antibodies through lipid mediated DNA delivery patent December 1997
Stabilized viral envelope proteins and uses thereof patent March 2004
Ancestral and COT viral sequences, proteins and immunogenic compositions patent February 2010
Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins patent February 2012
Human immunodeficiency virus type 1 clade M mosaic gag polypeptides patent April 2015
Antigen Library Immunization patent-application December 2002
Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications patent-application March 2003
Method for the development of an HIV vaccine patent-application June 2003
Polyvalent immunogen patent-application August 2003
Immunogenic, cross-clade, HIV peptides patent-application September 2003
Peptide compositions for the treatment and prevention of HIV infection patent-application October 2003
Polyvalent immunogen patent-application January 2004
Ancestral and COT viral sequences, proteins and immunogenic compositions patent-application June 2005
Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use patent-application September 2006
HIV vaccines based on Env of multiple clades of HIV patent-application December 2006
Consensus/ancestral immunogens patent-application August 2007
Polyvalent Vaccine patent-application December 2009
Polyvalent Vaccine patent-application June 2011
Polyvalent Vaccine patent-application May 2012
Identification of Highly Conserved and Broadly Cross-Reactive HIV Type 1 Cytotoxic T Lymphocyte Epitopes as Candidate Immunogens for Inclusion in Mycobacterium bovis BCG-Vectored HIV Vaccines journal September 2000
De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection journal September 2005
HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus journal November 2002
A New Variant Cytotoxic T Lymphocyte Escape Mutation in HLA-B27-Positive Individuals Infected with HIV Type 1 journal May 2005
Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination journal October 2000
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys journal February 2010
Viral Escape from Dominant Simian Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes in DNA-Vaccinated Rhesus Monkeys journal July 2003
Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition journal March 2005
HIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway journal December 2002
Prospects for an AIDS vaccine journal March 2004
Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope journal August 2005
HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response journal June 2005
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants journal December 2006
Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple Ethnicities journal February 2004
The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years journal September 2005
Diversity Considerations in HIV-1 Vaccine Selection journal June 2002
Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins journal September 2009
Codon usage limitation in the expression of HIV-1 envelope glycoprotein journal March 1996
DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice journal February 1998
Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates journal January 2014
Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes journal December 2005
Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response journal November 2004
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA journal December 2004
Clonal breadth of the HIV-1-specific T-cell receptor repertoire in vivo as determined by subtractive analysis journal January 2005
Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination journal December 2008
Immunogenicity of Multiple Gene and Clade Human Immunodeficiency Virus Type 1 DNA Vaccines journal November 2003
Evolutionary and immunological implications of contemporary HIV-1 variation journal September 2001
T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces journal May 2009
T Cell Cross-Reactivity and Conformational Changes during TCR Engagement journal December 2004
A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses journal September 2006
HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity journal January 2004
HIV VACCINES journal December 2005
CD8+ T Cell Epitope-Flanking Mutations Disrupt Proteasomal Processing of HIV-1 Nef journal September 2005
Urgently needed: a filter for the HIV-1 vaccine pipeline journal August 2004
HIV vaccine strategies journal February 2002
Fine Specificity and Cross-Clade Reactivity of HIV Type 1 Gag-Specific CD4+ T Cells journal March 2004
HIV‐Specific Cellular Immune Response Is Inversely Correlated with Disease Progression as Defined by Decline of CD4+ T Cells in Relation to HIV RNA Load
  • Oxenius, Annette; Price, David A.; Hersberger, Martin
  • The Journal of Infectious Diseases, Vol. 189, Issue 7, p. 1199-1208 https://doi.org/10.1086/382028
journal April 2004
Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity journal January 2006
Recombination in HIV-1 journal March 1995
A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys journal July 2008
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys journal February 2010
Use of T Cell Epitopes for Vaccine Development journal November 2001
Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes journal February 1999
Multiclade Human Immunodeficiency Virus Type 1 Envelope Immunogens Elicit Broad Cellular and Humoral Immunity in Rhesus Monkeys journal February 2005
Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice journal September 2004
The Role of T Cell Antagonism and Original Antigenic Sin in Genetic Immunization journal December 2002
Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia journal October 2008
Toward an AIDS Vaccine journal May 2008
Cross-Subtype T-Cell Immune Responses Induced by a Human Immunodeficiency Virus Type 1 Group M Consensus Env Immunogen journal June 2006
Characterization and Selection of HIV-1 Subtype C Isolates for Use in Vaccine Development journal February 2003
Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation journal September 2002